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5.3.99.4: prostaglandin-I synthase

This is an abbreviated version!
For detailed information about prostaglandin-I synthase, go to the full flat file.

Word Map on EC 5.3.99.4

Reaction

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
=
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate

Synonyms

Aortic cytochrom P450, CYP8A1, PGI synthase, PGI2 synthase, PGI2 synthetase, PGI2-S, PGIS, prostacyclin synthase, Prostacyclin synthetase, prostacyclin-synthase, prostacyclin/PGI2 synthase, Prostacycline synthetase, prostaglandin I synthase, Prostaglandin I2 synthase, Prostaglandin I2 synthetase, Ptgis, Synthetase, prostacyclin

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.4 prostaglandin-I synthase

Activating Compound

Activating Compound on EC 5.3.99.4 - prostaglandin-I synthase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
13-cis-retinoic acid
-
induces prostaglandin-I synthase activity and expression of mRNA and protein, mediated by retinoic acid receptor. Actinomycin and cycloheximide both inhibit the retinoic acid-induced expression. 13-cis-Retinoic acid additionally increases the release of prostaglandin I2, both spontaneous and thrombin-induced. Co-incubation with 13-cis-retinoic acid and interleukin-1beta results in a synergic increase in the release of prostaglandin I2
dithiothreitol
-
increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM
High density lipoprotein cholesterol
-
1.0 mg/ml stimulates 21%. Lower concentrations inhibit, 16% inhibition by 0.25 mg/ml
-
interleukin-1
-
-
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interleukin-6
-
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Low density lipoprotein cholesterol
-
0.5 mg/ml stimulates 27%. Inhibition at higher concentrations
-
NO
-
activation at moderate concentration, inhibition at high concentrations. Hemoglobin prevents both, activation and inhibition
reduced glutathione
-
increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM
TNFalpha
-
-
-
additional information
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