6.3.2.25: tubulin-tyrosine ligase

This is an abbreviated version!
For detailed information about tubulin-tyrosine ligase, go to the full flat file.

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Synonyms

Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.25 tubulin-tyrosine ligase

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Results	in table
2	Activating Compound
178	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
174	Disease/ Diagnostics
9	General Information
2	General Stability
30	Inhibitors
1	Ki Value [mM]
14	KM Value [mM]
4	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
40	Organism
5	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
9	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
40	Reference
43	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
46	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 6.3.2.25 - tubulin-tyrosine ligase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + detyrosinated alpha-tubulin + L-Tyr

?

5 entries

ATP + detyrosinated alpha-tubulin + L-Tyr

alpha-tubulin + ADP + phosphate

2 entries

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

11 entries

additional information

?

-

2 entries

ATP + detyrosinated alpha-tubulin + L-Tyr

?

Bos taurus

-

posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin

1172

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

?

Bos taurus

-

posttranslational modification of tubulin with potential significance for the regulation of microtubule assembly or function

1175

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

?

Caenorhabditis elegans

-

activity increases from the embryonic stage to the fourth larval stage L4, decreases from L4 to adult and to aged nematodes with only qualitative alterations in substrate specificity

1176

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

?

Crithidia fasciculata

-

terminal Tyr is present in about 5% of flagellar alpha-chain from cells in stationary phase and 20% from cells from midlog phase. None is detected in tubulin from cytosol or the subpellicular corset. In contrast to mammalian cells, in which higher state of tyrosinylation characterizes recently assembled or unstable microtubules, terminal Tyr is present only in the most stable polymer, the flagellar double microtubules

1169

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

?

Sus scrofa

-

posttranslational addition of Tyr to the carboxyterminal end of detyrosinated alpha-tubulin

1172

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

alpha-tubulin + ADP + phosphate

Homo sapiens

Q8NG68

the enzyme plays a vital role in neuronal organization

663250

-

-

?

ATP + detyrosinated alpha-tubulin + L-Tyr

alpha-tubulin + ADP + phosphate

Mus musculus

-

the enzyme plays a vital role in neuronal organization

663250

-

-

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Bos taurus

-

-

728153

-

-

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Gallus gallus

E1BQ43

tubuline alpha/beta-dimers, no activity with tyrosinate polymerized microtubules in which the tubulin subunits adopt a straighter configuration

728025

-

-

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Homo sapiens

-

-

652600

-

652600

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Mus musculus

-

-

686295, 728025

-

-

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Mus musculus

-

tubulin tyrosination is a major factor affecting the recruitment of cytoskeleton-associated protein glycine-rich proteins at microtubule plus ends

675003

-

-

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Rattus norvegicus

Q9QXJ0

-

653353

-

653353

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Sus scrofa

-

-

650316

-

650316

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Sus scrofa

-

-

650790

-

650790

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Sus scrofa

-

-

652600

-

652600

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Sus scrofa

-

-

653350

-

653350

?

ATP + detyrosinated alpha-tubulin + L-tyrosine

alpha-tubulin + ADP + phosphate

Sus scrofa

-

-

728153

-

-

?

additional information

?

-

Homo sapiens

-

the testis-specific apoptosis related gene TTL.6 (member of the tubulin-tyrosine ligase family) undergoes adaptive evolution in the lineage leading to humans

673831

-

-

?

additional information

?

-

Mus musculus

-

microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination, interaction between MAP1B and TTL is not regulated by MAP1B phosphorylation, overview

686295

-

-

?