4.2.1.22: cystathionine beta-synthase

This is an abbreviated version!
For detailed information about cystathionine beta-synthase, go to the full flat file.

Word Map on EC 4.2.1.22

4.2.1.22

h2s

sulfide

homocystinuria

hyperhomocysteinemia

artery

spacer

corticobasal

candida

mthfr

carotid

folate

transsulfuration

conidia

cajal

nahs

dextrose

methylenetetrahydrofolate

bismuth

hallucinations

anamorphic

palsy

supranuclear

charles

remethylation

reisolated

conidiophore

gamma-lyase

biodiversity

hyaline

chemoreceptor

gasotransmitter

3-mercaptopyruvate

frontotemporal

sulfurtransferase

thromboembolic

ascospore

rinsed

aminooxyacetic

apraxia

snrnps

symptomless

hydrosulfide

marxianus

visuospatial

5,10-methylenetetrahydrofolate

voxel-based

appressoria

naocl

medicine

diagnostics

ascus

phytopathological

analysis

Reaction

L-serine

+

L-homocysteine

=

L-cystathionine

+

H2O

Synonyms

Beta-thionase, CBS, CBS424, CDCP2, CNNM2, Cys4, CysB, cystathionine beta synthase, cystathionine beta-synthase, cystathionine beta-synthase domain-containing protein, cystathionine-beta-synthase, Cysteine synthase, EC 4.2.1.21, hCBS, Hemoprotein H-450, LbrM.17.0230, Methylcysteine synthase, osmoprotectant transporter OpuC, PF1953, PH0267, Serine sulfhydrase, Serine sulfhydrylase, Serine sulphhydrase, TA0289, TM0935, TV1335, yCBS, ytCBS

ECTree

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.22 cystathionine beta-synthase

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Results	in table
51	Activating Compound
8374	AA Sequence
15	Application
1	CAS Registry Number
54	Cloned(Commentary)
121	Cofactor
18	Crystallization (Commentary)
6623	Disease/ Diagnostics
10	Expression
36	General Information
10	General Stability
3	IC50 Value
72	Inhibitors
46	kcat/KM [mM/s]
11	Ki Value [mM]
142	KM Value [mM]
7	Localization
16	Metals/Ions
42	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
196	Organism
10	Pathway
121	PDB ID
29	pH Optimum
8	pH Range
3	Posttranslational Modification
199	Protein Variants
42	Purification (Commentary)
14	Reaction
2	Reaction Type
196	Reference
89	Source Tissue
38	Specific Activity [micromol/min/mg]
6	Storage Stability
263	Substrates and Products (Substrate)
48	Subunits
109	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
6	Temperature Stability [°C]
90	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 4.2.1.22 - cystathionine beta-synthase

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100000

Rattus norvegicus

-

aged enzyme extract, gel filtration

115000

Rattus norvegicus

-

aged enzyme extract, gel filtration

119000

Trichostrongylus colubriformis

-

fresh enzyme extract, gel filtration

1330000

-

multimer, gel filtration

19700

Thermoplasma volcanium

-

2 * 19700, calculated from sequence

20200

Pyrococcus furiosus

-

3 * 20200, calculated from sequence

20300

Thermoplasma acidophilum

-

2 * 20300, calculated from sequence

235000

show

250000

show

288000

Nippostrongylus brasiliensis

-

fresh and aged enzyme extract, gel filtration

290000

Rattus norvegicus

-

fresh enzyme extract, gel filtration

36800

Thermoplasma volcanium

-

gel filtration

38000

Thermoplasma acidophilum

-

gel filtration

400000

Saccharomyces cerevisiae

-

gel filtration, truncated enzyme, octamer

45000

show

48000

show

486000

-

octamer, gel filtration

50000 - 130000

-

existence in multiple molecular forms of MW 50000-130000, 235000, 500000, gel filtration

500000

-

existence in multiple molecular forms of MW 50000-130000, 235000, 500000, gel filtration

55000

show

61000

-

4 * 61000

62800

Pyrococcus furiosus

-

gel filtration

63000

show

65000

-

x * 65000, SDS-PAGE

68000

show

70000

Saccharomyces cerevisiae

-

gel filtration, truncated enzyme, dimer

94000

-

gel filtration

additional information

-

high tendency for aggregation

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Release 2023.1 (January 2023)