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5.4.99.16: maltose alpha-D-glucosyltransferase

This is an abbreviated version!
For detailed information about maltose alpha-D-glucosyltransferase, go to the full flat file.

Word Map on EC 5.4.99.16

Reaction

maltose
=
alpha,alpha-trehalose

Synonyms

57-KDa trehalose synthase (Saccharomyces cerevisiae), Dgeo_0537, DKY63_02445, DOT40_01605, DrTreS, DrTS, DR_2036, FM102_08285, HMPREF9086_3732, Maltose alpha-D-glucosylmutase, Maltose alpha-D-glucosyltransferase, Maltose glucosylmutase, MTase, MtTS, Protein (Saccharomyces cerevisiae clone pMB14 gene CIF reduced), Protein (Saccharomyces cerevisiae gene CIF1 reduced), PTO0069, PTTS, Synthase, trehalose, Synthase, trehalose (Pimelobacter strain R48 clone pBRM8 gene treS precursor reduced), Synthase, trehalose (Saccharomyces cerevisiae gene TPS1 subunit), Synthase, trehalose (Saccharomyces cerevisiae gene TSL1 subunit), Synthase, trehalose (Thermus aquaticus strain ATCC33923 clone pBTM5), TaTS, Tfu_0584, Trehalose synthase, Trehalose synthase (Pimelobacter strain R48 clone pBRM8 gene treS precursor reduced), Trehalose synthetase, TreS, treSB, TSase, Tter_0330, TtTreS, TtTS

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.16 maltose alpha-D-glucosyltransferase

Inhibitors

Inhibitors on EC 5.4.99.16 - maltose alpha-D-glucosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-fluoro-alpha-D-glucosyl fluoride
-
behaves like a reversible inhibitor
acarbose
competitively inhibited by the potent alpha-glucosidase inhibitor acarbose, acarbose-binding site structure, overview
beta-mercaptoethanol
complete inhibition at 1 mM
Cd2+
-
slight inhibition
D-gluconohydroximino-1,5-lactam
-
-
D-glucose
in the presence of 10 mM D-glucose, TreS shows a 3.6fold increase in Km and a nearly unchanged Vmax for maltose, implying that D-glucose is a competitive inhibitor of TreS
deoxynojirimycin
-
-
dithiothreitol
9% inhibition at 5 mM, 12% at 10 mM
Fe3+
1 mM, 60% residual activity
Guanidine-HCl
-
complete inhibition at 1 M, 51% inhibition of aggregated enzyme
Na+
90% residual activity at 1 mM
sodium dodecylsulfate
-
1 mM, complete inhibition
sucrose
-
competitive inhibition of the interconversion between maltose and trehalose
Urea
-
90% inhibition at 2 M, 1% inhibition of aggregated enzyme
validoxylamine
xylodeoxynojirimycin
-
-
additional information
-