5.3.99.4: prostaglandin-I synthase
This is an abbreviated version!
For detailed information about prostaglandin-I synthase, go to the full flat file.
Word Map on EC 5.3.99.4
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5.3.99.4
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thromboxane
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cyclooxygenase
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endothelial
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arachidonic
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artery
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platelet
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cox-2
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vasodilator
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hypertension
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prostanoids
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endoperoxide
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eicosanoids
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pulmonary
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vessel
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indomethacin
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aorta
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6-keto-pgf1
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tranylcypromine
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peroxynitrite
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vasoconstriction
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endothelium-dependent
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6-keto-prostaglandin
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6-keto-pgf1alpha
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phosphoglucose
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iloprost
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tx
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mpges-1
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medicine
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6-keto
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antithrombotic
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5-lipoxygenase
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dazoxiben
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heme-thiolate
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ptges
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f1alpha
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synthase-1
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beraprost
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15-hpete
- 5.3.99.4
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thromboxane
-
cyclooxygenase
- endothelial
-
arachidonic
- artery
- platelet
- cox-2
-
vasodilator
- hypertension
-
prostanoids
-
endoperoxide
-
eicosanoids
- pulmonary
- vessel
- indomethacin
- aorta
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6-keto-pgf1
- tranylcypromine
- peroxynitrite
-
vasoconstriction
-
endothelium-dependent
-
6-keto-prostaglandin
-
6-keto-pgf1alpha
-
phosphoglucose
-
iloprost
- tx
- mpges-1
- medicine
-
6-keto
-
antithrombotic
-
5-lipoxygenase
- dazoxiben
-
heme-thiolate
- ptges
- f1alpha
- synthase-1
-
beraprost
- 15-hpete
Reaction
Synonyms
Aortic cytochrom P450, CYP8A1, PGI synthase, PGI2 synthase, PGI2 synthetase, PGI2-S, PGIS, prostacyclin synthase, Prostacyclin synthetase, prostacyclin-synthase, prostacyclin/PGI2 synthase, Prostacycline synthetase, prostaglandin I synthase, Prostaglandin I2 synthase, Prostaglandin I2 synthetase, Ptgis, Synthetase, prostacyclin
ECTree
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Substrates Products
Substrates Products on EC 5.3.99.4 - prostaglandin-I synthase
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REACTION DIAGRAM
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-6,9alpha-epoxy-11a,15-dihydroxyprosta-5,13-dienoate
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i.e. prostaglandin H2
prostaglandin I2
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
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-
-
-
?
10-hydroperoxyoctadeca-8,12-dienoic acid
10-oxooctadeca-8,12-dienoic acid + 10-oxodec-8-enoic acid + 10-hydroxyoctadeca-8,12-dienoic acid
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-
-
-
?
15-hydroperoxyeicosatetraenoic acid
13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid + 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid
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13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid and 15-ketoeicosatetraenoic acid result from homolytic cleavage of the O-O bond, whereas 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid results from heterolytic cleavage. About 80% of substrate is cleaved homolytically, and maximal velocity of homolytic cleavage is about 1.4fold faster than heterolytic cleavage
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?
prostaglandin H1
12-hydroxy-8,10-heptadecadienoic acid + malondialdehyde
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-
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?
additional information
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fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, is able to convert arachidonic acid to prostaglandin G2, prostaglandin H2 and prostaglandin I2. Fusion protein may directly synthesize prostaglandin I2 from arachidonic acid with Km value of 0.0032 mM
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-
?
prostaglandin G2
prostaglandin I2 + 15-hydroperoxyprostacyclin
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15-hydroperoxyprostacyclin decomposes to 6,15-diketo-prostaglandin F1alpha
?
?
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formation of prostaglandin I2, which is a powerful vasodilator and the most potent natural occuring inhibitor of platelet aggregation
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-
?
Prostaglandin H2
?
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produces prostaglandin I2 which has opposite actions on platelet aggregatory and vasoconstrictive properties
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-
?
Prostaglandin H2
?
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formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
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-
?
Prostaglandin H2
?
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formation of prostaglandin I2 which is a powerful vasodilator and the most potent naturally occuring inhibitor of platlet aggregation. An imbalance in the ratio of prostaglandin I2 to thromboxane A2, a compound that has opposite biological properties may reflect some of the changes occuring in various pathological situations including thrombosis and ischemia
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-
?
Prostaglandin H2
Prostaglandin I2
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prostaglandin I2 is readily hydrolyzed to 6-keto-prostaglandin F1alpha
?
Prostaglandin H2
Prostaglandin I2
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-
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-
?
Prostaglandin H2
Prostaglandin I2
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in vivo, this reaction is coupled to a previous one, where arachidonic acid is converted by cyclooxygenase and yields the substrate PGH2
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-
?
Prostaglandin H2
Prostaglandin I2
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prostaglandin I2 is readily hydrolyzed to 6-keto-prostaglandin F1alpha
?