Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | stromal tissue and ovarian follicle, polycystic ovarian tissue | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
LOX | - |
Homo sapiens |
lysyl oxidase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is upregulated in polycystic ovarian tissue by LOX promoter binding of transcription factors, e.g. NF-kappaB and activator protein-1, induced in advanced glycation end product, AEG, signaling, overview | up |
General Information | Comment | Organism |
---|---|---|
malfunction | excess collagen deposition in ovarian stroma in polycystic ovary syndrome involves increased enzyme activity due to stimulation by advenced glycation end products | Homo sapiens |
physiological function | the enzyme is involved n collagen synthesis. It catalyzes the collagen and elastin cross-linking and plays an essential role in coordinating the control of ovarian extracellular matrix during ovarian follicle development, overview | Homo sapiens |