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Results 1 - 10 of 509 > >>
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EC Number BRENDA No. Title Journal Volume Pages Year Organism PubMed ID
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45757383 Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides J. Med. Chem. 58 1012-1018 2015 Homo sapiens 25427005
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45757061 Bacterial thymidylate synthase binds two molecules of substrate and cofactor without cooperativity J. Am. Chem. Soc. 137 14260-14263 2015 Escherichia coli 26517288
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45758166 Bacterial versus human thymidylate synthase Kinetics and functionality PLoS ONE 13 e0196506 2018 Homo sapiens 29715278
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45742057 Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target Biomedica 33 393-401 2013 Leishmania braziliensis 24652175
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45742057 Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target Biomedica 33 393-401 2013 Trypanosoma cruzi 24652175
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45742057 Biochemical characterization of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase from Leishmania (Viannia) and its evaluation as a drug target Biomedica 33 393-401 2013 Leishmania panamensis 24652175
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45755727 Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates Acta Crystallogr. Sect. F 73 336-341 2017 Homo sapiens 28580921
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45756651 Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs Eur. J. Med. Chem. 154 267-279 2018 Homo sapiens 29807332
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45756654 Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs Eur. J. Med. Chem. 171 282-296 2019 Homo sapiens 30927565
Show all pathways known for 2.1.1.45Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.45756169 Design, synthesis, anticancer evaluation and docking studies of new pyrimidine derivatives as potent thymidylate synthase inhibitors Bioorg. Chem. 91 103159 2019 Homo sapiens 31382056
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