Reference on EC 2.1.1.45 - thymidylate synthase and Organism(s) Homo sapiens and UniProt Accession P04818
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Blakeley, R.L.
The biosythesis of thymidylic acid. IV. Further studies on thymidylate synthetase
J. Biol. Chem.
238
2113-2118
1963
Escherichia coli, Enterococcus faecalis, Homo sapiens
-
Fridland, A.; Langenbach, R.J.; Heidelberger, C.
Purification of thymidylate synthetase from Ehrlich ascites carcinoma cells
J. Biol. Chem.
246
7110-7114
1971
Bos taurus, Gallus gallus, Escherichia coli, Enterococcus faecalis, Homo sapiens, Lacticaseibacillus casei, Mus musculus
Loeble, R.B.; Dunlap, R.B.
Characterization of the subunits of thymidylate synthetase
Biochem. Biophys. Res. Commun.
49
1671-1677
1972
Homo sapiens, Lacticaseibacillus casei
Danenberg, P.V.
Thymidylate synthetase - a target enzyme in cancer chemotherapy
Biochim. Biophys. Acta
473
73-92
1977
Enterococcus faecalis, Escherichia coli, Escherichia coli B / ATCC 11303, Homo sapiens, Lacticaseibacillus casei, Mus musculus, Streptococcus pneumoniae
Dolnick, B.J.; Cheng, Y.C.
Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors
J. Biol. Chem.
253
3563-3567
1978
Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia coli R2, Homo sapiens, Lacticaseibacillus casei
Lockshin, A.; Moran, R.G.; Danenberg, P.V.
Thymidylate synthetase purified to homogeneity from human leukemic cells
Proc. Natl. Acad. Sci. USA
76
750-754
1979
Escherichia phage T2, Bos taurus, Escherichia coli, Homo sapiens, Lacticaseibacillus casei
Rode, W.; Scanlon, K.J.; Hynes, J.; Bertino, J.R.
Purification of mammalian tumor (L1210) thymidylate synthetase by affinity chromatography on stable biospecific adsorbent. Stabilization of the enzyme with neutral detergents
J. Biol. Chem.
254
11538-11543
1979
Escherichia coli, Homo sapiens, Lacticaseibacillus casei, Mus musculus
Bisson, L.F.; Thorner, J.
Thymidylate synthetase from Saccharomyces cerevisiae. Purification and enzymic properties
J. Biol. Chem.
256
12456-12462
1981
Saccharomyces cerevisiae, Gallus gallus, Enterococcus faecalis, Homo sapiens, Lacticaseibacillus casei, Mus musculus
Banerjee, C.K.; Bennett, L.L.; Brockman, R.W.; Sani, B.P.; Temple, C.
A convenient procedure for purification of thymidylate synthase from L1210 cells
Anal. Biochem.
121
275-280
1982
Gallus gallus, Homo sapiens, Lacticaseibacillus casei, Mus musculus
Pattanakitsakul, S.N.; Ruenwongsa, P.
Characterization of thymidylate synthetase and dihydrofolate reductase from Plasmodium berghei
Int. J. Parasitol.
14
513-520
1984
Crithidia fasciculata, Streptococcus pneumoniae, Escherichia coli, Homo sapiens, Lacticaseibacillus casei, Leishmania major, Plasmodium berghei
Nakata, R.; Tsukamoto, I.; Miyoshi, M.; Kojo, S.
Purification and characterization of thymidylate synthetase from rat regenerating liver
Biochim. Biophys. Acta
924
297-302
1987
Homo sapiens, Lacticaseibacillus casei, Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar, Saccharomyces cerevisiae
Radparvar, S.; Houghton, P.J.; Houghton, J.A.
Characteristics of thymidylate synthase purified from a human colon adenocarcinoma
Arch. Biochem. Biophys.
260
342-350
1988
Homo sapiens, Sus scrofa
Balinska, M.; Rhee, M.; Whiteley, J.M.; Priest, D.G.; Galivan, J.
Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate
Arch. Biochem. Biophys.
284
219-222
1991
Homo sapiens, Mus musculus, Rattus norvegicus
Zhang, H.; Cisneros, R.J.; Deng, W.; Zapf, J.W.; Johnson, L.F.; Dunlap, R.B.
Purification and characterization of recombinant mouse thymidylate synthase
Biochim. Biophys. Acta
1077
35-46
1991
Homo sapiens, Lacticaseibacillus casei, Mus musculus
Livi, L.L.; Edman, U.; Schneider, G.P.; Greene, P.J.; Santi, D.V.
Cloning, expression and characterization of thymidylate synthase from Cryptococcus neoformans
Gene
150
221-226
1994
Tequatrovirus T4, Candida albicans, Homo sapiens, Lacticaseibacillus casei, Mus musculus, Pneumocystis carinii, Cryptococcus neoformans (P0CS13), Cryptococcus neoformans, Cryptococcus neoformans B-3501A (P0CS13)
So, N.N.C.; Wong, P.C.L.; Ko, R.C.
Angiostrongylus cantonensis: Characterization of thymidylate synthetase
Exp. Parasitol.
79
526-535
1994
Aedes aegypti, Angiostrongylus cantonensis, Bos taurus, Saccharomyces cerevisiae, Brugia pahangi, Candida albicans, Gallus gallus, Crithidia fasciculata, Homo sapiens, Leishmania major, Mus musculus, Plasmodium falciparum, Rattus norvegicus, Sus scrofa, Toxoplasma gondii
Schiffer, C.A.; Clifton, I.J.; Davisson, V.J.; Santi, D.V.; Stroud, R.M.
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site
Biochemistry
34
16279-16287
1995
Homo sapiens
Voeller, D.M.; Changchien, L.M.; Maley, G.F.; Maley, F.; Takechi, T.; Turner, R.E.; Montfort, W.R.; Allegra, C.J.; Chu, E.
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA
Nucleic Acids Res.
23
869-875
1995
Tequatrovirus T4, Escherichia coli, Enterococcus faecium, Homo sapiens
Hekmat-Nejad, M.; Rathod, P.K.
Kinetics of Plasmodium flaciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694
Antimicrob. Agents Chemother.
40
1628-1632
1996
Crithidia fasciculata, Escherichia coli, Homo sapiens, Leishmania major, Mus musculus, Plasmodium berghei, Plasmodium falciparum, Plasmodium yoelii
Spencer, H.T.; Villafranca, J.E.; Appleman, J.R.
Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis
Biochemistry
36
4212-4222
1997
Tequatrovirus T4, Candida albicans, Escherichia coli, Homo sapiens, Lacticaseibacillus casei, Mus musculus
Tong, Y.; Liu-Chen, X.; Ercikan-Abali, E.A.; Capiaux, G.M.; Zhao, S.C.; Banerjee, D.; Bertino, J.R.
Isolation and characterization of Thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells
J. Biol. Chem.
273
11611-11618
1998
Escherichia coli, Homo sapiens, Lacticaseibacillus casei, Cryptococcus neoformans (P0CS13), Cryptococcus neoformans B-3501A (P0CS13)
Mahdavian, E.; Spencer, H.T.; Dunlap, R.B.
Kinetic studies on drug-resistant variants of Escherichia coli thymidylate sythase: Functional effects of amino acid sunstitutions at residue 4
Arch. Biochem. Biophys.
368
257-264
1999
Escherichia coli, Homo sapiens
Steadman, D.J.; Spencer, H.T.; Dunlap, R.B.; Berger, S.H.
Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes
Biochemistry
38
5582-5587
1999
Escherichia coli, Homo sapiens, Lacticaseibacillus casei
Fantz, C.; Shaw, D.; Jennings, W.; Forsthoefel, A.; Kitchens, M.; Phan, J.; Minor, W.; Lebioda, L.; Berger, F.G.; Spencer, H.T.
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254
Mol. Pharmacol.
57
359-366
2000
Homo sapiens, Mus musculus, Escherichia coli (P0A884), Escherichia coli
Jarmula, A.; Les, A.; Rode, W.
Different activities of 5-hydroxy-dUMP and 5-hydroxymethyl-dUMP in thymidylate synthase-catalyzed reaction in view of molecular modeling and structural studies
Bioorg. Chem.
28
156-162
2000
Homo sapiens
Phan, J.; Mahdavian, E.; Nivens, M.C.; Minor, W.; Berger, S.; Spencer, H.T.; Dunlap, R.B.; Lebioda, L.
Catalytic cysteine of thymidylate synthase is activated upon substrate binding
Biochemistry
39
6969-6978
2000
Homo sapiens, Lacticaseibacillus casei, Escherichia coli (P0A884), Escherichia coli
Golos, B.; Dzik, J.M.; Kazimierczuk, Z.; Ciesla, J.; Zielinski, Z.; Jankowska, J.; Kraszewski, A.; Stawinski, J.; Rode, W.; Shugar, D.
Interaction of thymidylate synthase with the 5'-thiophosphates, 5'-dithiophosphates, 5'-H-phosphonates and 5'-S-thiosulfates of 2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine
Biol. Chem.
382
1439-1445
2001
Escherichia coli, Homo sapiens, Lacticaseibacillus casei, Mus musculus, Pneumocystis carinii, Rattus norvegicus, Trichinella pseudospiralis, Trichinella spiralis
Kawate, H.; Landis, D.M.; Loeb, L.A.
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine
J. Biol. Chem.
277
36304-36311
2002
Homo sapiens (P04818), Homo sapiens
Gangjee, A.; Li, W.; Yang, J.; Kisliuk, R.L.
Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
J. Med. Chem.
51
68-76
2008
Escherichia coli, Homo sapiens, Toxoplasma gondii
Lovelace, L.L.; Gibson, L.M.; Lebioda, L.
Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors
Biochemistry
46
2823-2830
2007
Homo sapiens, Homo sapiens (P04818)
Gibson, L.M.; Lovelace, L.L.; Lebioda, L.
The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195
Biochemistry
47
4636-4643
2008
Homo sapiens (P04818), Homo sapiens
Giovannetti, E.; Backus, H.H.; Wouters, D.; Ferreira, C.G.; van Houten, V.M.; Brakenhoff, R.H.; Poupon, M.F.; Azzarello, A.; Pinedo, H.M.; Peters, G.J.
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels
Br. J. Cancer
96
769-775
2007
Homo sapiens
Clamp, A.R.; Schoeffski, P.; Valle, J.W.; Wilson, R.H.; Marreaud, S.; Govaerts, A.S.; Debois, M.; Lacombe, D.; Twelves, C.; Chick, J.; Jayson, G.C.; Jayson, G.C.
A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer
Cancer Chemother. Pharmacol.
61
579-585
2008
Homo sapiens
Pillai, R.G.; Forster, M.; Perumal, M.; Mitchell, F.; Leyton, J.; Aibgirhio, F.I.; Golovko, O.; Jackman, A.L.; Aboagye, E.O.
Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945
Cancer Res.
68
3827-3834
2008
Homo sapiens
Luo, Y.; Walla, M.; Wyatt, M.D.
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase
DNA Repair
7
162-169
2008
Homo sapiens
Waldman, B.C.; Wang, Y.; Kilaru, K.; Yang, Z.; Bhasin, A.; Wyatt, M.D.; Waldman, A.S.
Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase
DNA Repair
7
1624-1635
2008
Homo sapiens
Nief, N.; Le Morvan, V.; Robert, J.
Involvement of gene polymorphisms of thymidylate synthase in gene expression, protein activity and anticancer drug cytotoxicity using the NCI-60 panel
Eur. J. Cancer
43
955-962
2007
Homo sapiens
Jason, T.L.; Berg, R.W.; Vincent, M.D.; Koropatnick, J.
Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs
Gene Expr.
13
227-239
2007
Homo sapiens
Curtin, K.; Ulrich, C.M.; Samowitz, W.S.; Bigler, J.; Caan, B.; Potter, J.D.; Slattery, M.L.
Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival
Int. J. Cancer
120
2226-2232
2007
Homo sapiens
Gangjee, A.; Qiu, Y.; Li, W.; Kisliuk, R.L.
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates
J. Med. Chem.
51
5789-5797
2008
Escherichia coli, Toxoplasma gondii, Homo sapiens (P04818), Homo sapiens
Okabe, T.; Okamoto, I.; Tsukioka, S.; Uchida, J.; Iwasa, T.; Yoshida, T.; Hatashita, E.; Yamada, Y.; Satoh, T.; Tamura, K.; Fukuoka, M.; Nakagawa, K.
Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase
Mol. Cancer Ther.
7
599-606
2008
Homo sapiens
Codacci-Pisanelli, G.; Noordhuis, P.; van der Wilt, C.L.; Peters, G.J.
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin
Nucleosides Nucleotides Nucleic Acids
27
733-739
2008
Homo sapiens, Mus musculus
Giovannetti, E.; Backus, H.H.; Wouters, D.; Peters, G.J.
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells
Nucleosides Nucleotides Nucleic Acids
27
740-745
2008
Homo sapiens
Yan, S.; Niu, R.; Wang, Z.; Lin, X.
In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation
Sci. China C Life Sci.
50
630-636
2007
Homo sapiens
Giudice, S.; Benassi, L.; Bertazzoni, G.; Costi, M.P.; Gelain, A.; Venturelli, A.; Bernardi, C.; Gualdi, G.; Coppi, A.; Rossi, T.; Giannetti, A.; Magnoni, C.
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines
Toxicol. in Vitro
21
240-248
2007
Homo sapiens
McGuire, J.J.; Haile, W.H.
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4-methyleneglutamic acid (CH-1504) and its analogs
Biochem. Pharmacol.
77
1161-1172
2009
Homo sapiens
Showalter, S.L.; Showalter, T.N.; Witkiewicz, A.; Havens, R.; Kennedy, E.P.; Hucl, T.; Kern, S.E.; Yeo, C.J.; Brody, J.R.
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?
Cancer Biol. Ther.
7
986-994
2008
Homo sapiens
Monica, V.; Scagliotti, G.V.; Ceppi, P.; Righi, L.; Cambieri, A.; Lo Iacono, M.; Saviozzi, S.; Volante, M.; Novello, S.; Papotti, M.
Differential thymidylate synthase expression in different variants of large-cell carcinoma of the lung
Clin. Cancer Res.
15
7547-7552
2009
Homo sapiens
Jason, T.L.; Figueredo, R.; Ferguson, P.J.; Vincent, M.D.; Berg, R.W.; Koropatnick, J.
ODN 491, a novel antisense oligodeoxynucleotide that targets thymidylate synthase, exerts cell-specific effects in human tumor cell lines
DNA Cell Biol.
27
229-240
2008
Homo sapiens
Bielas, J.H.; Schmitt, M.W.; Icreverzi, A.; Ericson, N.G.; Loeb, L.A.
Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells
Hum. Gene Ther.
20
1703-1707
2009
Homo sapiens
Gangjee, A.; Li, W.; Kisliuk, R.L.; Cody, V.; Pace, J.; Piraino, J.; Makin, J.
Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents
J. Med. Chem.
52
4892-4902
2009
Escherichia coli, Homo sapiens, Toxoplasma gondii
Leclerc, G.J.; Mou, C.; Leclerc, G.M.; Mian, A.M.; Barredo, J.C.
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy
Leukemia
24
552-562
2010
Homo sapiens
Lovelace, L.L.; Johnson, S.R.; Gibson, L.M.; Bell, B.J.; Berger, S.H.; Lebioda, L.
Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation
Protein Sci.
18
1628-1636
2009
Homo sapiens (P04818), Homo sapiens
Gangjee, A.; Jain, H.D.; Phan, J.; Guo, X.; Queener, S.F.; Kisliuk, R.L.
2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors
Bioorg. Med. Chem.
18
953-961
2010
Escherichia coli, Homo sapiens, Toxoplasma gondii
Huang, X.; Gibson, L.M.; Bell, B.J.; Lovelace, L.L.; Pena, M.M.; Berger, F.G.; Berger, S.H.; Lebioda, L.
Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
Biochemistry
49
2475-2482
2010
Homo sapiens
Jarmula, A.; Fraczyk, T.; Cieplak, P.; Rode, W.
Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase
Bioorg. Med. Chem.
18
3361-3370
2010
Homo sapiens
Wang, Z.; Kohen, A.
Thymidylate synthase catalyzed H-transfers: two chapters in one tale
J. Am. Chem. Soc.
132
9820-9825
2010
Homo sapiens
Cardinale, D.; Salo-Ahen, O.; Guaitoli, G.; Ferrari, S.; Venturelli, A.; Franchini, S.; Battini, R.; Ponterini, G.; Wade, R.; Costi, M.
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding
Protein Eng.
23
81-89
2010
Homo sapiens
Luo, B.; Repalli, J.; Yousef, A.M.; Johnson, S.R.; Lebioda, L.; Berger, S.H.
Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles
Protein Sci.
20
87-94
2011
Homo sapiens
Cannazza, G.; Cazzato, A.S.; Marraccini, C.; Pavesi, G.; Pirondi, S.; Guerrini, R.; Pela, M.; Frassineti, C.; Ferrari, S.; Marverti, G.; Ponterini, G.; Costi, M.P.
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells
J. Med. Chem.
57
10551-10556
2014
Homo sapiens
Wang, N.; McCammon, J.A.
Substrate channeling between the human dihydrofolate reductase and thymidylate synthase
Protein Sci.
25
79-86
2016
Homo sapiens (P04818), Homo sapiens
Deschamps, P.; Rety, S.; Bareille, J.; Leulliot, N.
Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates
Acta Crystallogr. Sect. F
73
336-341
2017
Homo sapiens (P04818), Homo sapiens
Amin, L.H.T.; Shawer, T.Z.; El-Naggar, A.M.; El-Sehrawi, H.M.A.
Design, synthesis, anticancer evaluation and docking studies of new pyrimidine derivatives as potent thymidylate synthase inhibitors
Bioorg. Chem.
91
103159
2019
Homo sapiens (P04818)
Li, X.Y.; Liang, J.W.; Mohamed O, K.; Zhang, T.J.; Lu, G.Q.; Meng, F.H.
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs
Eur. J. Med. Chem.
154
267-279
2018
Homo sapiens (P04818)
Lu, G.Q.; Li, X.Y.; Mohamed O, K.; Wang, D.; Meng, F.H.
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs
Eur. J. Med. Chem.
171
282-296
2019
Homo sapiens (P04818)
Heble, N.; Mavillapalli, R.; Selvaraj, R.; Jeyabalan, S.
Molecular docking studies of phytoconstituents identified in Crocus sativus, Curcuma longa, Cassia occidentalis and Moringa oleifera on thymidylate synthase - An enzyme target for anti-cancer activity
J. Appl. Pharm. Sci.
6
131-135
2016
Homo sapiens (P04818)
-
Chen, D.; Jansson, A.; Sim, D.; Larsson, A.; Nordlund, P.
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem.
292
13449-13458
2017
Homo sapiens (P04818), Homo sapiens
Antosiewicz, A.; Jarmula, A.; Przybylska, D.; Mosieniak, G.; Szczepanowska, J.; Kowalkowska, A.; Rode, W.; Ciesla, J.
Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells
J. Biomol. Struct. Dyn.
35
1474-1490
2017
Homo sapiens (P04818), Homo sapiens
Tochowicz, A.; Santucci, M.; Saxena, P.; Guaitoli, G.; Trande, M.; Finer-Moore, J.; Stroud, R.; Costi, M.
Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides
J. Med. Chem.
58
1012-1018
2015
Homo sapiens (P04818), Homo sapiens
