Activating Compound | Comment | Organism | Structure |
---|---|---|---|
transforming growth factor-beta1 | fibrogenic cytokine, strongly promotes enzyme expression in fibroblasts of neonatal rat lung, human embryos and rat vascular smooth muscle cells | Homo sapiens | |
transforming growth factor-beta1 | fibrogenic cytokine, strongly promotes enzyme expression in fibroblasts of neonatal rat lung, human embryos and rat vascular smooth muscle cells | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | cutis laxa, indicated by hyperextensible skin with marked deficiency of skin elastic fibers, is caused by deficiency of lysyl oxidase expression. Fibrosis is a symptom of scleroderma, where lysyl oxidase is markedly elevated in affected tissues. Menkes syndrome may involve abnormalities in the expression of several genes coding for connective tissue proteins | Mammalia |
medicine | increase in the expression of lysyl oxidase during wound healing in skin and in aorta, lung and skin of developing and aging rats. Implication of lysyl oxidase as a target gene for IRF-1 in tumor suppression. Lysly oxidase has unusual and important roles in cellular homeostasis | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
- |
Gallus gallus |
- |
Mus musculus |
- |
Homo sapiens |
expressed in Escherichia coli | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
basic fibroblast growth factor | reduces enzyme expression in osteogenic cells | Mammalia | |
beta-aminopropionitrile | - |
Gallus gallus | |
beta-aminopropionitrile | irreversible inhibitor | Rattus norvegicus | |
cycloheximide | - |
Gallus gallus | |
cycloheximide | prevents stimulation by transforming growth factor-beta1 | Mammalia |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Gallus gallus | |
Cu2+ | copper-binding and -dependent | Homo sapiens | |
Cu2+ | tightly bound in a tetragonally distorted, octahedrally coordinated ligand field, one per mol | Mammalia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
x * 46000, predicted, x * 32000, SDS-PAGE | Bos taurus |
32000 | - |
x * 32000, catalytically active enzyme after proteolytic cleavage | Mammalia |
32000 | - |
x * 32000, catalytically active enzyme after proteolytic cleavage | Rattus norvegicus |
46000 | - |
x * 46000, predicted, x * 32000, SDS-PAGE | Bos taurus |
50000 | - |
x * 50000, preproprotein | Mammalia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mammalia | - |
expression is sensitively modulated by specific cytokines, growth factors and related intercellular molecular messengers | - |
Mus musculus | - |
- |
- |
Ovis aries | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
glycoprotein | N-glycosylated as 50 kDa preproprotein | Mammalia |
proteolytic modification | proteolytically cleaved to the 32 kDa catalytically active enzyme | Mammalia |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | preprotein, lysyl oxidase gene family, amine oxidation through ping pong bi ter kinetic mechanism | Mammalia |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Gallus gallus | - |
aorta | - |
Rattus norvegicus | - |
aorta | - |
Bos taurus | - |
basal cell | - |
Mammalia | - |
biliary epithelium | - |
Mammalia | - |
chondrocyte | - |
Mammalia | - |
endothelium | - |
Mammalia | - |
fibroblast | - |
Mammalia | - |
fibroblast | - |
Homo sapiens | - |
glomerular epithelium | - |
Mammalia | - |
lung | - |
Rattus norvegicus | - |
skin | - |
Homo sapiens | - |
skin | - |
Rattus norvegicus | - |
smooth muscle | - |
Mammalia | - |
smooth muscle | nucleus | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-L-lysyl-peptide + O2 + H2O | - |
Gallus gallus | peptidyl-L-allysyl-peptide + NH3 + H2O2 | - |
? | |
peptidyl-L-lysyl-peptide + O2 + H2O | crosslinkage in fibrillar collagen and elastin | Mammalia | peptidyl-L-allysyl-peptide + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Gallus gallus |
? | - |
Homo sapiens |
? | x * 46000, predicted, x * 32000, SDS-PAGE | Bos taurus |
? | x * 32000, catalytically active enzyme after proteolytic cleavage | Mammalia |
? | x * 32000, catalytically active enzyme after proteolytic cleavage | Rattus norvegicus |
? | x * 50000, preproprotein | Mammalia |
Synonyms | Comment | Organism |
---|---|---|
lysyl oxidase | - |
Mammalia |
lysyl oxidase | amine oxidase, oxidative deamination | Gallus gallus |
lysyl oxidase | amine oxidase, oxidative deamination | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
lysyltyrosyl quinone | - |
Homo sapiens | |
lysyltyrosyl quinone | prosthetic group | Mammalia | |
trihydroxyphenylalanine quinone | - |
Saccharomyces cerevisiae |