6.3.2.25: tubulin-tyrosine ligase

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For detailed information about tubulin-tyrosine ligase, go to the full flat file.

Reaction

Synonyms

Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.25 tubulin-tyrosine ligase

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Results	in table
2	Activating Compound
178	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
174	Disease/ Diagnostics
9	General Information
2	General Stability
30	Inhibitors
1	Ki Value [mM]
14	KM Value [mM]
4	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
40	Organism
5	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
9	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
40	Reference
43	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
46	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
1	Systematic Name

Cloned

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Cloned on EC 6.3.2.25 - tubulin-tyrosine ligase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Sus scrofa

-

1172, 486115

cloning of cDNA

Sus scrofa

-

652600

expression in Escherichia coli

Sus scrofa

-

650316

expression in HEK293T cells

Homo sapiens

Q8NG68

663250

expression of GST-tagged TTL in Escherichia coli strain BL21, co-expression of TTL with MAP1B in COS-7 cells inducing an increase in tyrosinated microtubules

Mus musculus

-

686295

expression of TTL in Escherichia coli and Sf9 insect cells

Sus scrofa

-

653350

transient transfection of a TTL cDNA portion that encodes the beta-tubulin binding domain but lacks the catalytic domain into CHO-K1 cells

Rattus norvegicus

Q9QXJ0

653353