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Literature summary for 2.1.1.20 extracted from
- The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer (2011), Mod. Pathol., 24, 1272-1280.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate gland cancer cell | LNCaP cells and PC-3 cells | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycine N-methyltransferase | - |
Homo sapiens |
| GNMT | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | siRNA mediated GNMT knockdown results in an inhibition of proliferation, and induces G1 arrest and apoptosis in prostate cancer cell lines. Patients with high GNMT cytoplasmic expression showed significantly lower disease-free survival rates than patients with low expression | Homo sapiens |
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Release 2023.1 (January 2023)
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