5.3.99.4: prostaglandin-I synthase

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For detailed information about prostaglandin-I synthase, go to the full flat file.

Word Map on EC 5.3.99.4

5.3.99.4

thromboxane

cyclooxygenase

endothelial

arachidonic

artery

platelet

cox-2

vasodilator

hypertension

prostanoids

endoperoxide

eicosanoids

pulmonary

vessel

indomethacin

aorta

6-keto-pgf1

tranylcypromine

peroxynitrite

vasoconstriction

endothelium-dependent

6-keto-prostaglandin

6-keto-pgf1alpha

phosphoglucose

iloprost

tx

mpges-1

medicine

6-keto

antithrombotic

5-lipoxygenase

dazoxiben

heme-thiolate

ptges

f1alpha

synthase-1

beraprost

15-hpete

Reaction

(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate

(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate

Synonyms

Aortic cytochrom P450, CYP8A1, PGI synthase, PGI2 synthase, PGI2 synthetase, PGI2-S, PGIS, prostacyclin synthase, Prostacyclin synthetase, prostacyclin-synthase, prostacyclin/PGI2 synthase, Prostacycline synthetase, prostaglandin I synthase, Prostaglandin I2 synthase, Prostaglandin I2 synthetase, Ptgis, Synthetase, prostacyclin

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.99 Other intramolecular oxidoreductases

5.3.99.4 prostaglandin-I synthase

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Results	in table
11	Activating Compound
748	AA Sequence
19	Application
1	CAS Registry Number
21	Cloned(Commentary)
18	Cofactor
2	Crystallization (Commentary)
683	Disease/ Diagnostics
11	Expression
5	General Information
1	General Stability
2	IC50 Value
53	Inhibitors
7	KM Value [mM]
35	Localization
26	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
79	Organism
3	Oxidation Stability
7	Pathway
8	PDB ID
2	pH Optimum
1	Posttranslational Modification
5	Protein Variants
15	Purification (Commentary)
9	Reaction
20	Reaction Type
79	Reference
90	Source Tissue
13	Specific Activity [micromol/min/mg]
2	Storage Stability
84	Substrates and Products (Substrate)
13	Subunits
75	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Organic Solvent Stability

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Organic Solvent Stability on EC 5.3.99.4 - prostaglandin-I synthase

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Triton X-100

Homo sapiens

within 30 s, about 75% of PGH2 is presented to the PGIS active side and isomerized to PGI2 by the membrane-bound PGIS. In contrast, only about 20% of the substrate is isomerized to the product by the detergent-solubilized (Triton X-100) PGIS. Replacement of the membrane with detergent does not alter the PGIS active side conformation, but affects the substrate presentation

660808