4.2.1.157: (R)-2-hydroxyisocaproyl-CoA dehydratase
This is an abbreviated version!
For detailed information about (R)-2-hydroxyisocaproyl-CoA dehydratase, go to the full flat file.
Word Map on EC 4.2.1.157
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4.2.1.157
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mycolic
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hadab
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tuberculosis
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fas-ii
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ketyl
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difficile
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clostridia
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2-hydroxyacyl-coa
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thiacetazone
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antitubercular
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isoxyl
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nitrogenase
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3-hydroxyacyl
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2-hydroxyglutaryl-coa
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benzoyl-coa
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oxygen-sensitive
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fermentans
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acidaminococcus
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symbiosum
- 4.2.1.157
-
mycolic
-
hadab
- tuberculosis
- fas-ii
-
ketyl
- difficile
- clostridia
-
2-hydroxyacyl-coa
- thiacetazone
-
antitubercular
- isoxyl
- nitrogenase
-
3-hydroxyacyl
-
2-hydroxyglutaryl-coa
- benzoyl-coa
-
oxygen-sensitive
- fermentans
-
acidaminococcus
- symbiosum
Reaction
Synonyms
2-hydroxyisocaproyl-CoA dehydratase, HadBC, HadBC dehydratase
ECTree
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Cofactor
Cofactor on EC 4.2.1.157 - (R)-2-hydroxyisocaproyl-CoA dehydratase
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[4Fe-4S]-center
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a [4Fe-4S] cluster-containing protein activates 2-hydroxyisocaproyl-CoA dehydratase by an ATP-driven electron transfer. Iron chelation by bathophenanthroline removes the reduced [4Fe-4S] cluster from the activator protein in an ATP-dependent manner. With ADP, no chelation is observed. Chelation of the oxidised [4Fe-4S] cluster occurs faster with ADP than with ATP