Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.20 extracted from

  • Luka, Z.; Capdevila, A.; Mato, J.M.; Wagner, C.
    A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme (2006), Transgenic Res., 15, 393-397.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.20

Cloned(Commentary)

Cloned (Comment) Organism
cloning of the gene and construction of enzyme deficient mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + glycine Homo sapiens key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
S-adenosyl-L-methionine + glycine Mus musculus key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio S-adenosyl-L-homocysteine + N-methylglycine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 three cases of GNMT mutations known, all suffering from mild liver disease and display elevated methionine levels
-
Mus musculus Q9QXF8 construction of GNMT knockout mice, loss of enzyme results in highly elevated levels of free methionine and S-adenosyl-L-methionine
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Mus musculus
-
pancreas
-
 Homo sapiens
-
pancreas
-
 Mus musculus
-
prostate
-
 Homo sapiens
-
prostate
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + glycine
-
 Mus musculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
S-adenosyl-L-methionine + glycine key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
S-adenosyl-L-methionine + glycine key regulatory enzyme for methyl group metabolism by regulating the S-adenosyl-L-methionine/S-adenosyl-L-homocysteine ratio Mus musculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?

Synonyms

Synonyms Comment Organism
GNMT
-
 Homo sapiens
GNMT
-
 Mus musculus