Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1 | - |
Homo sapiens | |
interleukin-6 | - |
Homo sapiens | |
TNFalpha | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | prostacyclin synthase may be chemopreventive in cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rofecoxib | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
nuclear membrane | - |
Homo sapiens | 31965 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung cancer cell | - |
Homo sapiens | - |
myometrial cell | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
smooth muscle cell | - |
Homo sapiens | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
vascular endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prostacyclin synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples | down |
Homo sapiens | PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue | up |