6.2.1.1: acetate-CoA ligase
This is an abbreviated version!
For detailed information about acetate-CoA ligase, go to the full flat file.
Word Map on EC 6.2.1.1
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6.2.1.1
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synthetases
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peroxisomal
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palmitate
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acyltransferase
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cholesterol
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phospholipid
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triglyceride
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beta-oxidation
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citrate
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arachidonic
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carnitine
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medium-chain
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triacylglycerols
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triacsin
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palmitoyl-coa
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oleic
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lipogenesis
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glyoxylate
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6.2.1.3
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oleate
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acsls
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hypolipidemic
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codhs
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acetogenic
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propionyl-coa
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fadd
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phosphotransacetylase
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wood-ljungdahl
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atp-citrate
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oleoyl-coa
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glucose-limited
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arachnoid
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sn-glycerol-3-phosphate
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coash
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moorella
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1-14cacetate
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corrinoid
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fatps
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thermoaceticum
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arachidonoyl-coa
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acetoacetyl-coa
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very-long-chain
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adrenoleukodystrophy
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reacylation
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vlcfas
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extradural
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butyryl-coa
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alpha2beta2
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myristoyl-coa
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acaca
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medicine
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analysis
- 6.2.1.1
- synthetases
- peroxisomal
- palmitate
- acyltransferase
- cholesterol
- phospholipid
- triglyceride
-
beta-oxidation
- citrate
-
arachidonic
- carnitine
-
medium-chain
- triacylglycerols
- triacsin
- palmitoyl-coa
-
oleic
-
lipogenesis
- glyoxylate
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6.2.1.3
- oleate
-
acsls
-
hypolipidemic
-
codhs
-
acetogenic
- propionyl-coa
- fadd
- phosphotransacetylase
-
wood-ljungdahl
-
atp-citrate
- oleoyl-coa
-
glucose-limited
-
arachnoid
- sn-glycerol-3-phosphate
- coash
-
moorella
-
1-14cacetate
- corrinoid
-
fatps
- thermoaceticum
- arachidonoyl-coa
- acetoacetyl-coa
-
very-long-chain
- adrenoleukodystrophy
-
reacylation
-
vlcfas
-
extradural
- butyryl-coa
-
alpha2beta2
- myristoyl-coa
- acaca
- medicine
- analysis
Reaction
Synonyms
ACAS, ACD, AceCS, AceCS1, AceCS2, Acetate thiokinase, Acetate--CoA ligase, acetate:CoA ligase (AMP-forming), Acetic thiokinase, Acetyl activating enzyme, Acetyl CoA ligase, Acetyl CoA synthase, acetyl CoA synthetase, acetyl coenzyme A synthase/carbon monoxide dehydrogenase, Acetyl coenzyme A synthetase, Acetyl-CoA synthase, Acetyl-CoA synthetase, acetyl-CoA synthetase 2, acetyl-CoA synthetase short-chain family member 2, Acetyl-coenzyme A synthase, acetyl-coenzyme A synthase/carbon monoxide dehydrogenase, acetyl-coenzyme A synthetase, ACS, ACS/CODH, ACS1, Acs1p, ACS2, Acs2p, AcsA, acsA1, AcsA2, AcsA3, ACSS2, Acyl-activating enzyme, Acyl-CoA synthetase, adenosine monophosphate-forming acetyl-CoA synthetase, ADP-forming acetyl-CoA synthetase, AF-ACS2, AMP acetyl-coenzyme A synthetase, AMP-Acs, AMP-dependent ACS, AMP-forming acetyl coenzyme A synthetase, AMP-forming acetyl-CoA synthetase, AMP-forming ACS, AMP-forming CoA ligase, carbon monoxide dehydrogenase/acety-coenzyme A synthase, carbon monoxide dehydrogenase/acetyl-CoA synthase, CODH/ACS, More, MT-ACS1, mtCODH/ACS, Mthe_1194, SeAcs, Short chain fatty acyl-CoA synthetase, Short-chain acyl-coenzyme A synthetase, Synthetase, acetyl coenzyme A
ECTree
6.2.1.1 acetate-CoA ligaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.2.1.1 - acetate-CoA ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CheY + acetyl-CoA + ATP
acetyl-CheY + CoA + AMP + diphosphate
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CheY is the the excitatory response regulator in the chemotaxis system of Escherichia coli, acetyl-CoA synthetase-catalyzed transfer of acetyl groups from acetate to CheY and autocatalyzed transfer from AcCoA, mechanism, overview
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-
?
dATP + acetate + CoA
dAMP + diphosphate + acetyl-CoA
AceCS2 plays a role in the production of energy under ketogenic conditions, such as starvation and diabetes. Acetyl-CoAs produced by AceCS2 are utilized mainly for oxidation
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?
ATP + acetate + CoA
?
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enzyme plays an important role in the oxidative part of the aceticlastic reaction
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-
?
ATP + acetate + CoA
?
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enzyme form Acs1p is primarily responsible for acetate activation during gluconeogenic growth. Enzyme form Acs2p is likely to be the major producer of cytosolic acetyl-CoA
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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gene acs encoding the enzyme is regulated by quorum sensing, and acs regulation plays a role in symbiosis, overview
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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acetate-CoA ligase is a key enzyme for conversion of acetate to acetyl-CoA
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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enzyme is involved in pathway of acetate activation. Cells induce acs transcription, and thus the ability to assimilate acetate, in response to rising cAMP levels, falling oxygen partial pressure, and the flux of carbon through pathways associated with acetate metabolism
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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-
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
the enzyme activates acetate so that it can be used for lipid synthesis or for energy generation. The acetyl-CoA synthetase mRNA, and hence the ability of cells to activate acetate, is regulated by sterol regulatory element-binding proteins in parallel with fatty acid synthesis in animal cells
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
AceCS2 is reversibly acetylated at Lys642 in the active site of the enzyme. A mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
acetate-CoA ligase is a key enzyme for conversion of acetate to acetyl-CoA
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activation of acetate in energy metabolism
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activation of acetate in energy metabolism
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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the bifunctional enzyme carbon monoxide dehydrogenase/acetyl-coenzyme A synthase is a key enzyme in the Wood-Ljungdahl pathway of carbon fixation
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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reaction of acetylated ACS with CoA and Fd-II, a step of the catalytic cycle in which the acetylated ACS reacts with CoA to form acetyl-CoA
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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lipogenic enzyme, gene is highly induced by SREBP-1a, SREBP-1c and SREBP-2. The enzyme might also play an important role in basic cellular energy metabolism
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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-
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
acetyl-CoA synthetase from Pseudomonas putida U is the only acyl-CoA activating enzyme induced by acetate in this bacterium
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-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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-
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?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
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-
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?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
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aerobic taurine dissimilation via acetate kinase and acetate-CoA ligase. Acetate-CoA ligase operates at the end of the pathway
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-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
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aerobic taurine dissimilation via acetate kinase and acetate-CoA ligase. Acetate-CoA ligase operates at the end of the pathway
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-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
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nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Acs2p is the major acetyl-CoA source for HATs in glucose
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-
?
additional information
?
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metabolic connection between acetate utilization and cell density
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-
?
additional information
?
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role of ACS in destroying fermentative intermediates
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-
?
additional information
?
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the enzyme can catalyze the activation to their CoA thioesters of some of the side-chain precursors required in Penicillium chrysogenum and Aspergillus nidulans for the production of several penicillins
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-
?
additional information
?
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the acetyltransferase enzyme, AcuA, controls the activity of the acetyl coenzyme A synthetase, AcsA, by acetylating residue Lys549, overview
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-
?
additional information
?
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acetate thiokinase is not involved in autotrophic CO2 fixation
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-
?
additional information
?
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CODH/ACS is a bifunctional enzyme that is responsible for the reduction of CO2 to CO and subsequent assembly of acetyl-CoA, as part of the Wood-Ljungdahl carbon fixation pathway, the enzyme is a key player in the global carbon cycle
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-
?
additional information
?
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the enzyme can catalyze the activation to their CoA thioesters of some of the side-chain precursors required in Penicillium chrysogenum and Aspergillus nidulans for the production of several penicillins
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-
?
additional information
?
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may contribute to the adenosine 5'-tetraphosphate synthesis and adenosine 5'-pentaphosphate synthesis during yeast sporulation
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-
?
