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5.3.99.4: prostaglandin-I synthase

This is an abbreviated version!
For detailed information about prostaglandin-I synthase, go to the full flat file.

Word Map on EC 5.3.99.4

Reaction

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
=
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate

Synonyms

Aortic cytochrom P450, CYP8A1, PGI synthase, PGI2 synthase, PGI2 synthetase, PGI2-S, PGIS, prostacyclin synthase, Prostacyclin synthetase, prostacyclin-synthase, prostacyclin/PGI2 synthase, Prostacycline synthetase, prostaglandin I synthase, Prostaglandin I2 synthase, Prostaglandin I2 synthetase, Ptgis, Synthetase, prostacyclin

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.4 prostaglandin-I synthase

Expression

Expression on EC 5.3.99.4 - prostaglandin-I synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples
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after 16 weeks the prostacyclin synthase mRNA levels are reduced
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after 8 weeks on fat diet, aortic arches from low-density lipoprotein receptor deficient, LDL r-KO, mice shows a significant increase in prostacyclin synthase levels
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angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta
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enzyme expression, in terms of mRNA and protein, are lower in tumour samples than in non-tumoural mucosa
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for overexpression of prostacyclin synthase transgenic mice, carrying the rat prostacyclin synthase gene, are developed
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hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity
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interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression
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PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue
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the enzyme expression is downregulated in several types of cancer
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the enzyme has enhanced expression mainly in endothelial cells of patients with immunglobulin A nephropathy
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