6.2.1.16: acetoacetate-CoA ligase

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For detailed information about acetoacetate-CoA ligase, go to the full flat file.

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Synonyms

Aacl, AACS, Acetoacetate--CoA ligase, Acetoacetyl CoA synthetase, Acetoacetyl-CoA ligase, Acetoacetyl-CoA synthase, Acetoacetyl-CoA synthetase, Acetoacetyl-coenzyme A synthetase, acsA1, SlAacS, Synthetase, acetoacetyl coenzyme A

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.16 acetoacetate-CoA ligase

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Results	in table
1	Activating Compound
6327	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
8	Cofactor
1	Crystallization (Commentary)
12	Disease/ Diagnostics
6	Expression
24	General Information
4	General Stability
4	Inhibitors
3	kcat/KM [mM/s]
11	KM Value [mM]
13	Localization
25	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
361	Organism
4	Pathway
8	pH Optimum
2	pH Range
5	Posttranslational Modification
8	Protein Variants
8	Purification (Commentary)
1	Reaction
1	Reaction Type
35	Reference
49	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
43	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 6.2.1.16 - acetoacetate-CoA ligase

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.00424

Sinorhizobium meliloti

Q9Z3R3

22°C, pH 8.0

653079

2.3

Rattus norvegicus

-

-

647

2.63

Rattus norvegicus

-

-

647

4.91 - 6.8

Streptomyces lividans

D6EQU8

purified recombinant enzyme, pH 7.5, 30°C

746014

52.2

Zoogloea ramigera

-

-

649

additional information

2 entries

additional information

Rattus norvegicus

-

in male rat liver, specific activity reaches a maximum at 4 weeks of age, then gradually decreases, in female rats, the maximum activity is reached at 6 weeks of age, and it is 3fold higher than in males

650484

additional information

Rattus norvegicus

-

streptozotocin-induced diabetes results in a decrease in acetoacetyl-CoA synthetase specific activity in rat liver, but not in other acetoacetyl-CoA synthetase containing tissues, e.g kidney, lung or brain, hepatic acetoacetyl-CoA synthetase activity is 8fold higher in rats fed with cholestyramine and pravastatin

649794