Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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colon | GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions | Mus musculus | - |
leukocyte | GNMT is expressed in the epithelium of the colon under normal conditions, and with dextran sulfate sodium treatment, its expression is predominant in infiltrated leukocytes of lesions | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | mice with genetic deletion of GNMT show increased susceptibility to dextran sulfate sodium induction of colitis. Severe colonic inflammation, including increased crypt loss, leukocyte infiltration, and hemorrhage, are greater with dextran sulfate sodium treatment in GNMT?/? than wild-type mice. The expression of adhesion molecule and inflammatory mediators in the colon is significantly higher with dextran sulfate sodium treatment in GNMT?/? than wild-type mice. Loss of GNMT decreases cell apoptosis in colitis lesions with dextran sulfate sodium treatment | Mus musculus |