Literature summary for 2.4.2.10 extracted from

Sanada, Y.; Yoshida, K.; Hihara, J.; Okada, M.
Expression of orotate phosphoribosyltransferase in colorectal carcinoma: an immunohistochemical analysis in several components of neoplastic lesions (2008), Oncol. Rep., 20, 1005-1011.

Search for more literature for 2.4.2.10

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	in metastatic lymph nodes and lymphovascularly invasive lesions	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	in normal non-neoplastic colorectal epithelium, granular staining is observed only in the crypt	Homo sapiens	-
additional information	in mucosal carcinoma lesions frequency of OPRT expression is 32.1%, in infiltrative lesions frequency of OPRT expression is 69.8%. In lymphovascularly invasive lesions frequency of OPRT expression is 88.2% and in metastatic lymph nodes frequency of OPRT expression is 88.8%	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
OPRT	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	non-cancerous components do not express OPRT	down
Homo sapiens	lexpression of OPRT in mucosal carcinoma components, in infiltrative components, in lymphovascularly invasive lesions and in metastatic lymph nodes. No significant correlation between OPRT expression and cancer stage, T-grade or N-grade, but OPRT expression correlates positively with the presence of lymphovascular invasion. OPRT is diffusely expressed to a greater extent, especially in the tumor cells adjacent to the infiltrative margin	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)