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6.2.1.1: acetate-CoA ligase

This is an abbreviated version!
For detailed information about acetate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.1

Reaction

ATP
+
acetate
 +
CoA
=
AMP
 +
diphosphate
 +
acetyl-CoA

Synonyms

ACAS, ACD, AceCS, AceCS1, AceCS2, Acetate thiokinase, Acetate--CoA ligase, acetate:CoA ligase (AMP-forming), Acetic thiokinase, Acetyl activating enzyme, Acetyl CoA ligase, Acetyl CoA synthase, acetyl CoA synthetase, acetyl coenzyme A synthase/carbon monoxide dehydrogenase, Acetyl coenzyme A synthetase, Acetyl-CoA synthase, Acetyl-CoA synthetase, acetyl-CoA synthetase 2, acetyl-CoA synthetase short-chain family member 2, Acetyl-coenzyme A synthase, acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-coenzyme A synthetase, ACS, ACS/CODH, ACS1, Acs1p, ACS2, Acs2p, AcsA, acsA1, AcsA2, AcsA3, ACSS2, Acyl-activating enzyme, Acyl-CoA synthetase, adenosine monophosphate-forming acetyl-CoA synthetase, ADP-forming acetyl-CoA synthetase, AF-ACS2, AMP acetyl-coenzyme A synthetase, AMP-Acs, AMP-dependent ACS, AMP-forming acetyl coenzyme A synthetase, AMP-forming acetyl-CoA synthetase, AMP-forming ACS, AMP-forming CoA ligase, carbon monoxide dehydrogenase/acety-coenzyme A synthase, carbon monoxide dehydrogenase/acetyl-CoA synthase, CODH/ACS, More, MT-ACS1, mtCODH/ACS, Mthe_1194, SeAcs, Short chain fatty acyl-CoA synthetase, Short-chain acyl-coenzyme A synthetase, Synthetase, acetyl coenzyme A

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.1 acetate-CoA ligase

pH Range

pH Range on EC 6.2.1.1 - acetate-CoA ligase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 9
-
isoform ACS1 shows high levels of activity in a pH range of 7.0-8.0. Isoform ACS2 shows high levels of activity in a pH range of 7.5-8.5. Little activity is detected for either isoform ACS1 or ACS2 at pH levels below 5.0 or above 9.0
5.5 - 8.5
-
pH 5.5: about 60% of maximal activity, pH 8.5: about 50% of maximal activity
6 - 10.5
-
6: about 50% of maximal activity, 10.5: about 60% of activity maximum
6 - 9.7
-
6.0: about 45% of maximal activity, 9.7: about 70% of maximal activity
6.5 - 8.5
-
30-40% of maximal activity at pH 6.5 and 8.5
6.8 - 10.1
-
about 50% of maximal activity at pH 6.8 and pH 10.1
6.8 - 8.8
-
about 50% of maximal activity at pH 6.8 and 8.8
7.3 - 8.1
-
90% of maximal activity at pH 7.3 and 8.1
7.5 - 10
-
7.5: about 50% of maximal activity, 10.0: about 70% of maximal activity