6.2.1.16: acetoacetate-CoA ligase

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For detailed information about acetoacetate-CoA ligase, go to the full flat file.

Reaction

Synonyms

Aacl, AACS, Acetoacetate--CoA ligase, Acetoacetyl CoA synthetase, Acetoacetyl-CoA ligase, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, Acetoacetyl-coenzyme A synthetase, acsA1, SlAacS, Synthetase, acetoacetyl coenzyme A

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.16 acetoacetate-CoA ligase

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Results	in table
1	Activating Compound
6327	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
12	Disease/ Diagnostics
6	Expression
24	General Information
4	General Stability
4	Inhibitors
3	kcat/KM [mM/s]
11	KM Value [mM]
13	Localization
25	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
361	Organism
4	Pathway
8	pH Optimum
2	pH Range
5	Posttranslational Modification
8	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
49	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
43	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Engineering

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Engineering on EC 6.2.1.16 - acetoacetate-CoA ligase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

N320Q

Mus musculus

Q9D2R0

site-directed mutagenesis, the mutant is not cleaved by legumain

744906

N449Q

Mus musculus

Q9D2R0

site-directed mutagenesis, the mutant is not cleaved by legumain

744906

N500Q

Mus musculus

Q9D2R0

site-directed mutagenesis, the mutant is cleaved by legumain

744906

N503Q

Mus musculus

Q9D2R0

site-directed mutagenesis, the mutant iscleaved by legumain, but the mutation abolishes the formation of the 56-kDa band through cleavage by legumain

744906

N545Q

Mus musculus

Q9D2R0

site-directed mutagenesis, catalytically inactive mutant, that is cleaved by legumain

744906

N547Q

Mus musculus

Q9D2R0

site-directed mutagenesis, the mutant iscleaved by legumain, but the mutation abolishes the formation of the 56-kDa band through cleavage by legumain

744906

additional information

2 entries

additional information

Mus musculus

-

enzyme downregulation by shAACS targeted lentivirus expression in 3T3-L1 cells

727116

additional information

Rattus norvegicus

-

expression of a Streptomyces mevalonate pathway gene cluster starting from HMG-CoA synthase and including isopentenyl diphosphate isomerase, idi, type 2 gene and the yeast idi type 1 and rat acetoacetate-CoA ligase genes in Escherichia coli, overview

690593