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Literature summary for 2.1.1.20 extracted from

  • Li, C.H.; Lin, M.H.; Chu, S.H.; Tu, P.H.; Fang, C.C.; Yen, C.H.; Liang, P.I.; Huang, J.C.; Su, Y.C.; Sytwu, H.K.; Chen, Y.M.
    Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis (2014), Mol. Med., 20, 684-696.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QXF8
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General Information

General Information Comment Organism
physiological function experimental autoimmune encephalomyelitis severity is reduced significantly in Gnmt-/- mice. Gnmt-/- mice have significantly lower levels of mononuclear cell infiltration and demyelination than the wild-type mice. Expression levels of proinflammatory cytokines, including interferon-gamma and interleukin 17A, are much lower in the spinal cord of Gnmt-/- than in that of wild-type mice. Myelin oligodendrocyte glycoprotein-specific T-cell proliferation and induction of T-helper Th1 and Th17 cells are markedly suppressed in myelin oligodendrocyte glycoprotein-induced Gnmt-/- mice. The number of regulatory T cells is significantly increased in these mice Mus musculus