Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid | 0.005 mM, 63% inhibition of the activity with chenodeoxycholate | Rattus norvegicus | |
cholic acid | 0.02 mM, 20% inhibition of the activity with chenodeoxycholate | Rattus norvegicus | |
EDTA | - |
Rattus norvegicus | |
lithocholic acid | 0.005 mM, 95% inhibition of the activity with chenodeoxycholate | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
chenodeoxycholate | - |
Rattus norvegicus | |
0.548 | - |
ATP | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
x * 65000, SDS-PAGE | Rattus norvegicus |
243000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.385 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + chenodeoxycholate + CoA | - |
Rattus norvegicus | AMP + diphosphate + chenodeoxycholoyl-CoA | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
bile acid coenzyme A ligase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
8 | 9.6 | pH 8.0: about 75% of maximal activity, pH 9.6: about 75% of maximal activity | Rattus norvegicus |