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4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase

This is an abbreviated version!
For detailed information about (R)-2-hydroxyisocaproyl-CoA dehydratase, go to the full flat file.

Word Map on EC 4.2.1.157

Reaction

(R)-2-hydroxy-4-methylpentanoyl-CoA
=
4-methylpent-2-enoyl-CoA
 +
H2O

Synonyms

2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase

Metals Ions

Metals Ions on EC 4.2.1.157 - (R)-2-hydroxyisocaproyl-CoA dehydratase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
besides varying amounts of zinc, other metal ions, particularly molybdenum, are not detected in the dehydratase
[4Fe-4S] center
the crystal structure reveals that the heterodimeric protein contains two [4Fe-4S] clusters at a distance of 12 A, each coordinated by three cysteines and one terminal ligand. The cluster in the alpha-subunit is part of the active site. In the absence of substrate, a water/hydroxide ion acts as the fourth ligand. The substrate replaces this ligand and coordinates the cluster via the carbonyl-oxygen of the thioester group. The cluster in the beta-subunit has a terminal sulfhydryl/sulfido ligand and can act as a reservoir to protect the electron from unwanted side reactions via a recycling mechanism