4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase
This is an abbreviated version!
For detailed information about (R)-2-hydroxyisocaproyl-CoA dehydratase, go to the full flat file.
Word Map on EC 4.2.1.157
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4.2.1.157
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mycolic
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hadab
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tuberculosis
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fas-ii
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ketyl
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difficile
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clostridia
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2-hydroxyacyl-coa
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thiacetazone
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antitubercular
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isoxyl
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nitrogenase
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3-hydroxyacyl
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2-hydroxyglutaryl-coa
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benzoyl-coa
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oxygen-sensitive
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fermentans
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acidaminococcus
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symbiosum
- 4.2.1.157
-
mycolic
-
hadab
- tuberculosis
- fas-ii
-
ketyl
- difficile
- clostridia
-
2-hydroxyacyl-coa
- thiacetazone
-
antitubercular
- isoxyl
- nitrogenase
-
3-hydroxyacyl
-
2-hydroxyglutaryl-coa
- benzoyl-coa
-
oxygen-sensitive
- fermentans
-
acidaminococcus
- symbiosum
Reaction
Synonyms
2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase
ECTree
4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydrataseAdvanced search results
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results (Inhibitors
Inhibitors on EC 4.2.1.157 - (R)-2-hydroxyisocaproyl-CoA dehydratase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
AlF4-
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AlF4 in combination with ADP traps the interaction of the activator protein with the dehydratase by forming a stable complex containing 1.0 mol homodimeric activator, 1.0 mol heterodimeric dehydratase and 1.2 mol ADP. The formation proceeds much slower than the activation but in an almost irreversible manner. The isolated complex is devoid of any activity
bathophenanthroline
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a [4Fe-4S] cluster-containing protein activates 2-hydroxyisocaproyl-CoA dehydratase by an ATP-driven electron transfer. Iron chelation by bathophenanthroline removes the reduced [4Fe-4S] cluster from the activator protein in an ATP-dependent manner. With ADP, no chelation is observed. Chelation of the oxidised [4Fe-4S] cluster occurs faster with ADP than with ATP
