5.3.99.4: prostaglandin-I synthase
This is an abbreviated version!
For detailed information about prostaglandin-I synthase, go to the full flat file.
Word Map on EC 5.3.99.4
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5.3.99.4
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thromboxane
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cyclooxygenase
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endothelial
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arachidonic
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artery
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platelet
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cox-2
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vasodilator
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hypertension
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prostanoids
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endoperoxide
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eicosanoids
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pulmonary
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vessel
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indomethacin
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aorta
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6-keto-pgf1
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tranylcypromine
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peroxynitrite
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vasoconstriction
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endothelium-dependent
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6-keto-prostaglandin
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6-keto-pgf1alpha
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phosphoglucose
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iloprost
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tx
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mpges-1
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medicine
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6-keto
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antithrombotic
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5-lipoxygenase
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dazoxiben
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heme-thiolate
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ptges
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f1alpha
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synthase-1
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beraprost
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15-hpete
- 5.3.99.4
-
thromboxane
-
cyclooxygenase
- endothelial
-
arachidonic
- artery
- platelet
- cox-2
-
vasodilator
- hypertension
-
prostanoids
-
endoperoxide
-
eicosanoids
- pulmonary
- vessel
- indomethacin
- aorta
-
6-keto-pgf1
- tranylcypromine
- peroxynitrite
-
vasoconstriction
-
endothelium-dependent
-
6-keto-prostaglandin
-
6-keto-pgf1alpha
-
phosphoglucose
-
iloprost
- tx
- mpges-1
- medicine
-
6-keto
-
antithrombotic
-
5-lipoxygenase
- dazoxiben
-
heme-thiolate
- ptges
- f1alpha
- synthase-1
-
beraprost
- 15-hpete
Reaction
Synonyms
Aortic cytochrom P450, CYP8A1, PGI synthase, PGI2 synthase, PGI2 synthetase, PGI2-S, PGIS, prostacyclin synthase, Prostacyclin synthetase, prostacyclin-synthase, prostacyclin/PGI2 synthase, Prostacycline synthetase, prostaglandin I synthase, Prostaglandin I2 synthase, Prostaglandin I2 synthetase, Ptgis, Synthetase, prostacyclin
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General Information
General Information on EC 5.3.99.4 - prostaglandin-I synthase
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malfunction
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enzyme variant rs5602 is associated with a risk of spontaneous abortion
physiological function
additional information
PGIS over-expressed mesenchymal stem cells are more resistant to free radical stress-induced apoptosis, secrete paracrine factors to enhance immunemodulation and, thus, provide cardiac protection
physiological function
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the enzyme is critical for the regulation of platelet aggregation and vascular tone
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structure-function relationship analysis by a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches using prostaglandin H2 analogues U46619 or (Z)-7-[(1S,4R,5R,6S)-5-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid, U51605 or 9alpha,11alpha-azoprosta-5Z,13E-dien-1-oic acid, and U44069 or (Z)-7-[(1R,4S,5R,6S)-6-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid and inhibitors minoxidil, clotrimazole, miconazole, overview
additional information
-
structure-function relationship analysis by a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches using prostaglandin H2 analogues U46619 or (Z)-7-[(1S,4R,5R,6S)-5-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acid, U51605 or 9alpha,11alpha-azoprosta-5Z,13E-dien-1-oic acid, and U44069 or (Z)-7-[(1R,4S,5R,6S)-6-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxabicyclo[2.2.1]heptan-5-yl]hept-5-enoic acid and inhibitors minoxidil, clotrimazole, miconazole, overview