6.3.2.25: tubulin-tyrosine ligase

This is an abbreviated version!
For detailed information about tubulin-tyrosine ligase, go to the full flat file.

Word Map on EC 6.3.2.25

6.3.2.25

microtubule

detyrosinated

hardware

non-sentinel

d-roms

polyglutamylation

analysis

synthesis

Reaction

Synonyms

Synthetase, tubulin-tyrosine, TTL, TTLase, tubulin tyrosine ligase, tubulin-tyrosine ligase, tubulin-tyrosine-ligase, Tubulin:tyrosine ligase, tubuline-tyrosine ligase, Tyrosyltubulin ligase

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.25 tubulin-tyrosine ligase

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Results	in table
2	Activating Compound
178	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
174	Disease/ Diagnostics
9	General Information
2	General Stability
30	Inhibitors
1	Ki Value [mM]
14	KM Value [mM]
4	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
40	Organism
5	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
9	Protein Variants
8	Purification (Commentary)
3	Reaction
1	Reaction Type
40	Reference
43	Source Tissue
5	Specific Activity [micromol/min/mg]
5	Storage Stability
46	Substrates and Products (Substrate)
7	Subunits
36	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 6.3.2.25 - tubulin-tyrosine ligase

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(1R,4aS,6R,8S)-6,8-dihydroxy-5-[(3E)-5-hydroxy-5-(3-hydroxy-5-oxo-2,5-dihydrofuran-2-yl)-3-methylpent-3-en-1-yl]-4a,6-dimethyldecahydronaphthalene-1-carboxylic acid

Homo sapiens

increases the non-tyrosinatable form of alpha-tubulin in human cancer cell cultures indicating to act as an inhibitor of TTL

709442

3-nitro-L-tyrosine

Sus scrofa

50% inhibition of tyrosine incorporation at 50fold higher concentrations of nitrotyrosine

650316

ADP

Bos taurus

competitive with respect to ATP, non-competitive with respect to tubulin and L-Tyr

alpha-L-Glu-L-Tyr

AMP

diiodotyrosine

L-Ala-L-Tyr

L-Dopa

L-hydroxyphenylalanine

L-Phe

L-Tyr

L-Tyr-Gly

L-Tyr-L-Ala

L-Tyr-L-Glu

L-Tyr-L-Tyr

monoiodotyrosine

NEM

p-chloromercuriphenyl sulfonic acid

p-Iodophenylalanine

phosphate

very weak

stathmin

tyramine

tyrosinated tubulin

very weak

additional information

Sus scrofa

no inhibition by thyronine and its iodinated derivatives

1168