Reference on EC 1.4.3.13 - protein-lysine 6-oxidase and Organism(s) Homo sapiens and UniProt Accession Q9Y4K0
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mki, J.M.; Kivirikko, K.I.
Cloning and characterization of a fourth human lysyl oxidase isoenzyme
Biochem. J.
355
381-387
2001
Homo sapiens (P58215), Homo sapiens
Smith-Mungo, L.I.; Kagan, H.M.
Lysyl oxidase: properties, regulation and multiple functions in biology
Matrix Biol.
16
387-398
1998
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Ovis aries, Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus
Molnar, J.; Fong, K.S.K.; He, Q.P.; Hayashi, K.; Kim, Y.; Fong, S.F.T.; Fogelgren, B.; Molnarne Szauter, K.; Mink, M.; Csiszar, K.
Structural and functional diversity of lysyl oxidase and the LOX-like proteins
Biochim. Biophys. Acta
1647
220-224
2003
Homo sapiens, Mus musculus, Drosophila melanogaster (Q9N9Y8), Drosophila melanogaster (Q9V9X5)
Giampuzzi, M.; Oleggini, R.; Di Donato, A.
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved
Biochim. Biophys. Acta
1647
245-251
2003
Homo sapiens
Kagan, H.M.; Li, W.
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
J. Cell. Biochem.
88
660-672
2003
Bos taurus, Homo sapiens, Rattus norvegicus
Jung, S.T.; Kim, M.S.; Seo, J.Y.; Kim, H.C.; Kim, Y.
Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies
Protein Expr. Purif.
31
240-246
2003
Homo sapiens
Bouez, C.; Reynaud, C.; Noblesse, E.; Thepot, A.; Gleyzal, C.; Kanitakis, J.; Perrier, E.; Damour, O.; Sommer, P.
The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model
Clin. Cancer Res.
12
1463-1469
2006
Homo sapiens
Cenizo, V.; Andre, V.; Reymermier, C.; Sommer, P.; Damour, O.; Perrier, E.
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression
Exp. Dermatol.
15
574-581
2006
Homo sapiens
Lee, J.E.; Kim, Y.
A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity
J. Biol. Chem.
281
37282-37290
2006
Homo sapiens
Polgar, N.; Fogelgren, B.; Shipley, J.M.; Csiszar, K.
Lysyl oxidase interacts with hormone placental lactogen and synergistically promotes breast epithelial cell proliferation and migration
J. Biol. Chem.
282
3262-3272
2006
Homo sapiens
Hayashi, H.; Gotoh, N.; Ueda, Y.; Nakanishi, H.; Yoshimura, N.
Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population
Am. J. Ophthalmol.
145
582-585
2008
Homo sapiens
Rodriguez, C.; Alcudia, J.F.; Martinez-Gonzalez, J.; Raposo, B.; Navarro, M.A.; Badimon, L.
Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction
Atherosclerosis
196
558-564
2008
Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa
Kim, D.J.; Lee, D.C.; Yang, S.J.; Lee, J.J.; Bae, E.M.; Kim, D.M.; Min, S.H.; Kim, S.J.; Kang, D.C.; Sang, B.C.; Myung, P.K.; Park, K.C.; Yeom, Y.I.
Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells
Biochem. Biophys. Res. Commun.
373
521-527
2008
Homo sapiens
Buchinger, B.; Spitzer, S.; Karlic, H.; Klaushofer, K.; Varga, F.
Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin
Cancer Lett.
265
45-54
2008
Homo sapiens, Rattus norvegicus
Wu, G.; Guo, Z.; Chang, X.; Kim, M.S.; Nagpal, J.K.; Liu, J.; Maki, J.M.; Kivirikko, K.I.; Ethier, S.P.; Trink, B.; Sidransky, D.
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer
Cancer Res.
67
4123-4129
2007
Homo sapiens
Peinado, H.; Moreno-Bueno, G.; Hardisson, D.; Perez-Gomez, E.; Santos, V.; Mendiola, M.; de Diego, J.I.; Nistal, M.; Quintanilla, M.; Portillo, F.; Cano, A.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
Cancer Res.
68
4541-4550
2008
Homo sapiens
Kuhlenbaeumer, G.; Friedrichs, F.; Kis, B.; Berlit, P.; Maintz, D.; Nassenstein, I.; Nabavi, D.; Dittrich, R.; Stoll, M.; Ringelstein, B.
Association between single nucleotide polymorphisms in the lysyl oxidase-like 1 gene and spontaneous cervical artery dissection
Cerebrovasc. Dis.
24
343-348
2007
Homo sapiens
Shieh, T.M.; Lin, S.C.; Liu, C.J.; Chang, S.S.; Ku, T.H.; Chang, K.W.
Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis
Clin. Cancer Res.
13
4378-4385
2007
Homo sapiens
Fong, S.F.; Dietzsch, E.; Fong, K.S.; Hollosi, P.; Asuncion, L.; He, Q.; Parker, M.I.; Csiszar, K.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors
Genes Chromosomes Cancer
46
644-655
2007
Homo sapiens
Akagawa, H.; Narita, A.; Yamada, H.; Tajima, A.; Krischek, B.; Kasuya, H.; Hori, T.; Kubota, M.; Saeki, N.; Hata, A.; Mizutani, T.; Inoue, I.
Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms
Hum. Genet.
121
377-387
2007
Homo sapiens
Hewitt, A.W.; Sharma, S.; Burdon, K.P.; Wang, J.J.; Baird, P.N.; Dimasi, D.P.; Mackey, D.A.; Mitchell, P.; Craig, J.E.
Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people
Hum. Mol. Genet.
17
710-716
2008
Homo sapiens
Weise, J.B.; Csiszar, K.; Gottschlich, S.; Hoffmann, M.; Schmidt, A.; Weingartz, U.; Adamzik, I.; Heiser, A.; Kabelitz, D.; Ambrosch, P.; Goeroegh, T.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer
Int. J. Oncol.
32
317-322
2008
Homo sapiens
Pasutto, F.; Krumbiegel, M.; Mardin, C.Y.; Paoli, D.; Laemmer, R.; Weber, B.H.; Kruse, F.E.; Schloetzer-Schrehardt, U.; Reis, A.
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
Invest. Ophthalmol. Vis. Sci.
49
1459-1463
2008
Homo sapiens
Liu, Y.; Schmidt, S.; Qin, X.; Gibson, J.; Hutchins, K.; Santiago-Turla, C.; Wiggs, J.L.; Budenz, D.L.; Akafo, S.; Challa, P.; Herndon, L.W.; Hauser, M.A.; Allingham, R.R.
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations
Invest. Ophthalmol. Vis. Sci.
49
3465-3468
2008
Homo sapiens
Payne, S.L.; Hendrix, M.J.; Kirschmann, D.A.
Paradoxical roles for lysyl oxidases in cancer - a prospect
J. Cell. Biochem.
101
1338-1354
2007
Homo sapiens, Mus musculus
Postovit, L.M.; Abbott, D.E.; Payne, S.L.; Wheaton, W.W.; Margaryan, N.V.; Sullivan, R.; Jansen, M.K.; Csiszar, K.; Hendrix, M.J.; Kirschmann, D.A.
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration
J. Cell. Biochem.
103
1369-1378
2008
Homo sapiens
Goeroegh, T.; Weise, J.B.; Holtmeier, C.; Rudolph, P.; Hedderich, J.; Gottschlich, S.; Hoffmann, M.; Ambrosch, P.; Csiszar, K.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma
J. Pathol.
212
74-82
2007
Homo sapiens
Oleggini, R.; Gastaldo, N.; Di Donato, A.
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects
Matrix Biol.
26
494-505
2007
Homo sapiens
Sivakumar, P.; Gupta, S.; Sarkar, S.; Sen, S.
Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy
Mol. Cell. Biochem.
307
159-167
2008
Homo sapiens
Mori, K.; Imai, K.; Matsuda, A.; Ikeda, Y.; Naruse, S.; Hitora-Takeshita, H.; Nakano, M.; Taniguchi, T.; Omi, N.; Tashiro, K.; Kinoshita, S.
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population
Mol. Vis.
14
1037-1040
2008
Homo sapiens
Mabuchi, F.; Sakurada, Y.; Kashiwagi, K.; Yamagata, Z.; Iijima, H.; Tsukahara, S.
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome
Mol. Vis.
14
1303-1308
2008
Homo sapiens
Fuse, N.; Miyazawa, A.; Nakazawa, T.; Mengkegale, M.; Otomo, T.; Nishida, K.
Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese
Mol. Vis.
14
1338-1343
2008
Homo sapiens
Challa, P.; Schmidt, S.; Liu, Y.; Qin, X.; Vann, R.R.; Gonzalez, P.; Allingham, R.R.; Hauser, M.A.
Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma
Mol. Vis.
14
146-149
2008
Homo sapiens
Aragon-Martin, J.A.; Ritch, R.; Liebmann, J.; OBrien, C.; Blaaow, K.; Mercieca, F.; Spiteri, A.; Cobb, C.J.; Damji, K.F.; Tarkkanen, A.; Rezaie, T.; Child, A.H.; Sarfarazi, M.
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
Mol. Vis.
14
533-541
2008
Homo sapiens
Mossboeck, G.; Renner, W.; Faschinger, C.; Schmut, O.; Wedrich, A.; Weger, M.
Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population
Mol. Vis.
14
857-861
2008
Homo sapiens
Laczko, R.; Szauter, K.M.; Jansen, M.K.; Hollosi, P.; Muranyi, M.; Molnar, J.; Fong, K.S.; Hinek, A.; Csiszar, K.
Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes
Neuropathol. Appl. Neurobiol.
33
631-643
2007
Homo sapiens
Sakai, M.; Kato, H.; Sano, A.; Tanaka, N.; Inose, T.; Kimura, H.; Sohda, M.; Nakajima, M.; Kuwano, H.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma
Ann. Surg. Oncol.
16
2494-2501
2009
Homo sapiens
Erler, J.T.; Bennewith, K.L.; Cox, T.R.; Lang, G.; Bird, D.; Koong, A.; Le, Q.T.; Giaccia, A.J.
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Cancer Cell
15
35-44
2009
Homo sapiens
Lopez, B.; Querejeta, R.; Gonzalez, A.; Beaumont, J.; Larman, M.; Diez, J.
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure
Hypertension
53
236-242
2009
Homo sapiens
Coral, K.; Angayarkanni, N.; Madhavan, J.; Bharathselvi, M.; Ramakrishnan, S.; Nandi, K.; Rishi, P.; Kasinathan, N.; Krishnakumar, S.
Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment
Invest. Ophthalmol. Vis. Sci.
49
4746-4752
2008
Homo sapiens
Papachroni, K.K.; Piperi, C.; Levidou, G.; Korkolopoulou, P.; Pawelczyk, L.; Diamanti-Kandarakis, E.; Papavassiliou, A.G.
Lysyl oxidase interacts with AGEs signaling to modulate collagen synthesis in polycystic ovarian tissue
J. Cell. Mol. Med.
14
2460-2469
2010
Homo sapiens
Shieh, T.M.; Tu, H.F.; Ku, T.H.; Chang, S.S.; Chang, K.W.; Liu, C.J.
Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers
J. Oral Pathol. Med.
38
109-113
2009
Homo sapiens
Bondareva, A.; Downey, C.M.; Ayres, F.; Liu, W.; Boyd, S.K.; Hallgrimsson, B.; Jirik, F.R.
The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells
PLoS ONE
4
e5620
2009
Homo sapiens, Homo sapiens (P28300)
Saad, F.A.; Torres, M.; Wang, H.; Graham, L.
Intracellular lysyl oxidase: effect of a specific inhibitor on nuclear mass in proliferating cells
Biochem. Biophys. Res. Commun.
396
944-949
2010
Rattus norvegicus (P16636), Homo sapiens (P28300), Homo sapiens
Santhanam, A.N.; Baker, A.R.; Hegamyer, G.; Kirschmann, D.A.; Colburn, N.H.
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion
Oncogene
29
3921-3932
2010
Homo sapiens (P28300), Homo sapiens
Herwald, S.E.; Greenaway, F.T.; Lopez, K.M.
Purification of high yields of catalytically active lysyl oxidase directly from Escherichia coli cell culture
Protein Expr. Purif.
74
116-121
2010
Homo sapiens
Schietke, R.; Warnecke, C.; Wacker, I.; Schdel, J.; Mole, D.; Campean, V.; Amann, K.; Goppelt-Struebe, M.; Behrens, J.; Eckardt, K.; Wiesener, M.
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: Insights into cellular transformation processes mediated by HIF-1
J. Biol. Chem.
285
6658-6669
2010
Homo sapiens
Xu, L.; Go, E.P.; Finney, J.; Moon, H.; Lantz, M.; Rebecchi, K.; Desaire, H.; Mure, M.
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells
J. Biol. Chem.
288
5357-5363
2013
Homo sapiens (Q9Y4K0), Homo sapiens
Grimsby, J.L.; Lucero, H.A.; Trackman, P.C.; Ravid, K.; Kagan, H.M.
Role of lysyl oxidase propeptide in secretion and enzyme activity
J. Cell. Biochem.
111
1231-1243
2010
Homo sapiens (P28300)
Hutchinson, J.H.; Rowbottom, M.W.; Lonergan, D.; Darlington, J.; Prodanovich, P.; King, C.D.; Evans, J.F.; Bain, G.
Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors the identification of an inhibitor selective for LOXL2 over LOX
ACS Med. Chem. Lett.
8
423-427
2017
Homo sapiens
Wiel, C.; Augert, A.; Vincent, D.F.; Gitenay, D.; Vindrieux, D.; Le Calve, B.; Arfi, V.; Lallet-Daher, H.; Reynaud, C.; Treilleux, I.; Bartholin, L.; Lelievre, E.; Bernard, D.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis
Cell Death Dis.
4
e855
2013
Homo sapiens
Smith, M.A.; Gonzalez, J.; Hussain, A.; Oldfield, R.N.; Johnston, K.A.; Lopez, K.M.
Overexpression of soluble recombinant human lysyl oxidase by using solubility tags effects on activity and solubility
Enzyme Res.
2016
5098985
2016
Homo sapiens
Herchenhan, A.; Uhlenbrock, F.; Eliasson, P.; Weis, M.; Eyre, D.; Kadler, K.E.; Magnusson, S.P.; Kjaer, M.
Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells
J. Biol. Chem.
290
16440-16450
2015
Homo sapiens
Bhuvanasundar, R.; Ragavachetty, N.; Singh, N.; Coral, K.; Deepa, P.; Sulochana, K.
Expression, purification and characterization of a biologically active and thermally stable human lysyl oxidase
Indian J. Biochem. Biophys.
56
105-116
2019
Homo sapiens (P28300)
-
Zhang, X.; Wang, Q.; Wu, J.; Wang, J.; Shi, Y.; Liu, M.
Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state
Proc. Natl. Acad. Sci. USA
115
3828-3833
2018
Homo sapiens (Q9Y4K0), Homo sapiens
De Vita, A.; Liverani, C.; Molinaro, R.; Martinez, J.O.; Hartman, K.A.; Spadazzi, C.; Miserocchi, G.; Taraballi, F.; Evangelopoulos, M.; Pieri, F.; Bongiovanni, A.; Mercatali, L.; Tasciotti, E.; Ibrahim, T.
Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer
Sci. Rep.
11
5107
2021
Homo sapiens (Q08397)
