6.2.1.1: acetate-CoA ligase

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For detailed information about acetate-CoA ligase, go to the full flat file.

Reaction

Synonyms

ACAS, ACD, AceCS, AceCS1, AceCS2, Acetate thiokinase, Acetate--CoA ligase, acetate:CoA ligase (AMP-forming), Acetic thiokinase, Acetyl activating enzyme, Acetyl CoA ligase, Acetyl CoA synthase, acetyl CoA synthetase, acetyl coenzyme A synthase/carbon monoxide dehydrogenase, Acetyl coenzyme A synthetase, Acetyl-CoA synthase, Acetyl-CoA synthetase, acetyl-CoA synthetase 2, acetyl-CoA synthetase short-chain family member 2, Acetyl-coenzyme A synthase, acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-coenzyme A synthetase, ACS, ACS/CODH, ACS1, Acs1p, ACS2, Acs2p, AcsA, acsA1, AcsA2, AcsA3, ACSS2, Acyl-activating enzyme, Acyl-CoA synthetase, adenosine monophosphate-forming acetyl-CoA synthetase, ADP-forming acetyl-CoA synthetase, AF-ACS2, AMP acetyl-coenzyme A synthetase, AMP-Acs, AMP-dependent ACS, AMP-forming acetyl coenzyme A synthetase, AMP-forming acetyl-CoA synthetase, AMP-forming ACS, AMP-forming CoA ligase, carbon monoxide dehydrogenase/acety-coenzyme A synthase, carbon monoxide dehydrogenase/acetyl-CoA synthase, CODH/ACS, More, MT-ACS1, mtCODH/ACS, Mthe_1194, SeAcs, Short chain fatty acyl-CoA synthetase, Short-chain acyl-coenzyme A synthetase, Synthetase, acetyl coenzyme A

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.1 acetate-CoA ligase

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Results	in table
11	Activating Compound
37970	AA Sequence
3	Application
1	CAS Registry Number
32	Cloned(Commentary)
29	Cofactor
5	Crystallization (Commentary)
475	Disease/ Diagnostics
4	Expression
23	General Information
9	General Stability
65	Inhibitors
6	kcat/KM [mM/s]
3	Ki Value [mM]
165	KM Value [mM]
36	Localization
75	Metals/Ions
39	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
145	Organism
1	Oxidation Stability
27	Pathway
68	PDB ID
26	pH Optimum
11	pH Range
5	pI Value
7	Posttranslational Modification
74	Protein Variants
35	Purification (Commentary)
4	Reaction
1	Reaction Type
127	Reference
78	Source Tissue
18	Specific Activity [micromol/min/mg]
7	Storage Stability
212	Substrates and Products (Substrate)
47	Subunits
157	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
6	Temperature Stability [°C]
73	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 6.2.1.1 - acetate-CoA ligase

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetylation

5 entries

proteolytic modification

Mus musculus

Q99NB1

the putative mitochondrial targeting signal is cleaved during the transportation of the enzyme into the mitochondria matrix

652101

side-chain modification

Bacillus subtilis

-

the acetyltransferase enzyme, AcuA, controls the activity of the acetyl coenzyme A synthetase, AcsA, by acetylating residue Lys549, overview

692866

acetylation

Salmonella enterica

-

-

746272

acetylation

Salmonella enterica

-

posttranslational regulation by acetylation of Lys609. Acetylation blocks synthesis of the adenylate intermediate but does not affect the thioester-forming activity of the enzyme

653891

acetylation

Salmonella enterica

-

the enzyme is regulated by a Sir2-dependent protein acetylation/deacetylation system. Leu641 is critical for the acetylation of the enzyme by protein acetyltransferase.Mutation at Leu641 prevents the acetylation of Acs by protein acetyltransferase and maintains the acetyl-coenzyme A synthetase in its active state

662385

acetylation

Streptomyces lividans

-

-

745793

acetylation

Streptomyces lividans

-

the enzyme is poorly acetylated in vitro by the Streptomyces lividans protein acetyltransferase Pat

746272