4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase
This is an abbreviated version!
For detailed information about (R)-2-hydroxyisocaproyl-CoA dehydratase, go to the full flat file.
Word Map on EC 4.2.1.157
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4.2.1.157
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mycolic
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hadab
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tuberculosis
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fas-ii
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ketyl
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difficile
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clostridia
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2-hydroxyacyl-coa
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thiacetazone
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antitubercular
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isoxyl
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nitrogenase
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3-hydroxyacyl
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2-hydroxyglutaryl-coa
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benzoyl-coa
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oxygen-sensitive
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fermentans
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acidaminococcus
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symbiosum
- 4.2.1.157
-
mycolic
-
hadab
- tuberculosis
- fas-ii
-
ketyl
- difficile
- clostridia
-
2-hydroxyacyl-coa
- thiacetazone
-
antitubercular
- isoxyl
- nitrogenase
-
3-hydroxyacyl
-
2-hydroxyglutaryl-coa
- benzoyl-coa
-
oxygen-sensitive
- fermentans
-
acidaminococcus
- symbiosum
Reaction
Synonyms
2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase
ECTree
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Systematic Name
Systematic Name on EC 4.2.1.157 - (R)-2-hydroxyisocaproyl-CoA dehydratase
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(R)-2-hydroxy-4-methylpentanoyl-CoA hydro-lyase
The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation. It catalyses an alpha/beta-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.