6.3.2.25: tubulin-tyrosine ligase

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For detailed information about tubulin-tyrosine ligase, go to the full flat file.

Word Map on EC 6.3.2.25

6.3.2.25

microtubule

detyrosinated

hardware

non-sentinel

d-roms

polyglutamylation

analysis

synthesis

Reaction

Synonyms

Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.25 tubulin-tyrosine ligase

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Results	in table
2	Activating Compound
178	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
174	Disease/ Diagnostics
9	General Information
2	General Stability
30	Inhibitors
1	Ki Value [mM]
14	KM Value [mM]
4	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
40	Organism
5	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
9	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
40	Reference
43	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
46	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
1	Systematic Name

Molecular Weight

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Molecular Weight on EC 6.3.2.25 - tubulin-tyrosine ligase

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35000

Bos taurus

gel filtration, MW of enzyme in crude extract, the MW of the purified enzyme is 150000. Addition of pure dimeric tubulin to the 35000 MW enzyme converts it back to the larger form which is apparently a stoichiometric 1:1 complex of tubulin and the 35000 MW enzyme

37000

gel filtration

40000

43000

43425

45000

loaded with binding partners, mass spectrometry

709442

46000

Sus scrofa

1 * 46000, SDS-PAGE

1183

additional information

Sus scrofa

two-domain structure: the two domains interact tightly under physiological conditions. The 30000 MW domain carries the binding sites for beta-tubulin and ATP. The 14000 MW domain can possibly form an additional part of the catalytic site

1173