Reference on EC 2.1.1.20 - glycine N-methyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Heady, J.E.; Kerr, S.J.
Purification and characterization of glycine N-methyltransferase
J. Biol. Chem.
248
69-72
1973
Oryctolagus cuniculus
Wagner, C.; Decha-Umphai, W.; Corbin, J.
Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand
J. Biol. Chem.
264
9638-9642
1989
BRENDA: Rattus norvegicus
Textmining: Rattus
Ogawa, H.; Fujioka, M.
Purification and properties of glycine N-methyltransferase from rat liver
J. Biol. Chem.
257
3447-3452
1982
BRENDA: Rattus norvegicus
Textmining: Rattus
Fujioka, M.; Ishiguro, Y.
Reaction of rat liver glycine methyltransferase with 5-p-fluorosulfonylbenzoyladenosine
J. Biol. Chem.
261
6346-6351
1986
BRENDA: Rattus norvegicus
Textmining: Rattus
Yeo, E.J.; Wagner, C.
Purification and properties of pancreatic glycine N-methyltransferase
J. Biol. Chem.
267
24669-24674
1992
Rattus norvegicus
Fujioka, M.; Takata, Y.; Konishi, K.; Ogawa, H.
Function and reactivity of sulfhydryl groups of rat liver glycine methyltransferase
Biochemistry
26
5696-5702
1987
BRENDA: Rattus norvegicus
Textmining: Rattus
Wagner, C.; Briggs, W.T.; Cook, R.J.
Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism
Biochem. Biophys. Res. Commun.
127
746-752
1985
BRENDA: Rattus norvegicus
Textmining: Rattus
Pattanayek, R.; Newcomer, M.E.; Wagner, C.
Crystal structure of apo-glycine N-methyltransferase (GNMT)
Protein Sci.
7
1326-1331
1998
Rattus norvegicus
Fu, Z.; Hu, Y.; Konishi, K.; Takata, Y.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Crystal structure of glycine N-methyltransferase from rat liver
Biochemistry
35
11985-11993
1996
BRENDA: Rattus norvegicus (P13255)
Textmining: Rattus
Huang, Y.; Komoto, J.; Konishi, K.; Takata, Y.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: Crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes
J. Mol. Biol.
298
149-162
2000
Rattus norvegicus (P13255)
Bhat, R.; Bresnick, E.
Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor
J. Biol. Chem.
272
21221-21226
1997
BRENDA: Rattus norvegicus
Textmining: Cricetulus griseus, Rous sarcoma virus
Bhat, R.; Wagner, C.; Bresnick, E.
The homodimeric form of glycine N-methyltransferase acts as a polycyclic aromatic hydrocarbon-binding receptor
Biochemistry
36
9906-9910
1997
BRENDA: Rattus norvegicus
Textmining: Rattus
Ogawa, H.; Gomi, T.; Imamura, T.; Kobayashi, M.; Huh, N.H.
Rat liver 4 S-benzo[a]pyrene-binding protein is distinct from glycine N-methyltransferase
Biochem. Biophys. Res. Commun.
233
300-304
1997
BRENDA: Rattus norvegicus
Textmining: Rattus, Escherichia coli
Raha, A.; Wagner, C.; MacDonald, R.G.; Bresnick, E.
Rat liver cytosolic 4 S polycyclic aromatic hydrocarbon-binding protein is glycine N-methyltransferase
J. Biol. Chem.
269
5750-5756
1994
BRENDA: Rattus norvegicus
Textmining: Rattus
Ogawa, H.; Gomi, T.; Takusagawa, F.; Fujioka, M.
Structure, function and physiological role of glycine N-methyltransferase
Int. J. Biochem. Cell Biol.
30
13-26
1998
BRENDA: Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Textmining: Rattus, Sus scrofa
Luka, Z.; Cerone, R.; Phillips, J.A.; Mudd, S.H.; Wagner, C.
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism
Hum. Genet.
110
68-74
2002
BRENDA: Homo sapiens
Textmining: Ursidae
Rowling, M.J.; McMullen, M.H.; Schalinske, K.L.
Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats
J. Nutr.
132
365-369
2002
BRENDA: Rattus norvegicus
Textmining: Rattus
Rowling, M.J.; McMullen, M.H.; Chipman, D.C.; Schalinske, K.L.
Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats
J. Nutr.
132
2545-2550
2002
BRENDA: Rattus norvegicus
Textmining: Rattus
Aida, K.; Tawata, M.; Negishi, M.; Onaya, T.
Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone
Horm. Metab. Res.
29
646-649
1997
BRENDA: Mus musculus
Textmining: Rodentia, Mus sp.
Yeo, E.J.; Wagner, C.
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
Proc. Natl. Acad. Sci. USA
91
210-214
1994
BRENDA: Rattus norvegicus
Textmining: Rattus
McMullen, M.H.; Rowling, M.J.; Ozias, M.K.; Schalinske, K.L.
Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific
Arch. Biochem. Biophys.
401
73-80
2002
BRENDA: Rattus norvegicus
Textmining: Rattus
Luka, Z.; Wagner, C.
Human glycine N-methyltransferase is unfolded by urea through a compact monomer state
Arch. Biochem. Biophys.
420
153-160
2003
Homo sapiens
Luka, Z.; Wagner, C.
Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation
Biochem. Biophys. Res. Commun.
312
1067-1072
2003
BRENDA: Homo sapiens
Textmining: Escherichia coli
Kloor, D.; Karnahl, K.; Kompf, J.
Characterization of glycine N-methyltransferase from rabbit liver
Biochem. Cell Biol.
82
369-374
2004
Oryctolagus cuniculus
Takata, Y.; Huang, Y.; Komoto, J.; Yamada, T.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
Catalytic mechanism of glycine N-methyltransferase
Biochemistry
42
8394-8402
2003
Rattus norvegicus (P13255)
Chen, S.Y.; Lin, J.R.; Darbha, R.; Lin, P.; Liu, T.Y.; Chen, Y.M.
Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway
Cancer Res.
64
3617-3623
2004
Homo sapiens
Rowling, M.J.; Schalinske, K.L.
Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells
J. Nutr.
133
3392-3398
2003
BRENDA: Rattus norvegicus
Textmining: Rattus
Ozias, M.K.; Schalinske, K.L.
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats
J. Nutr.
133
4090-4094
2003
BRENDA: Rattus norvegicus
Textmining: Rattus, Homo sapiens
Luka, Z.; Wagner, C.
Expression and purification of glycine N-methyltransferases in Escherichia coli
Protein Expr. Purif.
28
280-286
2003
BRENDA: Homo sapiens, Mus musculus, Rattus norvegicus
Textmining: Escherichia coli, Rattus
Pakhomova, S.; Luka, Z.; Grohmann, S.; Wagner, C.; Newcomer, M.E.
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes
Proteins
57
331-337
2004
BRENDA: Homo sapiens, Mus musculus
Textmining: Escherichia coli, Rattus
Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
Am. J. Physiol. Endocrinol. Metab.
291
E1235-E1242
2006
BRENDA: Rattus norvegicus
Textmining: Rattus
Huang, Y.C.; Lee, C.M.; Chen, M.; Chung, M.Y.; Chang, Y.H.; Huang, W.J.; Ho, D.M.; Pan, C.C.; Wu, T.T.; Yang, S.; Lin, M.W.; Hsieh, J.T.; Chen, Y.M.
Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer
Clin. Cancer Res.
13
1412-1420
2007
Homo sapiens
Luka, Z.; Pakhomova, S.; Loukachevitch, L.V.; Egli, M.; Newcomer, M.E.; Wagner, C.
5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase
J. Biol. Chem.
282
4069-4075
2007
BRENDA: Rattus norvegicus (P13255)
Textmining: Rattus, Areas
Beagle, B.; Yang, T.L.; Hung, J.; Cogger, E.A.; Moriarty, D.J.; Caudill, M.A.
The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake
J. Nutr.
135
2780-2785
2005
Homo sapiens
Luka, Z.; Ham, A.J.; Norris, J.L.; Yeo, E.J.; Yermalitsky, V.; Glenn, B.; Caprioli, R.M.; Liebler, D.C.; Wagner, C.
Identification of phosphorylation sites in glycine N-methyltransferase from rat liver
Protein Sci.
15
785-794
2006
BRENDA: Rattus norvegicus
Textmining: Escherichia coli, Rattus
Lee, C.M.; Chen, S.Y.; Lee, Y.C.; Huang, C.Y.; Chen, Y.M.
Benzo[a]pyrene and glycine N-methyltransferse interactions: gene expression profiles of the liver detoxification pathway
Toxicol. Appl. Pharmacol.
214
126-135
2006
Homo sapiens
Luka, Z.; Capdevila, A.; Mato, J.M.; Wagner, C.
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme
Transgenic Res.
15
393-397
2006
BRENDA: Homo sapiens, Mus musculus (Q9QXF8), Mus musculus
Textmining: Mus sp., Metazoa
Luka, Z.; Loukachevitch, L.V.; Wagner, C.
Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate
Biochim. Biophys. Acta
1784
1342-1346
2008
Rattus norvegicus
Martinez-Chantar, M.L.; Vazquez-Chantada, M.; Ariz, U.; Martinez, N.; Varela, M.; Luka, Z.; Capdevila, A.; Rodriguez, J.; Aransay, A.M.; Matthiesen, R.; Yang, H.; Calvisi, D.F.; Esteller, M.; Fraga, M.; Lu, S.C.; Wagner, C.; Mato, J.M.
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
Hepatology
47
1191-1199
2008
BRENDA: Mus musculus
Textmining: Mus sp., Homo sapiens
Liu, S.; Li, Y.; Chen, Y.; Chiang, E.; Li, A.F.; Lee, Y.; Tsai, T.; Hsiao, M.; Huang, S.; Chen, Y.A.
Glycine N-methyltransferase -/- mice develop chronic hepatitis and glycogen storage disease in the liver
Hepatology
47
768-769
2008
Mus musculus
-
Huang, Y.C.; Chen, M.; Shyr, Y.M.; Su, C.H.; Chen, C.K.; Li, A.F.; Ho, D.M.; Chen, Y.M.
Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma
J. Gastroenterol. Hepatol.
23
1384-1389
2008
Homo sapiens
Luka, Z.; Pakhomova, S.; Luka, Y.; Newcomer, M.E.; Wagner, C.
Destabilization of human glycine N-methyltransferase by H176N mutation
Protein Sci.
16
1957-1964
2007
BRENDA: Homo sapiens (Q14749), Homo sapiens
Textmining: Areas
Fang, X.; Dong, W.; Thornton, C.; Scheffler, B.; Willett, K.L.
Benzo(a)pyrene induced glycine N-methyltransferase messenger RNA expression in Fundulus heteroclitus embryos
Mar. Environ. Res.
69S1
S74-S76
2010
BRENDA: Fundulus heteroclitus (D3GAN3), Fundulus heteroclitus
Textmining: Homo sapiens
Kharbanda, K.K.; Vigneswara, V.; McVicker, B.L.; Newlaczyl, A.U.; Bailey, K.; Tuma, D.; Ray, D.E.; Carter, W.G.
Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats
Biochem. Biophys. Res. Commun.
381
523-527
2009
Rattus, Rattus norvegicus
Lee, C.M.; Shih, Y.P.; Wu, C.H.; Chen, Y.M.
Characterization of the 5 regulatory region of the human glycine N-methyltransferase gene
Gene
443
151-157
2009
Homo sapiens
Liao, Y.J.; Liu, S.P.; Lee, C.M.; Yen, C.H.; Chuang, P.C.; Chen, C.Y.; Tsai, T.F.; Huang, S.F.; Lee, Y.H.; Chen, Y.M.
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility
Int. J. Cancer
124
816-826
2009
BRENDA: Mus musculus
Textmining: Homo sapiens, Mus sp.
Luka, Z.; Mudd, S.H.; Wagner, C.
Glycine N-methyltransferase and regulation of S-adenosylmethionine levels
J. Biol. Chem.
284
22507-22511
2009
BRENDA: Danio rerio, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus (P13255)
Textmining: Mammalia
Yen, C.H.; Hung, J.H.; Ueng, Y.F.; Liu, S.P.; Chen, S.Y.; Liu, H.H.; Chou, T.Y.; Tsai, T.F.; Darbha, R.; Hsieh, L.L.; Chen, Y.M.
Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect
Toxicol. Appl. Pharmacol.
235
296-304
2009
BRENDA: Homo sapiens
Textmining: Mus musculus, Mus sp., Metazoa
Luka, Z.
Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase
Vitam. Horm.
79
325-345
2008
BRENDA: Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus, Sus scrofa (Q29555), Mus musculus (Q9QXF8), Mus musculus
Textmining: Mammalia
Wang, Y.C.; Tang, F.Y.; Chen, S.Y.; Chen, Y.M.; Chiang, E.P.
Glycine-N methyltransferase expression in HepG2 cells is involved in methyl group homeostasis by regulating transmethylation kinetics and DNA methylation
J. Nutr.
141
777-782
2011
Homo sapiens
Song, Y.H.; Shiota, M.; Kuroiwa, K.; Naito, S.; Oda, Y.
The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer
Mod. Pathol.
24
1272-1280
2011
Homo sapiens
Wang, Y.C.; Chen, Y.M.; Lin, Y.J.; Liu, S.P.; Chiang, E.P.
GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation
Mol. Med.
17
486-494
2011
Homo sapiens, Mus sp., Mus musculus
Yen, C.H.; Lu, Y.C.; Li, C.H.; Lee, C.M.; Chen, C.Y.; Cheng, M.Y.; Huang, S.F.; Chen, K.F.; Cheng, A.L.; Liao, L.Y.; Lee, Y.H.; Chen, Y.M.
Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma
Mol. Med.
18
286-296
2012
BRENDA: Homo sapiens
Textmining: Mus sp., Saccharomyces cerevisiae
Luka, Z.; Pakhomova, S.; Loukachevitch, L.; Newcomer, M.; Wagner, C.
Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate
Biochim. Biophys. Acta
1824
286-291
2012
BRENDA: Rattus norvegicus (P13255)
Textmining: Rattus, Escherichia coli
Chou, W.Y.; Zhao, J.F.; Chen, Y.M.; Lee, K.I.; Su, K.H.; Shyue, S.K.; Lee, T.S.
Role of glycine N-methyltransferase in experimental ulcerative colitis
J. Gastroenterol. Hepatol.
29
494-501
2014
Mus musculus
Ottaviani, S.; Brooke, G.N.; OHanlon-Brown, C.; Waxman, J.; Ali, S.; Buluwela, L.
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells
J. Mol. Endocrinol.
51
301-312
2013
Homo sapiens
Li, C.H.; Lin, M.H.; Chu, S.H.; Tu, P.H.; Fang, C.C.; Yen, C.H.; Liang, P.I.; Huang, J.C.; Su, Y.C.; Sytwu, H.K.; Chen, Y.M.
Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis
Mol. Med.
20
684-696
2014
BRENDA: Mus musculus (Q9QXF8)
Textmining: Mus sp.
DebRoy, S.; Kramarenko, I.I.; Ghose, S.; Oleinik, N.V.; Krupenko, S.A.; Krupenko, N.I.
A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization
PLoS ONE
8
e70062
2013
BRENDA: Homo sapiens
Textmining: Mus musculus
Tain, L.S.; Jain, C.; Nespital, T.; Froehlich, J.; Hinze, Y.; Groenke, S.; Partridge, L.
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production
Aging Cell
19
e13043
2019
BRENDA: Mus musculus (Q9QXF8), Drosophila melanogaster (Q9VG42)
Textmining: Mus sp., Drosophila
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens, Homo sapiens (P50135)
Zhang, J.; Klinman, J.P.
Convergent mechanistic features between the structurally diverse N- and O-methyltransferases glycine N-methyltransferase and catechol O-methyltransferase
J. Am. Chem. Soc.
138
9158-9165
2016
Rattus norvegicus (P13255)
Swiderek, K.; Tunon, I.; Williams,I. H.; Moliner, V.
Insights on the origin of catalysis on glycine N-methyltransferase from computational modeling
J. Am. Chem. Soc.
140
4327-4334
2018
Rattus norvegicus (P13255)
Wang, Y.; Wu, M.; Lin, Y.; Tang, F.; Ko, H.; Chiang, E.
Regulation of folate-mediated one-carbon metabolism by glycine N-methyltransferase (GNMT) and methylenetetrahydrofolate reductase (MTHFR)
J. Nutr. Sci. Vitaminol.
61
S148-S150
2015
BRENDA: Mus musculus (Q9QXF8)
Textmining: Homo sapiens, Mus sp.
Ogawa, H; Ansai, Y
Diurnal rhythms of rat liver serine dehydratase, D-site binding protein, and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels are altered by destruction of the suprachiasmatic nucleus of the hypothalamus.
Arch Biochem Biophys
321
115-22
1995
Rattus, Rodentia
Yang, D; Zhang, X; Yue, L; Hu, H; Wei, X; Guo, Q; Zhang, B; Fan, X; Xin, Y; Oh, Y; Gu, N
Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression.
Chemosphere
273
129727
2021
Mus musculus
Heady, JE
Transfer RNA methyltransferase and glycine N-methyltransferase activity during Rana pipiens development.
Dev Biol
68
624-30
1979
Lithobates pipiens
Houser, WH; Woodfork, KA
Evaluation of the 4S polycyclic aromatic hydrocarbon binding protein in the Harlan Sprague-Dawley rat.
Carcinogenesis
11
1165-9
1990
Rattus norvegicus
Ogawa, H; Konishi, K; Takata, Y; Nakashima, H; Fujioka, M
Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA.
Eur J Biochem
168
141-51
1987
Rattus, Staphylococcus aureus
Konishi, K; Fujioka, M
Rat liver glycine methyltransferase. Cooperative binding of S-adenosylmethionine and loss of cooperativity by removal of a short NH2-terminal segment.
J Biol Chem
263
13381-5
1988
Rattus
Konishi, K; Fujioka, M
Chemical modification of a functional arginine residue of rat liver glycine methyltransferase.
Biochemistry
26
8496-502
1987
Rattus
Mays, LL; Borek, E; Finch, CE
Glycine N-methyltransferase is a regulatory enzyme which increases in ageing animals.
Nature
243
411-3
1973
Metazoa
Ogawa, H; Gomi, T; Horii, T; Ogawa, H; Fujioka, M
Molecular cloning of cDNA for rat glycine methyltransferase.
Biochem Biophys Res Commun
124
44-50
1984
Rattus, Escherichia coli
Gomi, T; Ogawa, H; Fujioka, M
Purification of messenger RNA coding for glycine methyltransferase from rat liver.
Biochem Int
9
25-31
1984
Rattus, Oryctolagus cuniculus
Cook, RJ; Wagner, C
Glycine N-methyltransferase is a folate binding protein of rat liver cytosol.
Proc Natl Acad Sci U S A
81
3631-4
1984
Rattus
Ogawa, H; Fujioka, M
Induction of rat liver glycine methyltransferase by high methionine diet.
Biochem Biophys Res Commun
108
227-32
1982
Rattus
Fu, Z; Takusagawa, F; Konishi, K; Takata, Y; Fujioka, M
Crystallization and preliminary X-ray diffraction studies of glycine methyltransferase from rat liver.
J Struct Biol
113
247-9
0
Rattus
Krupenko, NI; Wagner, C
Transport of rat liver glycine N-methyltransferase into rat liver nuclei.
J Biol Chem
272
27140-6
1997
Rattus, Bos taurus, Staphylococcus aureus V8
Ogawa, H; Gomi, T; Takata, Y; Date, T; Fujioka, M
Recombinant expression of rat glycine N-methyltransferase and evidence for contribution of N-terminal acetylation to co-operative binding of S-adenosylmethionine.
Biochem J
327 ( Pt 2)
407-12
1997
Rattus, Escherichia coli
Chen, YM; Chen, LY; Wong, FH; Lee, CM; Chang, TJ; Yang-Feng, TL
Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.
Genomics
66
43-7
2000
Homo sapiens
Rowling, MJ; Schalinske, KL
Retinoid compounds activate and induce hepatic glycine N-methyltransferase in rats.
J Nutr
131
1914-7
2001
Rattus
Møller, MT; Samari, HR; Fengsrud, M; Strømhaug, PE; øStvold, AC; Seglen, PO
Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
Biochem J
373
505-13
2003
Rattus
Tanghe, KA; Garrow, TA; Schalinske, KL
Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats.
J Nutr
134
2913-8
2004
Rattus
Varela-Rey, M; Fernández-Ramos, D; MartÃnez-López, N; Embade, N; Gómez-Santos, L; Beraza, N; Vázquez-Chantada, M; RodrÃguez, J; Luka, Z; Wagner, C; Lu, SC; MartÃnez-Chantar, ML; Mato, JM
Impaired liver regeneration in mice lacking glycine N-methyltransferase.
Hepatology
50
443-52
2009
Mus sp., Metazoa
Martinez-Chantar, ML; Lu, SC; Mato, JM; Luka, Z; Wagner, C; French, BA; French, SW
The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice.
Exp Mol Pathol
88
234-7
2010
Mus sp., Transformation
Fang, X; Dong, W; Thornton, C; Willett, KL
Benzo[a]pyrene effects on glycine N-methyltransferase mRNA expression and enzyme activity in Fundulus heteroclitus embryos.
Aquat Toxicol
2010
Fundulus heteroclitus
Liu, SP; Li, YS; Lee, CM; Yen, CH; Liao, YJ; Huang, SF; Chien, CH; Chen, YM
Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice.
Int J Cancer
2010
Mus sp., Homo sapiens, Rodentia
Varela-Rey, M; Martínez-López, N; Fernández-Ramos, D; Embade, N; Calvisi, DF; Woodhoo, A; Rodríguez, J; Fraga, MF; Julve, J; Rodríguez-Millán, E; Frades, I; Torres, L; Luka, Z; Wagner, C; Esteller, M; Lu, SC; Martínez-Chantar, ML; Mato, JM
Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.
Hepatology
52
105-14
2010
Mus sp., Homo sapiens
Liao, YJ; Chen, KH; Huang, SF; Chen, TL; Wang, CK; Chien, CH; Tsai, TF; Liu, SP; Chen, YM
Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver.
Proteomics Clin Appl
4
394-406
2010
Mus musculus, Mus sp.
Chen, CY; Ching, LC; Liao, YJ; Yu, YB; Tsou, CY; Shyue, SK; Chen, YM; Lee, TS
Deficiency of Glycine N-methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-null Mice.
Mol Med
2012
Mus sp., Mus musculus
Martínez-López, N; García-Rodríguez, JL; Varela-Rey, M; Gutiérrez, V; Fernández-Ramos, D; Beraza, N; Aransay, AM; Schlangen, K; Lozano, JJ; Aspichueta, P; Luka, Z; Wagner, C; Evert, M; Calvisi, DF; Lu, SC; Mato, JM; Martínez-Chantar, ML
Hepatoma Cells From Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1.
Gastroenterology
143
787-798.e13
2012
Mus sp., Homo sapiens
Ji, Y; Nordgren, KK; Chai, Y; Hebbring, SJ; Jenkins, GD; Abo, RP; Peng, Y; Pelleymounter, LL; Moon, I; Eckloff, BW; Chai, X; Zhang, J; Fridley, BL; Yee, VC; Wieben, ED; Weinshilboum, RM
Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation.
Drug Metab Dispos
40
1984-92
2012
Homo sapiens
Chen, YM; Liao, YJ
Phosphorylated forms of GNMT in mouse liver.
J Proteomics
2013
Mus musculus
Huidobro, C; Toraño, EG; Fernández, AF; Urdinguio, RG; Rodríguez, RM; Ferrero, C; Martínez-Camblor, P; Boix, L; Bruix, J; García-Rodríguez, JL; Varela-Rey, M; Mato, JM; Martínez-Chantar, ML; Fraga, MF
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.
J Mol Med (Berl)
2013
Homo sapiens
Carrasco, M; Rabaneda, LG; Murillo-Carretero, M; Ortega-Martínez, S; Martínez-Chantar, ML; Woodhoo, A; Luka, Z; Wagner, C; Lu, SC; Mato, JM; Micó, JA; Castro, C
Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance.
Hippocampus
2014
Hippocampus, Mus sp.
Liao, YJ; Lee, TS; Twu, YC; Hsu, SM; Yang, CP; Wang, CK; Liang, YC; Chen, YA
Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver.
J Biomed Sci
23
69
2016
Mus sp.
Chang, MM; Lin, CN; Fang, CC; Chen, M; Liang, PI; Li, WM; Yeh, BW; Cheng, HC; Huang, BM; Wu, WJ; Chen, YA
Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes.
Sci Rep
8
6960
2018
Mus musculus, Mus sp.
Hughey, CC; Trefts, E; Bracy, DP; James, FD; Donahue, EP; Wasserman, DH
Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.
J Biol Chem
293
11944-11954
2018
Mus sp.
Yi, L; Mu, H; Hu, N; Sun, J; Yin, J; Dai, K; Long, D; Ding, D
Differential expression of NPM, GSTA3 and GNMT in mouse liver following long-term in vivo irradiation by means of uranium tailings.
Biosci Rep
2018
Mus musculus
Huang, JW; Chen, CJ; Yen, CH; Chen, YA; Liu, YP
Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice.
Int J Mol Sci
20
2019
Mus sp., Mus musculus
Bobi?eva, O; Bobrovs, R; Ka?epe, I; Patetko, L; Kalni?š, G; Šišovs, M; Bula, AL; Gri Nberga, S; Boroduš?is, MR; Ramata-Stunda, A; Rostoks, N; Jirgensons, A; Ta Rs, K; Jaudzems, K
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
ACS Med Chem Lett
12
1102-1107
2021
Homo sapiens
Avila, JL; Avila, A
Correlation of sinefungin susceptibility and drug-affinity for protein carboxymethyltransferase activity in American Leishmania species.
Mol Biochem Parasitol
26
69-75
1987
Leishmania, Leishmania mexicana
Chu, PY; Wu, HJ; Wang, SM; Chen, PM; Tang, FY; Chiang, EI
MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients.
Int J Mol Sci
22
2021
Homo sapiens
Shibata, K; Imanishi, D; Abe, K; Suzuki, M; Takahashi, S; Kera, Y
d-Aspartate N-methyltransferase catalyzes biosynthesis of N-methyl-d-aspartate (NMDA), a well-known selective agonist of the NMDA receptor, in mice.
Biochim Biophys Acta Proteins Proteom
1868
140527
2020
Mus sp., Mus musculus, Rattus, Mammalia
Uthus, EO; Brown-Borg, HM
Altered methionine metabolism in long living Ames dwarf mice.
Exp Gerontol
38
491-8
2003
Mus musculus, Mus sp.
Brauze, D; Malejka-Giganti, D
A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists.
Biochem J
347 Pt 3
787-95
2000
Rattus
Steele, W; Allegrucci, C; Singh, R; Lucas, E; Priddle, H; Denning, C; Sinclair, K; Young, L
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
Reprod Biomed Online
10
755-66
2005
Homo sapiens
Liu, SP; Li, YS; Chen, YJ; Chiang, EP; Li, AF; Lee, YH; Tsai, TF; Hsiao, M; Hwang, SF; Chen, YM
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Hepatology
46
1413-1425
2007
Mus sp., Homo sapiens, Mus musculus, Escherichia virus Lambda
Nishida, T; Yamaguchi, M; Tatara, Y; Kashiwakura, I
Proteomic changes by radio-mitigative thrombopoietin receptor agonist romiplostim in the blood of mice exposed to lethal total-body irradiation.
Int J Radiat Biol
96
1125-1134
2020
Mus sp.
Xue, GP; Snoswell, AM
Developmental changes in the activities of enzymes related to methyl group metabolism in sheep tissues.
Comp Biochem Physiol B
83
115-20
1986
Ovis aries, Rattus
Williams, KT; Garrow, TA; Schalinske, KL
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats.
J Nutr
138
2064-9
2008
Rattus
Strakova, J; Williams, KT; Gupta, S; Schalinske, KL; Kruger, WD; Rozen, R; Jiracek, J; Li, L; Garrow, TA
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Nutr Res
30
492-500
2010
Rattus, Mus sp.
Williams, KT; Schalinske, KL
Tissue-specific alterations of methyl group metabolism and DNA hypermethylation in the Zucker (type 2) diabetic fatty rat.
Diabetes Metab Res Rev
2011
Rattus
Whitmill, A; Kim, S; Rojas, V; Gulraiz, F; Afreen, K; Jain, M; Singh, M; Park, IW
Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection.
PLoS One
13
e0202524
2018
Hepacivirus C
Uthus, EO; Ross, SA
Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice.
J Nutr
137
1132-6
2007
animal, Mus musculus, Mus sp., Rattus
Seminotti, B; Roginski, AC; Zanatta, Â; Amaral, AU; Fernandes, T; Spannenberger, KP; da Silva, LHR; Ribeiro, RT; Leipnitz, G; Wajner, M
S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver.
J Bioenerg Biomembr
53
525-539
2021
Homo sapiens
Xue, GP; Snoswell, AM
Disturbance of methyl group metabolism in alloxan-diabetic sheep.
Biochem Int
10
897-905
1985
Ovis aries
Huang, WH; Ma, ZX; Xu, ZY; Xiong, YZ; Zuo, B
Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region.
Genet Mol Res
10
3090-7
2011
Sus scrofa, insertion sequences, Pieris brassicae
Yang, MH; Chen, YA; Tu, SC; Chi, PL; Chuang, KP; Chang, CC; Lee, CH; Chen, YL; Lee, CH; Yuan, CH; Tyan, YC
Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging.
Int J Mol Sci
22
2021
Mus sp.
Kitada, M; Ogura, Y; Monno, I; Xu, J; Koya, D
Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes.
Aging (Albany NY)
12
2020
Mus sp.
Yi, L; Li, L; Yin, J; Hu, N; Li, G; Ding, D
Proteomics analysis of liver tissues from C57BL/6J mice receiving low-dose (137)Cs radiation.
Environ Sci Pollut Res Int
23
2549-56
2016
Felis catus, Mus sp.
Doi, T; Kawata, T; Tadano, N; Iijima, T; Maekawa, A
Effect of vitamin B12 deficiency on S-adenosylmethionine metabolism in rats.
J Nutr Sci Vitaminol (Tokyo)
35
1-9
1989
Rattus
Nieman, KM; Schalinske, KL
Insulin administration abrogates perturbation of methyl group and homocysteine metabolism in streptozotocin-treated type 1 diabetic rats.
Am J Physiol Endocrinol Metab
301
E560-5
2011
Rattus
Nembhard, WN; Tang, X; Hu, Z; MacLeod, S; Stowe, Z; Webber, D; ,
Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study.
BMJ
356
j832
2017
Homo sapiens
Mudd, SH; Brosnan, JT; Brosnan, ME; Jacobs, RL; Stabler, SP; Allen, RH; Vance, DE; Wagner, C
Methyl balance and transmethylation fluxes in humans.
Am J Clin Nutr
85
19-25
2007
Homo sapiens, Mus sp., Mammalia
Mitchell, AD; Benevenga, NJ
Importance of sarcosine formation in methionine methyl carbon oxidation in the rat.
J Nutr
106
1702-13
1976
Rattus
Cook, RJ; Horne, DW; Wagner, C
Effect of dietary methyl group deficiency on one-carbon metabolism in rats.
J Nutr
119
612-7
1989
Rattus
Ogawa, H; Gomi, T; Fujioka, M
Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers.
Comp Biochem Physiol B
106
601-11
1993
Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Rattus
Balaghi, M; Horne, DW; Woodward, SC; Wagner, C
Pancreatic one-carbon metabolism in early folate deficiency in rats.
Am J Clin Nutr
58
198-203
1993
Rattus
Balaghi, M; Horne, DW; Wagner, C
Hepatic one-carbon metabolism in early folate deficiency in rats.
Biochem J
291 ( Pt 1)
145-9
1993
Rattus
Khatchadourian, C; Guillaud, J; Menezo, Y
Interactions in glycine and methionine uptake, conversion and incorporation into proteins in the preimplantation mouse embryo.
Zygote
2
301-6
1994
Mus musculus
Chen, YM; Shiu, JY; Tzeng, SJ; Shih, LS; Chen, YJ; Lui, WY; Chen, PH
Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma.
Int J Cancer
75
787-93
1998
Homo sapiens, Oryctolagus cuniculus
Uthus, EO; Ross, SA; Davis, CD
Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats.
Biol Trace Elem Res
109
201-14
2006
Rattus
Barr, J; Vázquez-Chantada, M; Alonso, C; Pérez-Cormenzana, M; Mayo, R; Galán, A; Caballería, J; Martín-Duce, A; Tran, A; Wagner, C; Luka, Z; Lu, SC; Castro, A; Le Marchand-Brustel, Y; Martínez-Chantar, ML; Veyrie, N; Clément, K; Tordjman, J; Gual, P; Mato, JM
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease.
J Proteome Res
9
4501-12
2010
Homo sapiens, Mus musculus, Metazoa, animal
Mudd, SH; Wagner, C; Luka, Z; Stabler, SP; Allen, RH; Schroer, R; Wood, T; Wang, J; Wong, LJ
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Mol Genet Metab
105
228-36
2012
Homo sapiens
Yang, CP; Wang, HA; Tsai, TH; Fan, A; Hsu, CL; Chen, CJ; Hong, CJ; Chen, YM
Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments.
Eur Neuropsychopharmacol
2012
Mus sp., Homo sapiens, Hippocampus
Fang, X; Thornton, C; Scheffler, BE; Willett, KL
Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development.
Environ Toxicol Pharmacol
36
40-50
2013
Danio rerio
Obata, F; Miura, M
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan.
Nat Commun
6
8332
2015
Drosophila, Diptera, Caenorhabditis elegans, Mammalia
Liu, Y; Zhang, Y; Tao, S; Guan, Y; Zhang, T; Wang, Z
Global DNA methylation in gonads of adult zebrafish Danio rerio under bisphenol A exposure.
Ecotoxicol Environ Saf
130
124-32
2016
Danio rerio
Xiong, L; He, L; Luo, L; Li, Y; Liao, L; Huang, R; Zhu, Z; Wang, Y
Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.
Int J Mol Sci
19
2018
Grass carp reovirus
Wu, HC; Cheng, MJ; Yen, CH; Chen, YA; Chen, YS; Chen, IS; Chang, HS
Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana.
Molecules
25
2020
Excoecaria formosana, plant
Yoshida, T; Tsuchiya, A; Kumagai, M; Takeuchi, S; Nojiri, S; Watanabe, T; Ogawa, M; Itoh, M; Takamura, M; Suganami, T; Ogawa, Y; Terai, S
Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH.
Biochem Biophys Res Commun
530
665-672
2020
Mus sp.
Raha, A; Joyce, T; Gusky, S; Bresnick, E
Glycine N-methyltransferase is a mediator of cytochrome P4501A1 gene expression.
Arch Biochem Biophys
322
395-404
1995
Rattus
Heady, JE; Kerr, SJ
Alteration of glycine N-methyltransferase activity in fetal, adult, and tumor tissues.
Cancer Res
35
640-3
1975
Rodentia
Santos, F; Amorim, A; Kömpf, J
Specific staining of glycine N-methyltransferase.
Electrophoresis
16
1898-9
1995
Homo sapiens, Sus scrofa, Oryctolagus cuniculus, Rattus
Yeo, EJ; Briggs, WT; Wagner, C
Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate.
J Biol Chem
274
37559-64
1999
Rattus
Tseng, TL; Shih, YP; Huang, YC; Wang, CK; Chen, PH; Chang, JG; Yeh, KT; Chen, YM; Buetow, KH
Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.
Cancer Res
63
647-54
2003
Homo sapiens
Liu, HH; Chen, KH; Shih, YP; Lui, WY; Wong, FH; Chen, YM
Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies.
J Biomed Sci
10
87-97
0
Homo sapiens, Mus musculus, Escherichia virus M13
Soriano, A; Castillo, R; Christov, C; Andrés, J; Moliner, V; Tuñón, I
Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis.
Biochemistry
45
14917-25
2006
Transformation
Liao, YJ; Chen, TL; Lee, TS; Wang, HA; Wang, CK; Liao, LY; Liu, RS; Huang, SF; Chen, YM
Glycine N-methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis.
Mol Med
2011
Saccharomyces cerevisiae, Homo sapiens, Mus sp.
Gomez-Santos, L; Luka, Z; Wagner, C; Fernandez-Alvarez, S; Lu, SC; Mato, JM; Martinez-Chantar, ML; Beraza, N
Inhibition of NK cells protects the liver against acute injury in the absence of GNMT.
Hepatology
2012
Homo sapiens, Mus sp.
Yen, CH; Lin, YT; Chen, HL; Chen, SY; Chen, YM
The multi-functional roles of GNMT in toxicology and cancer.
Toxicol Appl Pharmacol
266
67-75
2013
Mus musculus
Wang, YC; Lin, WL; Lin, YJ; Tang, FY; Chen, YM; Chiang, EP
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Int J Cancer
2013
Homo sapiens, Mus sp., Metazoa
Chen, M; Huang, YL; Huang, YC; Shui, IM; Giovannucci, E; Chen, YC; Chen, YM
Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study.
PLoS One
9
e94683
2014
Homo sapiens
Fernández-Álvarez, S; Gutiérrez-de Juan, V; Zubiete-Franco, I; Barbier-Torres, L; Lahoz, A; Parés, A; Luka, Z; Wagner, C; Lu, SC; Mato, JM; Martínez-Chantar, ML; Beraza, N
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Lab Invest
95
223-36
2015
Homo sapiens, Mus sp., Metazoa
Kant, R; Yen, CH; Lu, CK; Lin, YC; Li, JH; Chen, YM
Identification of 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma.
Int J Mol Sci
17
2016
Homo sapiens, Mus sp., Paeonia lactiflora
Bari?, I; Erdol, S; Saglam, H; Lovri?, M; Beluži?, R; Vugrek, O; Blom, HJ; Fumi?, K
Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders?
JIMD Rep
2016
Homo sapiens
Hung, JH; Li, CH; Yeh, CH; Huang, PC; Fang, CC; Chen, YF; Lee, KJ; Chou, CH; Cheng, HY; Huang, HD; Chen, M; Tsai, TF; Lin, AM; Yen, CH; Tsou, AP; Tyan, YC; Chen, YA
MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.
Sci Rep
8
12284
2018
Homo sapiens, Mus musculus, Mus sp.
Fang, CC; Wu, CF; Liao, YJ; Huang, SF; Chen, M; Chen, YA
AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage.
Sci Rep
8
13802
2018
Mus musculus, Mus sp., Adeno-associated virus
Kant, R; Yen, CH; Hung, JH; Lu, CK; Tung, CY; Chang, PC; Chen, YH; Tyan, YC; Chen, YA
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.
Sci Rep
9
1968
2019
Homo sapiens
Borowa-Mazgaj, B; de Conti, A; Tryndyak, V; Steward, CR; Jimenez, L; Melnyk, S; Seneshaw, M; Mirshahi, F; Rusyn, I; Beland, FA; Sanyal, AJ; Pogribny, IP
Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis.
Toxicol Sci
170
273-282
2019
Homo sapiens, Mus sp.
Liu, XQ; Jiang, L; Lei, L; Nie, ZY; Zhu, W; Wang, S; Zeng, HX; Zhang, SQ; Zhang, Q; Yard, B; Wu, YG
Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.
Clin Sci (Lond)
134
3175-3193
2020
Homo sapiens, Mus sp.
Grželj, J; Mlinari?-Raš?an, I; Marko, PB; Marovt, M; Gmeiner, T; Šmid, A
Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis.
Biomed Pharmacother
138
111456
2021
Homo sapiens
Georgieva, P; Wu, Q; McLeish, MJ; Himo, F
The reaction mechanism of phenylethanolamine N-methyltransferase: A density functional theory study.
Biochim Biophys Acta
1794
1831-7
2009
Homo sapiens
Zhang, CH; Xiao, Q; Sheng, JQ; Liu, TT; Cao, YQ; Xue, YN; Shi, M; Cao, Z; Zhou, LF; Luo, XQ; Deng, KZ; Chen, C
Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways.
Biomed Pharmacother
126
110076
2020
Rattus
Augoustides-Savvopoulou, P; Luka, Z; Karyda, S; Stabler, SP; Allen, RH; Patsiaoura, K; Wagner, C; Mudd, SH
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
J Inherit Metab Dis
26
745-59
2003
Homo sapiens
Nieman, KM; Rowling, MJ; Garrow, TA; Schalinske, KL
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid.
J Biol Chem
279
45708-12
2004
Rattus
Prudova, A; Martinov, MV; Vitvitsky, VM; Ataullakhanov, FI; Banerjee, R
Analysis of pathological defects in methionine metabolism using a simple mathematical model.
Biochim Biophys Acta
1741
331-8
2005
Homo sapiens
DiBello, PM; Dayal, S; Kaveti, S; Zhang, D; Kinter, M; Lentz, SR; Jacobsen, DW
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia.
Mol Cell Proteomics
9
471-85
2010
Homo sapiens, Metazoa, Mus musculus, Mus sp.
Pacana, T; Cazanave, S; Verdianelli, A; Patel, V; Min, HK; Mirshahi, F; Quinlivan, E; Sanyal, AJ
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
PLoS One
10
e0136822
2015
Mus sp.
Ahmadi, H; Ramezani, M; Yazdian-Robati, R; Behnam, B; Razavi Azarkhiavi, K; Hashem Nia, A; Mokhtarzadeh, A; Matbou Riahi, M; Razavi, BM; Abnous, K
Acute toxicity of functionalized single wall carbon nanotubes: A biochemical, histopathologic and proteomics approach.
Chem Biol Interact
275
196-209
2017
Electron
Villanueva, JA; Halsted, CH
Hepatic transmethylation reactions in micropigs with alcoholic liver disease.
Hepatology
39
1303-10
2004
animal
Barić, I
Inherited disorders in the conversion of methionine to homocysteine.
J Inherit Metab Dis
32
459-71
2009
Homo sapiens, Mammalia
Fernández-Ramos, D; Fernández-Tussy, P; Lopitz-Otsoa, F; Gutiérrez-de-Juan, V; Navasa, N; Barbier-Torres, L; Zubiete-Franco, I; Simón, J; Fernández, AF; Arbelaiz, A; Aransay, AM; Lavín, JL; Beraza, N; Perugorria, MJ; Banales, JM; Villa, E; Fraga, MF; Anguita, J; Avila, MA; Berasain, C; Iruzibieta, P; Crespo, J; Lu, SC; Varela-Rey, M; Mato, JM; Delgado, TC; Martínez-Chantar, ML
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Cell Death Dis
9
958
2018
Homo sapiens, Mus musculus, Mus sp., animal
Cui, Y; Xu, HF; Liu, MY; Xu, YJ; He, JC; Zhou, Y; Cang, SD
Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value.
World J Gastroenterol
25
1890-1898
2019
Homo sapiens
Fernández-Tussy, P; Fernández-Ramos, D; Lopitz-Otsoa, F; Simón, J; Barbier-Torres, L; Gomez-Santos, B; Nuñez-Garcia, M; Azkargorta, M; Gutiérrez-de Juan, V; Serrano-Macia, M; Rodríguez-Agudo, R; Iruzubieta, P; Anguita, J; Castro, RE; Champagne, D; Rincón, M; Elortza, F; Arslanow, A; Krawczyk, M; Lammert, F; Kirchmeyer, M; Behrmann, I; Crespo, J; Lu, SC; Mato, JM; Varela-Rey, M; Aspichueta, P; Delgado, TC; Martínez-Chantar, ML
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
Mol Metab
29
40-54
2019
Homo sapiens, Mus musculus, Electron
Kim, YC; Seok, S; Byun, S; Kong, B; Zhang, Y; Guo, G; Xie, W; Ma, J; Kemper, B; Kemper, JK
AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.
Nat Commun
9
540
2018
Mus sp.
Carmel, R; Melnyk, S; James, SJ
Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
Blood
101
3302-8
2003
Homo sapiens
Mato, JM; Lu, SC
Role of S-adenosyl-L-methionine in liver health and injury.
Hepatology
45
1306-12
2007
Homo sapiens
MartÃnez-López, N; Varela-Rey, M; Ariz, U; Embade, N; Vazquez-Chantada, M; Fernandez-Ramos, D; Gomez-Santos, L; Lu, SC; Mato, JM; Martinez-Chantar, ML
S-adenosylmethionine and proliferation: new pathways, new targets.
Biochem Soc Trans
36
848-52
2008
Mus musculus
Wilop, S; Fernandez, AF; Jost, E; Herman, JG; Brümmendorf, TH; Esteller, M; Galm, O
Array-based DNA methylation profiling in acute myeloid leukaemia.
Br J Haematol
2011
Homo sapiens
Lu, SC; Mato, JM
S-adenosylmethionine in liver health, injury, and cancer.
Physiol Rev
92
1515-42
2012
Homo sapiens, Mus sp.
Martínez-Uña, M; Varela-Rey, M; Cano, A; Fernández-Ares, L; Beraza, N; Aurrekoetxea, I; Martínez-Arranz, I; García-Rodríguez, JL; Buqué, X; Mestre, D; Luka, Z; Wagner, C; Alonso, C; Finnell, RH; Lu, SC; Martínez-Chantar, ML; Aspichueta, P; Mato, JM
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
Hepatology
2013
Mus sp., Metazoa
Lin, IY; Yen, CH; Liao, YJ; Lin, SE; Ma, HP; Chan, YJ; Chen, YM
Identification of FKBP11 as a biomarker for hepatocellular carcinoma.
Anticancer Res
33
2763-9
2013
Mus sp.
Obata, F; Kuranaga, E; Tomioka, K; Ming, M; Takeishi, A; Chen, CH; Soga, T; Miura, M
Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Cell Rep
7
821-33
2014
Drosophila
Wei, J; Zhang, F; Zhang, Y; Cao, C; Li, X; Li, D; Liu, X; Yang, H; Huang, L
Proteomic investigation of signatures for geniposide-induced hepatotoxicity.
J Proteome Res
13
5724-33
2014
Gardenia jasminoides Ellis, Rattus
Deminice, R; da Silva, RP; Lamarre, SG; Kelly, KB; Jacobs, RL; Brosnan, ME; Brosnan, JT
Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism.
Amino Acids
2015
Rattus
Zubiete-Franco, I; García-Rodríguez, JL; Martínez-Uña, M; Martínez-Lopez, N; Woodhoo, A; Juan, VG; Beraza, N; Lage-Medina, S; Andrade, F; Fernandez, ML; Aldámiz-Echevarría, L; Fernández-Ramos, D; Falcon-Perez, JM; Lopitz-Otsoa, F; Fernandez-Tussy, P; Barbier-Torres, L; Luka, Z; Wagner, C; García-Monzón, C; Lu, SC; Aspichueta, P; Mato, JM; Martínez-Chantar, ML; Varela-Rey, M
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
J Hepatol
64
409-18
2016
Homo sapiens, Mus sp.
Reed, MC; Gamble, MV; Hall, MN; Nijhout, HF
Mathematical analysis of the regulation of competing methyltransferases.
BMC Syst Biol
9
69
2015
Homo sapiens
Li, CH; Yen, CH; Chen, YF; Lee, KJ; Fang, CC; Zhang, X; Lai, CC; Huang, SF; Lin, HK; Arthur Chen, YM
Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.
Int J Cancer
140
2284-2297
2017
Mus sp.
Hughey, CC; James, FD; Wang, Z; Goelzer, M; Wasserman, DH
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Mol Metab
23
1-13
2019
Mus sp.
Wang, J; Li, ZX; Yang, DD; Liu, PQ; Wang, ZQ; Zeng, YQ; Chen, W
Diquat Determines a Deregulation of lncRNA and mRNA Expression in the Liver of Postweaned Piglets.
Oxid Med Cell Longev
2019
9148535
2019
Sus scrofa
Eudy, BJ; McDermott, CE; Liu, X; da Silva, RP
Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function.
Physiol Rep
8
e14576
2020
Mus sp.
Kant, R; Yang, MH; Tseng, CH; Yen, CH; Li, WY; Tyan, YC; Chen, M; Tzeng, CC; Chen, WC; You, K; Wang, WC; Chen, YL; Chen, YA
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
J Med Chem
64
8992-9009
2021
Cucumber mosaic virus
html completed
