6.2.1.16: acetoacetate-CoA ligase

This is an abbreviated version!
For detailed information about acetoacetate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.16

6.2.1.16

ketone

cholesterol

lipogenesis

body-utilizing

lipogenic

thiolase

hmg-coa

3-hydroxybutyrate

coa-transferase

cholestyramine

zoogloea

ramigera

srebp-2

Reaction

Synonyms

Aacl, AACS, Acetoacetate--CoA ligase, Acetoacetyl CoA synthetase, Acetoacetyl-CoA ligase, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, Acetoacetyl-coenzyme A synthetase, acsA1, SlAacS, Synthetase, acetoacetyl coenzyme A

ECTree

6 Ligases

6.2 Forming carbon-sulfur bonds

6.2.1 Acid-thiol ligases

6.2.1.16 acetoacetate-CoA ligase

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Results	in table
1	Activating Compound
6327	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
12	Disease/ Diagnostics
6	Expression
24	General Information
4	General Stability
4	Inhibitors
3	kcat/KM [mM/s]
11	KM Value [mM]
13	Localization
25	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
361	Organism
4	Pathway
8	pH Optimum
2	pH Range
5	Posttranslational Modification
8	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
49	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
43	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 6.2.1.16 - acetoacetate-CoA ligase

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ATP + acetate + CoA

AMP + diphosphate + acetyl-CoA

Rattus norvegicus

45% of the activity relative to acetoacetate

648

ATP + acetoacetate + CoA

AMP + diphosphate + acetoacetyl-CoA

28 entries

ATP + L-3-hydroxybutanoate + CoA

AMP + diphosphate + L-3-hydroxybutyryl-CoA

4 entries

ATP + L-3-hydroxybutyrate + CoA

AMP + diphosphate + L-3-hydroxybutyryl-CoA

Sinorhizobium meliloti

653080

additional information

6 entries