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6.2.1.7: cholate-CoA ligase

This is an abbreviated version!
For detailed information about cholate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.7

Reaction

ATP
+
cholate
+
CoA
=
AMP
+
diphosphate
+
choloyl-CoA

Synonyms

BAL, bile acid coenzyme A ligase, Bile acid coenzyme A synthetase, Bile acid-coenzyme A ligase, Bile acid:CoA ligase, CCL, Cholate thiokinase, Cholic acid:CoA ligase, Cholic thiokinase, Choloyl coenzyme A synthetase, Choloyl-CoA synthetase, EC 6.2.1.29, Synthetase, choloyl coenzyme A

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.7 cholate-CoA ligase

Activating Compound

Activating Compound on EC 6.2.1.7 - cholate-CoA ligase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
-
activation
-
dithiothreitol
-
activation
NEM
-
biphasic effect: at short reaction times ligase activity increases, but further reaction leads to nearly complete inactivation
Phospholipid
-
addition of phospholipids is necessary to restore the activity of the delipidated enzyme stabilized by high concentrations of glucose and sucrose
Triton X-100
-
activation