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4.2.1.22: cystathionine beta-synthase

This is an abbreviated version!
For detailed information about cystathionine beta-synthase, go to the full flat file.

Word Map on EC 4.2.1.22

Reaction

L-serine
+
L-homocysteine
=
L-cystathionine
 +
H2O

Synonyms

Beta-thionase, CBS, CBS424, CDCP2, CNNM2, Cys4, CysB, cystathionine beta synthase, cystathionine beta-synthase, cystathionine beta-synthase domain-containing protein, cystathionine-beta-synthase, Cysteine synthase, EC 4.2.1.21, hCBS, Hemoprotein H-450, LbrM.17.0230, Methylcysteine synthase, osmoprotectant transporter OpuC, PF1953, PH0267, Serine sulfhydrase, Serine sulfhydrylase, Serine sulphhydrase, TA0289, TM0935, TV1335, yCBS, ytCBS

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.22 cystathionine beta-synthase

Expression

Expression on EC 4.2.1.22 - cystathionine beta-synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
butyrate significantly increases CBS protein expression, butyrate-stimulated CBS expression is not changed by trichostatin A
-
decreased expression after exogenous addition alltrans-retinoic acid
-
expression is elevated in the latter half of logarithmic growth phase
expression level of CBS in 120 hepatocellular carcinoma specimens evaluated by RT-PCR is markedly lower than in surrounding non-cancerous liver. Reduced CBS expression is significantly correlated with high tumor stage. A survival analysis shows that a significantly shorter overall survival time is observed in patients with reduced CBS expression
-
in hemizygous (+/-) CBS knockout mice the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA
-
mice at the unusual age of 28 months even have a higher hippocampal enzyme expression than young mice
-
protein level and activity increase with incubation time, upon stimulation, and similar to intracellular homocysteine, depending on intra- and extracellular homocysteine and glutathione concentrations
-
stage-specific increase in the levels of protein expression and activity under in vitro stress conditions induced by hydrogen peroxide, S-nitroso-N-acetylpenicillamine, or antimonial compounds
the enzyme is overexpressed in primary epithelial ovarian cancer and ovarian cancer cell lines
-
treatment with homocysteine upregulates cystathionine gamma lyase CSE but downregulates CBS whereas Na2S or H2S-donoer GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner. In the homocysteine-treated cardiomyocytes, CBS and miR-133a are downregulated and hypertrophy is induced
-