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Literature summary for 5.3.99.4 extracted from

  • McNamara, D.B.; Hussey, J.L.; Kerstein, M.D.; Rosenson, R.S.; Hyman, A.L.; Kadowitz, P.J.
    Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes (1984), Biochem. Biophys. Res. Commun., 118, 33-39.
    View publication on PubMed
Search for more literature for 5.3.99.4

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM Bos taurus
reduced glutathione increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
tranylcypromine 10 mM, 90% inhibition in absence or presence of 2 mM reduced glutathione Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Bos taurus
-
-
microsome
-
 Ovis aries
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Ovis aries
-
 ram
-

Oxidation Stability

Oxidation Stability Organism
the prostacyclin synthase is unusually sensitive to the redox state or sulfhydryl oxidation of the enzyme Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
coronary artery
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Homo sapiens Prostaglandin I2 prostaglandin I2 ?
Prostaglandin H2
-
 Bos taurus Prostaglandin I2 prostaglandin I2 ?
Prostaglandin H2
-
 Ovis aries Prostaglandin I2 prostaglandin I2 ?
Prostaglandin H2
-
 Canis lupus familiaris Prostaglandin I2 prostaglandin I2 ?