6.3.2.25: tubulin-tyrosine ligase

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For detailed information about tubulin-tyrosine ligase, go to the full flat file.

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Synonyms

Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.25 tubulin-tyrosine ligase

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Results	in table
2	Activating Compound
178	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
174	Disease/ Diagnostics
9	General Information
2	General Stability
30	Inhibitors
1	Ki Value [mM]
14	KM Value [mM]
4	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
40	Organism
5	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
9	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
40	Reference
43	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
46	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
1	Systematic Name

KM Value

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KM Value on EC 6.3.2.25 - tubulin-tyrosine ligase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.002

alpha-tubulin

Bos taurus

-

below 0.002 mM

1175

0.014

ATP

Bos taurus

-

-

1178

0.186

L-Dopa

Sus scrofa

-

-

1184

0.16

L-hydroxyphenylalanine

Bos taurus

-

-

1175

0.432 - 2.9

L-Phe

2 entries

0.017 - 0.045

L-Tyr

3 entries

0.0068

L-tyrosine

Sus scrofa

-

37°C

650316

8

tyramine

Bos taurus

-

-

1175

0.0019

untyrosinated tubulin

Bos taurus

-

-

1178

0.432

L-Phe

Sus scrofa

-

-

1166, 1184

2.9

L-Phe

Bos taurus

-

-

1175

0.017

L-Tyr

Bos taurus

-

-

1178

0.0254

L-Tyr

Sus scrofa

-

-

1166, 1184

0.045

L-Tyr

Bos taurus

-

-

1175