Reference on EC 4.2.1.22 - cystathionine beta-synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Braunstein, A.E.; Goryachenkova, E.V.
The beta-replacement-specific pyridoxal-P-dependent lyases
Adv. Enzymol. Relat. Areas Mol. Biol.
56
1-89
1984
Gallus gallus, Homo sapiens, Rattus norvegicus
Skovby, F.; Kraus, J.P.; Rosenberg, L.E.
Biosynthesis and proteolytic activation of cystathionine beta-synthase in rat liver
J. Biol. Chem.
25
588-593
1984
Rattus norvegicus
Kraus, J.P.; Rosenberg, L.E.
Cystathionine beta-synthase from human liver: improved purification scheme and additional characterization of the enzyme in crude and pure form
Arch. Biochem. Biophys.
222
44-52
1983
Homo sapiens
Kraus, J.; Packman, S.; Fowler, B.; Rosenberg, L.E.
Purification and properties of cystathionine beta-synthase from human liver
J. Biol. Chem.
253
6523-6528
1978
Homo sapiens
Ansell, P.R.J.; Tudball, N.
The existence of human liver cystathionine beta-synthase in multiple molecular forms
Biochim. Biophys. Acta
483
443-451
1977
Homo sapiens
Suda, M.; Nakagawa, H.; Kimura, H.
Cystathionine synthase (rat liver)
Methods Enzymol.
17B
454-458
1971
Rattus norvegicus
-
Roper, M.D.; Kraus, J.P.
Rat cystathionine beta-synthase: expression of four alternatively spliced isoforms in transfected cultured cells
Arch. Biochem. Biophys.
298
514-521
1992
Rattus norvegicus
Tudball, N.; Reed, M.A.
Purification and properties of cystathionine synthase from human liver
Biochem. Biophys. Res. Commun.
67
550-555
1975
Homo sapiens
Porter, P.N.; Grishaver, M.S.; Jones, O.W.
Characterization of human cystathionine beta-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase
Biochim. Biophys. Acta
364
128-139
1974
Homo sapiens
Pieniazek, N.J.; Stepien, P.P.; Paszewski, A.
An Aspergillus nidulans mutant lacking cystathionine beta-synthase: identity of L-serine sulfhydrolase with cystathionine beta-synthase and its distinctness from O-acetyl-L-serine sulfhydrolase
Biochim. Biophys. Acta
297
37-47
1973
Aspergillus nidulans
Braunstein, A.E.; Goryachenkova, E.V.; Tolosa, E.A.; Willhardt, I.H.; Yefremova, L.L.
Specificity and some other properties of liver serine sulphhydrolase: evidence for its identity with cystathionine beta-synthase
Biochim. Biophys. Acta
242
247-260
1971
Gallus gallus, Rattus norvegicus
Nakagawa, H.; Kimura, H.
Purification and properties of cystathionine synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase
Biochem. Biophys. Res. Commun.
32
208-214
1968
Rattus norvegicus
-
Schlossmann, K.; Brueggemann, J.; Lynen, F.
Biosynthese des Cysteins. I. Nachweis und Isolierung der Serinsulfhydrase aus Bckerhefe
Biochem. Z.
336
258-273
1962
Saccharomyces cerevisiae
-
Walker, J.; Barrett, J.
Biochemical characterization of the enzyme responsible for activated L-serine sulphydrase" activity in nematodes
Exp. Parasitol.
74
205-215
1992
Haemonchus contortus, Nippostrongylus brasiliensis, Steinernema bibionis, Trichostrongylus colubriformis
Walker, J.; Barrett, J.; Thong, K.W.
The identification of a variant form of cystathionine beta-synthase
Exp. Parasitol.
75
415-424
1992
Haemonchus contortus, Nippostrongylus brasiliensis, Panagrellus redivivus, Rattus norvegicus, Steinernema bibionis, Trichostrongylus colubriformis
Ono, B.I.; Kijima, K.; Inoue, T.; Miyoshi, A.I.; Matsuda, A.; Shinoda, S.
Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase
Yeast
10
333-339
1994
Saccharomyces cerevisiae
Bukovska, G.; Kery, V.; Kraus, J.P.
Expression of human cystathionine beta-synthase in Escherichia coli: purification and characterization
Protein Expr. Purif.
5
442-448
1994
Homo sapiens
Taoka, S.; Ohja, S.; Shan, X.; Kruger, W.D.; Banerjee, R.
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity
J. Biol. Chem.
273
25179-25184
1998
Homo sapiens
Kery, V.; Poneleit, L.; Meyer, J.D.; Manning, M.C.; Kraus, J.P.
Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase
Biochemistry
38
2716-2724
1999
Homo sapiens
Papadopoulos, A.I.; Walker, J.; Barrett, J.
A novel cystathionine beta-synthase from Panagrellus redivivus (Nematoda)
Int. J. Biochem. Cell Biol.
28
543-549
1996
Panagrellus redivivus
Kery, V.; Poneleit, L.; Kraus, J.P.
Trypsin cleavage of human cystathionine beta-synthase into an evolutionary conserved active core: structural and functional consequences
Arch. Biochem. Biophys.
355
222-232
1998
Homo sapiens
Gallagher, P.M.; Naughten, E.; Hanson, N.Q.; Schwichtenberg, K.; Bignell, M.; Yuan, M.; Ward, P.; Yap, S.; Whitehead, A.S.; Tsai, M.Y.
Characterization of mutations in the cystathionine beta-synthase gene in irish patients with homocystinuria
Mol. Genet. Metab.
65
298-302
1998
Homo sapiens
Janosik, M.; Meier, M.; Kery, V.; Oliveriusova, J.; Burkhard, P.; Kraus, J.P.
Crystallization and preliminary x-ray diffraction analysis of the active core of human recombinant cystathionine beta-synthase: an enzyme involved in vascular disease
Acta Crystallogr. Sect. D
D57
289-291
2001
Homo sapiens
Vadon-Le Goff, S.; Delaforge, M.; Boucher, J.L.; Janosik, M.; Kraus, J.P.; Mansuy, D.
Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes
Biochem. Biophys. Res. Commun.
283
487-492
2001
Homo sapiens, Rattus norvegicus
Taoka, S.; Widjaja, L.; Banerjee, R.
Assignment of enzymatic functions to specific regions of the PLP-dependent heme protein cystathionine beta-synthase
Biochemistry
38
13155-13161
1999
Homo sapiens
Taoka, S.; West, M.; Banerjee, R.
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites
Biochemistry
38
2738-2744
1999
Homo sapiens
Ojha, S.; Hwang, J.; Kabil, O.; Penner-Hahn, J.E.; Banerjee, R.
Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies
Biochemistry
39
10542-10547
2000
Homo sapiens
Jhee, K.H.; McPhie, P.; Miles, E.W.
Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation
Biochemistry
39
10548-10556
2000
Saccharomyces cerevisiae
Janosik, M.; Kery, V.; Gaustadnes, M.; Maclean, K.N.; Kraus, J.P.
Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region
Biochemistry
40
10625-10633
2001
Homo sapiens
Jhee, K.H.; Niks, D.; McPhie, P.; Dunn, M.F.; Miles, E.W.
The reaction of yeast cystathionine beta-synthase is rate-limited by the conversion of aminoacrylate to cystathionine
Biochemistry
40
10873-10880
2001
Saccharomyces cerevisiae
Taoka, S.; Lepore, B.W.; Kabil, O.; Ojha, S.; Ringe, D.; Banerjee, R.
Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme
Biochemistry
41
10454-10461
2002
Homo sapiens (P35520), Homo sapiens
Evande, R.; Blom, H.; Boers, G.H.; Banerjee, R.
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase
Biochemistry
41
11832-11837
2002
Homo sapiens
Jhee, K.H.; Niks, D.; McPhie, P.; Dunn, M.F.; Miles, E.W.
Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine
Biochemistry
41
1828-1835
2002
Saccharomyces cerevisiae
Ojha, S.; Wu, J.; LoBrutto, R.; Banerjee, R.
Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase
Biochemistry
41
4649-4654
2002
Homo sapiens
Aitken, S.M.; Kirsch, J.F.
Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction
Biochemistry
42
571-578
2003
Saccharomyces cerevisiae
Aitken, S.M.; Kirsch, J.F.
Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificity
Biochemistry
43
1963-1971
2004
Saccharomyces cerevisiae
Meier, M.; Oliveriusova, J.; Kraus, J.P.; Burkhard, P.
Structural insights into mutations of cystathionine beta-synthase
Biochim. Biophys. Acta
1647
206-213
2003
Homo sapiens
Banerjee, R.; Evande, R.; Kabil, O.; Ojha, S.; Taoka, S.
Reaction mechanism and regulation of cystathionine beta-synthase
Biochim. Biophys. Acta
1647
30-35
2003
Saccharomyces cerevisiae, Homo sapiens, Mammalia
Meier, M.; Janosik, M.; Kery, V.; Kraus, J.P.; Burkhard, P.
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein
EMBO J.
20
3910-3916
2001
Homo sapiens (P35520), Homo sapiens
Bruno, S.; Schiaretti, F.; Burkhard, P.; Kraus, J.P.; Janosik, M.; Mozzarelli, A.
Functional properties of the active core of human cystathionine beta-synthase crystals
J. Biol. Chem.
276
16-19
2001
Homo sapiens
Kabil, O.; Toaka, S.; LoBrutto, R.; Shoemaker, R.; Banerjee, R.
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme
J. Biol. Chem.
276
19350-19355
2001
Saccharomyces cerevisiae, Homo sapiens
Taoka, S.; Banerjee, R.
Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase
J. Biol. Chem.
277
22421-22425
2002
Saccharomyces cerevisiae
Eto, K.; Kimura, H.
A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase
J. Biol. Chem.
277
42680-42685
2002
Rattus norvegicus
Oliveriusova, J.; Kery, V.; Maclean, K.N.; Kraus, J.P.
Deletion mutagenesis of human cystathionine beta-synthase. Impact on activity, oligomeric status, and S-adenosylmethionine regulation
J. Biol. Chem.
277
48386-48394
2002
Homo sapiens
Zou, C.G.; Banerjee, R.
Tumor necrosis factor-a-induced targeted proteolysis of cystathionine beta-xynthase modulates redox homeostasis
J. Biol. Chem.
278
16802-16808
2003
Homo sapiens
Miles, E.W.; Kraus, J.P.
Cystathionine {beta}-synthase: structure, function, regulation and location of homocystinuria-causing mutations
J. Biol. Chem.
279
29871-29874
2004
Saccharomyces cerevisiae, Trypanosoma cruzi, Homo sapiens (P35520)
Maclean, K.N.; Janosik, M.; Oliveriusova, J.; Kery, V.; Kraus, J.P.
Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase
J. Inorg. Biochem.
81
161-171
2000
Saccharomyces cerevisiae (P32582), Saccharomyces cerevisiae
Taoka, S.; Banerjee, R.
Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme
J. Inorg. Biochem.
87
245-251
2001
Homo sapiens
Taoka, S.; Green, E.L.; Loehr, T.M.; Banerjee, R.
Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity
J. Inorg. Biochem.
87
253-259
2001
Homo sapiens
Shen, W.; McGath, M.K.; Evande, R.; Berkowitz, D.B.
A continuous spectrophotometric assay for human cystathionine beta-synthase
Anal. Biochem.
342
103-110
2005
Homo sapiens
Bar-Or, D.; Curtis, C.G.; Sullivan, A.; Rael, L.T.; Thomas, G.W.; Craun, M.; Bar-Or, R.; Maclean, K.N.; Kraus, J.P.
Plasma albumin cysteinylation is regulated by cystathionine beta-synthase
Biochem. Biophys. Res. Commun.
325
1449-1453
2004
Rattus norvegicus
Ichinohe, A.; Kanaumi, T.; Takashima, S.; Enokido, Y.; Nagai, Y.; Kimura, H.
Cystathionine beta-synthase is enriched in the brains of Down's patients
Biochem. Biophys. Res. Commun.
338
1547-1550
2005
Homo sapiens
Pazicni, S.; Lukat-Rodgers, G.S.; Oliveriusova, J.; Rees, K.A.; Parks, R.B.; Clark, R.W.; Rodgers, K.R.; Kraus, J.P.; Burstyn, J.N.
The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH
Biochemistry
43
14684-14695
2004
Homo sapiens
Wang, L.; Jhee, K.H.; Hua, X.; DiBello, P.M.; Jacobsen, D.W.; Kruger, W.D.
Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice
Circ. Res.
94
1318-1324
2004
Homo sapiens
Enokido, Y.; Suzuki, E.; Iwasawa, K.; Namekata, K.; Okazawa, H.; Kimura, H.
Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS
FASEB J.
19
1854-1856
2005
Mus musculus
Wang, L.; Chen, X.; Tang, B.; Hua, X.; Klein-Szanto, A.; Kruger, W.D.
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model
Hum. Mol. Genet.
14
2201-2208
2005
Homo sapiens
Chen, X.; Jhee, K.H.; Kruger, W.D.
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine
J. Biol. Chem.
279
52082-52086
2004
Homo sapiens
de Lucca, M.; Casique, L.
Characterization of cystathionine b-synthase gene mutations in homocystinuric Venezuelan patients: identification of one novel mutation in exon 6
Mol. Genet. Metab.
81
209-215
2004
Homo sapiens
Miller, M.D.; Schwarzenbacher, R.; et al.
Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution
Proteins
57
213-217
2004
Thermotoga maritima
Pong, W.W.; Stouracova, R.; Frank, N.; Kraus, J.P.; Eldred, W.D.
Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals
J. Comp. Neurol.
505
158-165
2007
Ambystoma tigrinum, Mus musculus
Vitvitsky, V.; Prudova, A.; Stabler, S.; Dayal, S.; Lentz, S.R.; Banerjee, R.
Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels
Am. J. Physiol. Renal Physiol.
293
F594-F600
2007
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Frank, N.; Kent, J.O.; Meier, M.; Kraus, J.P.
Purification and characterization of the wild type and truncated human cystathionine beta-synthase enzymes expressed in E. coli
Arch. Biochem. Biophys.
470
64-72
2007
Homo sapiens
Frank, N.; Kery, V.; Maclean, K.N.; Kraus, J.P.
Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding
Biochemistry
45
11021-11029
2006
Homo sapiens
Kabil, O.; Zhou, Y.; Banerjee, R.
Human cystathionine beta-synthase is a target for sumoylation
Biochemistry
45
13528-13536
2006
Homo sapiens
Cherney, M.M.; Pazicni, S.; Frank, N.; Marvin, K.A.; Kraus, J.P.; Burstyn, J.N.
Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process
Biochemistry
46
13199-13210
2007
Homo sapiens
Sen, S.; Banerjee, R.
A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer
Biochemistry
46
4110-4116
2007
Homo sapiens
Liang, R.; Yu, W.; Du, J.; Yang, L.; Shang, M.; Guo, J.
Localization of cystathionine beta synthase in mice ovaries and its expression profile during follicular development
Chin. Med. J.
119
1877-1883
2006
Mus musculus
Hamelet, J.; Ait-Yahya-Graison, E.; Matulewicz, E.; Noll, C.; Badel-Chagnon, A.; Camproux, A.C.; Demuth, K.; Paul, J.L.; Delabar, J.M.; Janel, N.
Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice
Eur. J. Clin. Invest.
37
933-938
2007
Mus musculus
Persa, C.; Osmotherly, K.; Chao-Wei Chen, K.; Moon, S.; Lou, M.F.
The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense
Exp. Eye Res.
83
817-823
2006
Sus scrofa
Linnebank, M.; Semmler, A.; Kleijer, W.J.; van der Sterre, M.L.; Gaertner, J.; Fliessbach, K.; Sokolowski, P.; Koehler, W.; Schlegel, U.; Klockgether, T.; Wanders, R.J.; Schmidt, S.; Wuellner, U.; Kemp, S.
The cystathionine beta-synthase variant c.844_845ins68 protects against CNS demyelination in X-linked adrenoleukodystrophy
Hum. Mutat.
27
1063-1064
2006
Homo sapiens
Chen, X.; Wang, L.; Fazlieva, R.; Kruger, W.D.
Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response
Hum. Mutat.
27
474-482
2006
Homo sapiens
Vyletal, P.; Sokolova, J.; Cooper, D.N.; Kraus, J.P.; Krawczak, M.; Pepe, G.; Rickards, O.; Koch, H.G.; Linnebank, M.; Kluijtmans, L.A.; Blom, H.J.; Boers, G.H.; Gaustadnes, M.; Skovby, F.; Wilcken, B.; Wilcken, D.E.; Andria, G.; Sebastio, G.; Naughten, E.R.; Yap, S.; Ohura, T.; Pronicka, E.; Laszlo, A.; Ko, K.o.z.
Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion
Hum. Mutat.
28
255-264
2007
Homo sapiens
Chen, C.; Beattie, G.A.
Characterization of the osmoprotectant transporter OpuC from Pseudomonas syringae and demonstration that cystathionine-beta-synthase domains are required for its osmoregulatory function
J. Bacteriol.
189
6901-6912
2007
Pseudomonas syringae
Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G.
Dynamics of carbon monoxide binding to cystathionine beta-synthase
J. Biol. Chem.
281
13433-13438
2006
Homo sapiens (P35520)
Yamanishi, M.; Kabil, O.; Sen, S.; Banerjee, R.
Structural insights into pathogenic mutations in heme-dependent cystathionine-beta-synthase
J. Inorg. Biochem.
100
1988-1995
2006
Homo sapiens (P35520), Homo sapiens
Proudfoot, M.; Sanders, S.A.; Singer, A.; Zhang, R.; Brown, G.; Binkowski, A.; Xu, L.; Lukin, J.A.; Murzin, A.G.; Joachimiak, A.; Arrowsmith, C.H.; Edwards, A.M.; Savchenko, A.V.; Yakunin, A.F.
Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain
J. Mol. Biol.
375
301-315
2008
Pyrococcus furiosus, Pyrococcus horikoshii, Thermoplasma acidophilum, Thermoplasma volcanium
Singh, L.R.; Chen, X.; Kozich, V.; Kruger, W.D.
Chemical chaperone rescue of mutant human cystathionine beta-synthase
Mol. Genet. Metab.
91
335-342
2007
Homo sapiens
Singh, S.; Madzelan, P.; Banerjee, R.
Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase
Nat. Prod. Rep.
24
631-639
2007
Homo sapiens (P35520)
Prudova, A.; Bauman, Z.; Braun, A.; Vitvitsky, V.; Lu, S.C.; Banerjee, R.
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity
Proc. Natl. Acad. Sci. USA
103
6489-6494
2006
Homo sapiens, Mus musculus
Liang, R.; Yu, W.D.; Du, J.B.; Yang, L.J.; Yang, J.J.; Xu, J.; Shang, M.; Guo, J.Z.
Cystathionine beta synthase participates in murine oocyte maturation mediated by homocysteine
Reprod. Toxicol.
24
89-96
2007
Mus musculus (Q91WT9), Mus musculus
Summers, C.M.; Hammons, A.L.; Mitchell, L.E.; Woodside, J.V.; Yarnell, J.W.; Young, I.S.; Evans, A.; Whitehead, A.S.
Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations
Eur. J. Hum. Genet.
16
1010-1013
2008
Homo sapiens
Ott, N.; Geddert, H.; Sarbia, M.
Polymorphisms in methionine synthase (A2756G) and cystathionine beta-synthase (844ins68) and susceptibility to carcinomas of the upper gastrointestinal tract
J. Cancer Res. Clin. Oncol.
134
405-410
2008
Homo sapiens
Jeong, B.C.; Yoo, K.S.; Jung, K.W.; Shin, J.S.; Song, H.K.
Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine beta-synthase domain-containing protein, CDCP2, from Arabidopsis thaliana
Acta Crystallogr. Sect. F
64
825-827
2008
Arabidopsis thaliana
Prathapasinghe, G.A.; Siow, Y.L.; Xu, Z.; O, K.
Inhibition of cystathionine-beta-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide
Am. J. Physiol. Renal Physiol.
295
F912-F922
2008
Rattus norvegicus
Carballal, S.; Madzelan, P.; Zinola, C.F.; Grana, M.; Radi, R.; Banerjee, R.; Alvarez, B.
Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase
Biochemistry
47
3194-3201
2008
Homo sapiens
Ozaki, S.; Inada, A.; Sada, K.
Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations
Biosci. Biotechnol. Biochem.
72
2318-2323
2008
Homo sapiens (P35520), Homo sapiens
Ozaki, S.; Doi, M.; Migita, C.T.
Modulation of cystathionine beta-synthase activity by altering heme environment
Chem. Lett.
37
208-209
2008
Homo sapiens
-
Jakubowski, H.; Boers, G.H.; Strauss, K.A.
Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans
FASEB J.
22
4071-4076
2008
Homo sapiens
Romano, M.; Bacalini, M.G.; Verschoor, E.J.; Crovella, S.; Baralle, F.E.
Origin and evolution of the c.844_845ins68/c.833T>C mutations within the cystathionine beta-synthase gene in great apes
FEBS Lett.
582
423-426
2008
Chlorocebus aethiops, Macaca fascicularis, Gorilla gorilla, Macaca fuscata, Pan troglodytes, Papio hamadryas, Pongo pygmaeus, Pan paniscus, Macaca arctoides, Nomascus gabriellae, Nomascus leucogenys
Shintani, T.; Iwabuchi, T.; Soga, T.; Kato, Y.; Yamamoto, T.; Takano, N.; Hishiki, T.; Ueno, Y.; Ikeda, S.; Sakuragawa, T.; Ishikawa, K.; Goda, N.; Kitagawa, Y.; Kajimura, M.; Matsumoto, K.; Suematsu, M.
Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion
Hepatology
49
141-150
2009
Mus musculus, Rattus norvegicus
Gupta, S.; Wang, L.; Hua, X.; Krijt, J.; Kozich, V.; Kruger, W.D.
Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice
Hum. Mutat.
29
1048-1054
2008
Homo sapiens
Majtan, T.; Singh, L.R.; Wang, L.; Kruger, W.D.; Kraus, J.P.
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone
J. Biol. Chem.
283
34588-34595
2008
Homo sapiens
Belew, M.S.; Quazi, F.I.; Willmore, W.G.; Aitken, S.M.
Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli
Protein Expr. Purif.
64
139-145
2009
Homo sapiens
Cao, Q.; Zhang, L.; Yang, G.; Xu, C.; Wang, R.
Butyrate-stimulated H2S production in colon cancer cells
Antioxid. Redox Signal.
12
1101-1109
2010
Homo sapiens
Celano, L.; Gil, M.; Carballal, S.; Duran, R.; Denicola, A.; Banerjee, R.; Alvarez, B.
Inactivation of cystathionine beta-synthase with peroxynitrite
Arch. Biochem. Biophys.
491
96-105
2009
Homo sapiens (P35520)
Lodha, P.H.; Shadnia, H.; Woodhouse, C.M.; Wright, J.S.; Aitken, S.M.
Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase
Biochem. Cell Biol.
87
531-540
2009
Saccharomyces cerevisiae
Quazi, F.; Aitken, S.M.
Characterization of the S289A,D mutants of yeast cystathionine beta-synthase
Biochim. Biophys. Acta
1794
892-897
2009
Saccharomyces cerevisiae
Ganapathy, P.S.; Moister, B.; Roon, P.; Mysona, B.A.; Duplantier, J.; Dun, Y.; Moister, T.K.; Farley, M.J.; Prasad, P.D.; Liu, K.; Smith, S.B.
Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse
Invest. Ophthalmol. Vis. Sci.
50
4460-4470
2009
Mus musculus
Weeks, C.L.; Singh, S.; Madzelan, P.; Banerjee, R.; Spiro, T.G.
Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy
J. Am. Chem. Soc.
131
12809-12816
2009
Homo sapiens
Singh, L.; Kruger, W.
Functional rescue of mutant human cystathionine -synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae
J. Biol. Chem.
284
4238-4245
2009
Homo sapiens
Majtan, T.; Liu, L.; Carpenter, J.F.; Kraus, J.P.
Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes
J. Biol. Chem.
285
15866-15873
2010
Homo sapiens
Xu, Y.Y.; Guan, D.Y.; Yang, M.; Wang, H.; Shen, Z.H.
All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism
J. Cell. Biochem.
109
468-477
2010
Homo sapiens
Singh, S.; Madzelan, P.; Stasser, J.; Weeks, C.L.; Becker, D.; Spiro, T.G.; Penner-Hahn, J.; Banerjee, R.
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation
J. Inorg. Biochem.
103
689-697
2009
Homo sapiens
Karunakaran, V.; Benabbas, A.; Sun, Y.; Zhang, Z.; Singh, S.; Banerjee, R.; Champion, P.M.
Investigations of low-frequency vibrational dynamics and ligand binding kinetics of cystathionine beta-synthase
J. Phys. Chem. B
114
3294-3306
2010
Homo sapiens
Chao, W.H.; Reynolds, R.D.
Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice
Nutr. Res.
29
794-801
2009
Mus musculus
Kim, J.; Hong, S.J.; Park, J.H.; Park, S.Y.; Kim, S.W.; Cho, E.Y.; Do, I.G.; Joh, J.W.; Kim, D.S.
Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis
Oncol. Rep.
21
1449-1454
2009
Homo sapiens
Ozaki, S.; Sakaguchi, C.; Nakahara, A.; Yoshiya, M.
Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions
Protein Pept. Lett.
17
351-355
2010
Homo sapiens
Majtan, T.; Freeman, K.M.; Smith, A.T.; Burstyn, J.N.; Kraus, J.P.
Purification and characterization of cystathionine beta-synthase bearing a cobalt protoporphyrin
Arch. Biochem. Biophys.
508
25-30
2011
Homo sapiens
Ishikawa, K.; Mino, K.; Nakamura, T.
New function and application of the cysteine synthase from archaea
Biochem. Eng. J.
48
315-322
2010
Saccharomyces cerevisiae (P32582), Homo sapiens (P35520), Aeropyrum pernix (Q9YCN5)
-
Hnizda, A.; Spiwok, V.; Jurga, V.; Kozich, V.; Kodicek, M.; Kraus, J.P.
Cross-talk between the catalytic core and the regulatory domain in cystathionine beta-synthase: study by differential covalent labeling and computational modeling
Biochemistry
49
10526-10534
2010
Homo sapiens
Singh, S.; Ballou, D.; Banerjee, R.
Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine beta-synthase-catalyzed H2S generation
Biochemistry
50
419-425
2011
Saccharomyces cerevisiae
Jensen, K.K.; Geoghagen, N.S.; Jin, L.; Holt, T.G.; Luo, Q.; Malkowitz, L.; Ni, W.; Quan, S.; Waters, M.G.; Zhang, A.; Zhou, H.H.; Cheng, K.; Luo, M.J.
Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice
Eur. J. Pharmacol.
650
86-93
2011
Homo sapiens, Mus musculus, Rattus norvegicus
Kozich, V.; Sokolova, J.; Klatovska, V.; Krijt, J.; Janosik, M.; Jelinek, K.; Kraus, J.P.
Cystathionine beta-synthase mutations: effect of mutation topology on folding and activity
Hum. Mutat.
31
809-819
2010
Homo sapiens (P35520), Homo sapiens
Smith, A.T.; Majtan, T.; Freeman, K.M.; Su, Y.; Kraus, J.P.; Burstyn, J.N.
Cobalt cystathionine beta-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif
Inorg. Chem.
50
4417-4427
2011
Homo sapiens
Kopecka, J.; Krijt, J.; Rakova, K.; Kozich, V.
Restoring assembly and activity of cystathionine beta-synthase mutants by ligands and chemical chaperones
J. Inherit. Metab. Dis.
34
39-48
2011
Homo sapiens
Krijt, J.; Kopecka, J.; Hnizda, A.; Moat, S.; Kluijtmans, L.A.; Mayne, P.; Kozich, V.
Determination of cystathionine beta-synthase activity in human plasma by LC-MS/MS: potential use in diagnosis of CBS deficiency
J. Inherit. Metab. Dis.
34
49-55
2011
Homo sapiens
Koutmos, M.; Kabil, O.; Smith, J.L.; Banerjee, R.
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine beta-synthase
Proc. Natl. Acad. Sci. USA
107
20958-20963
2010
Drosophila melanogaster (Q9VRD9)
Albertini, E.; Koziel, R.; Duerr, A.; Neuhaus, M.; Jansen-Duerr, P.
Cystathionine beta synthase modulates senescence of human endothelial cells
Aging
4
664-673
2012
Homo sapiens
Katko, M.; Zavaczki, E.; Jeney, V.; Paragh, G.; Balla, J.; Varga, Z.
Homocysteine metabolism in peripheral blood mononuclear cells: evidence for cystathionine beta-synthase activity in resting state
Amino Acids
43
317-326
2012
Homo sapiens
Casique, L.; Kabil, O.; Banerjee, R.; Martinez, J.C.; De Lucca, M.
Characterization of two pathogenic mutations in cystathionine beta-synthase: different intracellular locations for wild-type and mutant proteins
Gene
531
117-124
2013
Homo sapiens (P35520), Homo sapiens
Hnizda, A.; Jurga, V.; Rakova, K.; Kozich, V.
Cystathionine beta-synthase mutants exhibit changes in protein unfolding: conformational analysis of misfolded variants in crude cell extracts
J. Inherit. Metab. Dis.
35
469-477
2012
Homo sapiens
Mendes, M.I.; Colaco, H.G.; Smith, D.E.; Ramos, R.J.; Pop, A.; van Dooren, S.J.; Tavares de Almeida, I.; Kluijtmans, L.A.; Janssen, M.C.; Rivera, I.; Salomons, G.S.; Leandro, P.; Blom, H.J.
Reduced response of cystathionine beta-synthase (CBS) to S-adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in homocystinuria patients
J. Inherit. Metab. Dis.
37
245-254
2014
Homo sapiens
Bruintjes, J.J.; Henning, R.H.; Douwenga, W.; van der Zee, E.A.
Hippocampal cystathionine beta synthase in young and aged mice
Neurosci. Lett.
563
135-139
2014
Mus musculus
Bhattacharyya, S.; Saha, S.; Giri, K.; Lanza, I.R.; Nair, K.S.; Jennings, N.B.; Rodriguez-Aguayo, C.; Lopez-Berestein, G.; Basal, E.; Weaver, A.L.; Visscher, D.W.; Cliby, W.; Sood, A.K.; Bhattacharya, R.; Mukherjee, P.
Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance
PLoS ONE
8
e79167
2013
Homo sapiens
Ereno-Orbea, J.; Majtan, T.; Oyenarte, I.; Kraus, J.P.; Martinez-Cruz, L.A.
Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine beta-synthase from Saccharomyces cerevisiae
Acta Crystallogr. Sect. F
70
320-325
2014
Saccharomyces cerevisiae (P32582), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P32582)
Romero, I.; Tellez, J.; Romanha, A.J.; Steindel, M.; Grisard, E.C.
Upregulation of cysteine synthase and cystathionine beta-synthase contributes to Leishmania braziliensis survival under oxidative stress
Antimicrob. Agents Chemother.
59
4770-4781
2015
Leishmania braziliensis (A4H8W8)
Majtan, T.; Krijt, J.; Sokolova, J.; Krizkova, M.; Ralat, M.A.; Kent, J.; Gregory, J.F.; Kozich, V.; Kraus, J.P.
Biogenesis of hydrogen sulfide and thioethers by cystathionine beta-synthase
Antioxid. Redox Signal.
28
311-323
2018
Homo sapiens (P35520)
Feng, N.; Qi, C.; Hou, Y.J.; Zhang, Y.; Wang, D.C.; Li, D.F.
The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain
Biochem. Biophys. Res. Commun.
497
646-651
2018
Escherichia coli
Tu, Y.; Kreinbring, C.A.; Hill, M.; Liu, C.; Petsko, G.A.; McCune, C.D.; Berkowitz, D.B.; Liu, D.; Ringe, D.
Crystal structures of cystathionine beta-synthase from Saccharomyces cerevisiae One enzymatic step at a time
Biochemistry
57
3134-3145
2018
Saccharomyces cerevisiae (P32582), Saccharomyces cerevisiae
Pey, A.L.; Majtan, T.; Kraus, J.P.
The role of surface electrostatics on the stability, function and regulation of human cystathionine beta-synthase, a complex multidomain and oligomeric protein
Biochim. Biophys. Acta
1844
1453-1462
2014
Homo sapiens (P35520)
Majtan, T.; Pey, A.L.; Kraus, J.P.
Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine Potential approach to pharmacological chaperone therapy for homocystinuria
Biochimie
126
6-13
2016
Homo sapiens (P35520), Homo sapiens
Thorson, M.; Van Wagoner, R.; Harper, M.; Ireland, C.; Majtan, T.; Kraus, J.; Barrios, A.
Marine natural products as inhibitors of cystathionine beta-synthase activity
Bioorg. Med. Chem. Lett.
25
1070-1072
2015
Homo sapiens
Nakabayashi, M.; Shibata, N.; Ishido-Nakai, E.; Kanagawa, M.; Iio, Y.; Komori, H.; Ueda, Y.; Nakagawa, N.; Kuramitsu, S.; Higuchi, Y.
Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-beta-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains
Extremophiles
20
275-282
2016
Thermus thermophilus (Q5SK23)
Saha, S.; Chakraborty, P.K.; Xiong, X.; Dwivedi, S.K.; Mustafi, S.B.; Leigh, N.R.; Ramchandran, R.; Mukherjee, P.; Bhattacharya, R.
Cystathionine beta-synthase regulates endothelial function via protein S-sulfhydration
FASEB J.
30
441-456
2016
Homo sapiens
Chakraborty, P.K.; Murphy, B.; Mustafi, S.B.; Dey, A.; Xiong, X.; Rao, G.; Naz, S.; Zhang, M.; Yang, D.; Dhanasekaran, D.N.; Bhattacharya, R.; Mukherjee, P.
Cystathionine beta-synthase regulates mitochondrial morphogenesis in ovarian cancer
FASEB J.
32
4145-4157
2018
Homo sapiens
Devi, S.; Abdul Rehman, S.A.; Tarique, K.F.; Gourinath, S.
Structural characterization and functional analysis of cystathionine beta-synthase an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis
FEBS J.
284
3862-3880
2017
Bacillus anthracis (A0A1J9VES8), Bacillus anthracis
Pey, A.L.; Martinez-Cruz, L.A.; Kraus, J.P.; Majtan, T.
Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding
FEBS Lett.
590
4461-4471
2016
Homo sapiens (P35520), Homo sapiens
Sen, S.; Kawahara, B.; Gupta, D.; Tsai, R.; Khachatryan, M.; Roy-Chowdhuri, S.; Bose, S.; Yoon, A.; Faull, K.; Farias-Eisner, R.; Chaudhuri, G.
Role of cystathionine beta-synthase in human breast cancer
Free Radic. Biol. Med.
86
228-238
2015
Homo sapiens
Prabhudesai, S.; Koceja, C.; Dey, A.; Eisa-Beygi, S.; Leigh, N.; Bhattacharya, R.; Mukherjee, P.; Ramchandran, R.
Cystathionine beta-synthase is necessary for axis development in vivo
Front. Cell Dev. Biol.
6
14
2018
Danio rerio
Mendes, M.I.; Santos, A.S.; Smith, D.E.; Lino, P.R.; Colaco, H.G.; de Almeida, I.T.; Vicente, J.B.; Salomons, G.S.; Rivera, I.; Blom, H.J.; Leandro, P.
Insights into the regulatory domain of cystathionine beta-synthase characterization of six variant proteins
Hum. Mutat.
35
1195-1202
2014
Homo sapiens (P35520)
Hirata, Y.; Funato, Y.; Takano, Y.; Miki, H.
Mg2+-dependent interactions of ATP with the cystathionine-beta-synthase (CBS) domains of a magnesium transporter
J. Biol. Chem.
289
14731-14739
2014
Mus musculus (Q3TWN3)
Vicente, J.B.; Colaco, H.G.; Sarti, P.; Leandro, P.; Giuffre, A.
S-Adenosyl-L-methionine modulates CO and NO* binding to the human H2S-generating enzyme cystathionine beta-synthase
J. Biol. Chem.
291
572-581
2016
Homo sapiens (P35520), Homo sapiens
Carballal, S.; Cuevasanta, E.; Yadav, P.K.; Gherasim, C.; Ballou, D.P.; Alvarez, B.; Banerjee, R.
Kinetics of nitrite reduction and peroxynitrite formation by ferrous heme in human cystathionine beta-synthase
J. Biol. Chem.
291
8004-8013
2016
Homo sapiens (P35520), Homo sapiens
Niu, W.; Wang, J.; Qian, J.; Wang, M.; Wu, P.; Chen, F.; Yan, S.
Allosteric control of human cystathionine beta-synthase activity by a redox active disulfide bond
J. Biol. Chem.
293
2523-2533
2018
Homo sapiens
Gimenez-Mascarell, P.; Majtan, T.; Oyenarte, I.; Ereno-Orbea, J.; Majtan, J.; Klaudiny, J.; Kraus, J.P.; Martinez-Cruz, L.A.
Crystal structure of cystathionine beta-synthase from honeybee Apis mellifera
J. Struct. Biol.
202
82-93
2018
Apis mellifera (Q2V0C9), Apis mellifera
Chakraborty, P.K.; Xiong, X.; Mustafi, S.B.; Saha, S.; Dhanasekaran, D.; Mandal, N.A.; McMeekin, S.; Bhattacharya, R.; Mukherjee, P.
Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
Oncotarget
6
37367-37384
2015
Homo sapiens
Majtan, T.; Pey, A.L.; Fernandez, R.; Fernandez, J.A.; Martinez-Cruz, L.A.; Kraus, J.P.
Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases
PLoS ONE
9
e105290
2014
Drosophila melanogaster, Homo sapiens, Saccharomyces cerevisiae
Ereno-Orbea, J.; Majtan, T.; Oyenarte, I.; Kraus, J.P.; Martinez-Cruz, L.A.
Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine
Proc. Natl. Acad. Sci. USA
111
E3845-E3852
2014
Homo sapiens (P35520), Homo sapiens
Matoba, Y.; Yoshida, T.; Izuhara-Kihara, H.; Noda, M.; Sugiyama, M.
Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum
Protein Sci.
26
763-783
2017
Lactiplantibacillus plantarum (F9UT54), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 (F9UT54)
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