Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor-diffusion method at 18°C, crystal structure of the enzyme at 2.4 A resolution | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | copper loading activates hLOXL2 and supports lysyl tyrosylquinone formation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[collagen]-L-lysine + O2 + H2O | Homo sapiens | the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix | [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? | |
[elastin]-L-lysine + O2 + H2O | Homo sapiens | the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix | [elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y4K0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[collagen]-L-lysine + O2 + H2O | the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix | Homo sapiens | [collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? | |
[elastin]-L-lysine + O2 + H2O | the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix | Homo sapiens | [elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Loxl2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix | Homo sapiens |