6.2.1.16: acetoacetate-CoA ligase

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For detailed information about acetoacetate-CoA ligase, go to the full flat file.

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Synonyms

Aacl, AACS, Acetoacetate--CoA ligase, Acetoacetyl CoA synthetase, Acetoacetyl-CoA ligase, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, Acetoacetyl-coenzyme A synthetase, acsA1, SlAacS, Synthetase, acetoacetyl coenzyme A

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.16 acetoacetate-CoA ligase

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Results	in table
1	Activating Compound
6327	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
12	Disease/ Diagnostics
6	Expression
24	General Information
4	General Stability
4	Inhibitors
3	kcat/KM [mM/s]
11	KM Value [mM]
13	Localization
25	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
361	Organism
4	Pathway
8	pH Optimum
2	pH Range
5	Posttranslational Modification
8	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
49	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
43	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Disease

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Disease on EC 6.2.1.16 - acetoacetate-CoA ligase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Neoplasms

Role of acetoacetyl-CoA synthetase in acetoacetate utilization by tumor cells.

6147189

Neuroblastoma

Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.

29137983

Non-alcoholic Fatty Liver Disease

Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens.

28077733

Obesity

Genetic obesity affects neural ketone body utilization in the rat brain.

19219059

Obesity

High-fat diet-induced obesity stimulates ketone body utilization in osteoclasts of the mouse bone.

27021680

Obesity

Leptin controls ketone body utilization in hypothalamic neuron.

21194556

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