6.2.1.7: cholate-CoA ligase
This is an abbreviated version!
For detailed information about cholate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.7
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6.2.1.7
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n-acyltransferase
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acid-coa
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synthetases
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taurine
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triton
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trihydroxycoprostanoyl-coa
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deoxycholate
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rough
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n-ethylmaleimide
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cholyl-coa
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unconjugated
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detergent-solubilized
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analysis
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coash
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chenodeoxycholate
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eubacterium
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delipidated
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lithocholate
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intrahepatic
- 6.2.1.7
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n-acyltransferase
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acid-coa
- synthetases
- taurine
- triton
- trihydroxycoprostanoyl-coa
- deoxycholate
-
rough
- n-ethylmaleimide
- cholyl-coa
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unconjugated
-
detergent-solubilized
- analysis
- coash
- chenodeoxycholate
-
eubacterium
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delipidated
- lithocholate
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intrahepatic
Reaction
Synonyms
BAL, bile acid coenzyme A ligase, Bile acid coenzyme A synthetase, Bile acid-coenzyme A ligase, Bile acid:CoA ligase, CCL, Cholate thiokinase, Cholic acid:CoA ligase, Cholic thiokinase, Choloyl coenzyme A synthetase, Choloyl-CoA synthetase, EC 6.2.1.29, Synthetase, choloyl coenzyme A
ECTree
6.2.1.7 cholate-CoA ligaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 6.2.1.7 - cholate-CoA ligase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
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-
-
?
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA
AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
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-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
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-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
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-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
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-
-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
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-
-
?
ATP + chenodeoxycholate + CoA
AMP + diphosphate + chenodeoxycholoyl-CoA
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-
-
-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
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initial step in the bile acid 7alpha-dehydroxylation pathway
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-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
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initial step in the bile acid 7alpha-dehydroxylation pathway
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-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
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re-activation and re-conjugation of bile acids
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?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
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kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids
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-
?
ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
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choloyl-CoA synthetase is probably the rate limiting enzyme in the two-enzyme sequence catalyzing conjugation of bile acids
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-
?
ATP + deoxycholate + CoA
AMP + diphosphate + deoxycholoyl-CoA
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-
-
-
?
additional information
?
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the enzyme requires a C-24 bile acid with a free carboxyl group
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-
?
additional information
?
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the enzyme requires a C-24 bile acid with a free carboxyl group
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-
?
additional information
?
-
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enzyme additionally activates fatty acids
-
?
