Literature summary for 6.2.1.7 extracted from

Falany, C.N.; Xie, X.; Wheeler, J.B.; Wang, J.; Smith, M.; He, D.; Barnes, S.
Molecular cloning and expression of rat liver bile acid CoA ligase (2002), J. Lipid Res., 43, 2062-2071.

Search for more literature for 6.2.1.7

Cloned(Commentary)

Cloned (Comment)	Organism
expression of rBAL in Sf9 insect cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Brij-58	-	Rattus norvegicus
cholic acid	0.02 mM, 24% inhibition	Rattus norvegicus
deoxycholic acid	0.02 mM, 60% inhibition	Rattus norvegicus
lithocholic acid	0.02 mM, 96% inhibition	Rattus norvegicus
norcholic acid	0.02 mM, 18% inhibition	Rattus norvegicus
oleic acid	-	Rattus norvegicus
palmitoleic acid	-	Rattus norvegicus
trihydroxycoprostanoic acid	0.02 mM, 24% inhibition	Rattus norvegicus
Triton X-100	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.032	-	chenodeoxycholate	native recombinant enzyme expressed in Sf9 microsomes	Rattus norvegicus
0.064	-	chenodeoxycholate	His-tagged recombinant enzyme	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + chenodeoxycholate + CoA	-	Rattus norvegicus	AMP + diphosphate + chenodeoxycholoyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
BAL	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)