4.1.99.3: deoxyribodipyrimidine photo-lyase
This is an abbreviated version!
For detailed information about deoxyribodipyrimidine photo-lyase, go to the full flat file.
Word Map on EC 4.1.99.3
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4.1.99.3
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single-stranded
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strand
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dsdna
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helicase
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aptamer
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fork
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duplex
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electrochemical
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electrode
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nanoparticles
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viruses
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bacteriophage
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unwind
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gold
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biosensors
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rpa
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nuclease
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exonuclease
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selex
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photoproducts
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polymerases
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uv-induced
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rad51
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graphene
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single-molecule
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nucleoprotein
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anneal
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primer-template
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telomeres
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biotechnology
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biosensing
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okazaki
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analysis
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recombinases
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aptasensors
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translesion
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anti-dna
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aptamer-based
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dna-dependent
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dnab
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g-quadruplexes
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overhang
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template-primer
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recbcd
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oligoribonucleotides
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replisome
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nanopore
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apobec3g
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loader
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aunps
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mre11
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blue-light
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medicine
- 4.1.99.3
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single-stranded
- strand
- dsdna
- helicase
- aptamer
- fork
- duplex
-
electrochemical
-
electrode
- nanoparticles
- viruses
- bacteriophage
-
unwind
- gold
-
biosensors
- rpa
- nuclease
-
exonuclease
-
selex
- photoproducts
- polymerases
-
uv-induced
- rad51
-
graphene
-
single-molecule
- nucleoprotein
-
anneal
-
primer-template
-
telomeres
- biotechnology
-
biosensing
-
okazaki
- analysis
-
recombinases
-
aptasensors
-
translesion
-
anti-dna
-
aptamer-based
-
dna-dependent
- dnab
-
g-quadruplexes
-
overhang
-
template-primer
-
recbcd
- oligoribonucleotides
- replisome
-
nanopore
- apobec3g
-
loader
-
aunps
- mre11
-
blue-light
- medicine
Reaction
Synonyms
AMV025, AnPL, AtCry1, AtCry3, AtPL, BcCRY1, BcCRY2, BCIN_05g08060, BCIN_09g01620, BsUvrC, Cc-phr2, CcPL, CDP photolyase, class I CPD photolyase, class I cyclobutane pyrimidine dimer photolyase, class I photolyase, class I PL, class II AtPL, class II CPD photolyase, class II CPD-DNA photolyase, class II CPD-photolyase, class II cyclobutane pyrimidine dimer photolyase, class II DmPL, class II DNA photolyase, class II photolyase, class II PL, class III PL, cold-adapted DNA photolyase, CPD class I photolyase, CPD photolyase, CPD photolyase photolyase, CPD specific photolyase, CPD-class I photolyase, CPD-photolyase, CPD-Phr, CPD-specific DNA photolyase, CPD1, CPD2PHR, CPDI, CPDII, CPDphr, CPH1, CPH1-PHR, CpPL, Cry-DASH, Cry1, Cry2, cry3, CryA, CRYD, cryptochrome 1, cryptochrome 3, CRYPTOCHROME DASH, cryptochrome-3, cryptochrome-DASH, CsPHR, cyclobutane pyrimidine dimer photolyase, cyclobutane pyrimidine dimer PHR, cyclobutane pyrimidine dimer specific photolyase, cyclobutane pyrimidine dimer-class I photolyase, cyclobutane pyrimidine dimer-specific DNA photolyase, cyclobutane pyrimidine dimers photolyase, CYME_CMA044C, cytochrome DASH, DASH cryptochrome, deoxyribodipyrimidine photolyase, deoxyribodipyrimidine photolyase type I enzyme, deoxyribonucleate pyrimidine dimer lyase (photosensitive), deoxyribonucleic cyclobutane dipyrimidine photolyase, deoxyribonucleic photolyase, dipyrimidine photolyase (photosensitive), DmPL, DNA cyclobutane dipyrimidine photolyase, DNA photolyase, DNA photolyase type I enzyme, DNA repair protein photolyase, DNA-photoreactivating enzyme, EcPL, eukaryotic Class II CPD PHR, eukaryotic class II cyclobutane pyrimidine dimer photolyase, lyase, deoxyribonucleate pyrimidine dimer, MmCPDII, MmPL, MM_0852, photolyase, photolyase I, photolyase orthologue, photoreactivating enzyme, PHR, phr A photolyase, PHR1, PHR2, phrA, PhrB, PhrB orthologue, PhrB photolyase, PL, PRE, primase, Saci_1227, ssDNA, ssDNA AtCRY3, ssDNA photolyase, ssDNA PL, SsPL, St-photolyase, tetur12g04440, tetur12g04460, tetur35g00010, tetur35g00030, thymine dimer by photolyase, VcCry1, VcPHR, Ver3Phr, VPA1471, XlCry-DASH
ECTree
4.1.99.3 deoxyribodipyrimidine photo-lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.99.3 - deoxyribodipyrimidine photo-lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Caulobacter vibrioides NA1000 / CB15N
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Caulobacter vibrioides NA1000/CB15N
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Colwellia psychrerythraea 34H / ATCC BAA-681
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
photolyases utilize near-ultraviolet blue light to specifically repair the major photoproducts of UV-induced damaged DNA. The enzyme specifically repairs CPD lesions
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
the enzyme catalyses light-driven DNA repair and photoreduction, but in contrast to class I enzymes lacks a high degree of binding discrimination between UV-damaged and intact duplex DNA
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
the enzyme catalyses light-driven DNA repair and photoreduction, but in contrast to class I enzymes lacks a high degree of binding discrimination between UV-damaged and intact duplex DNA
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Saccharolobus solfataricus DSM ATCC 35092 / DSM 1617 / JCM 11322 / P2
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
the enzyme is involved in biological photoreactivation
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
the enzyme is involved in biological photoreactivation
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Synechococcus elongatus PCC 7942 = FACHB-805 ATCC 27144 / PCC 6301 / SAUG 1402/1
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Vibrio cholerae serotype O1 ATCC 39315 / El Tor Inaba N16961
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
-
-
-
-
?
cyclobutadipyrimidine (in DNA)
2 pyrimidine residues (in DNA)
Xiphophorus maculatus Jp 163 B
-
-
-
-
?
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
-
-
-
?
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
-
-
?
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
-
-
-
?
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
-
-
?
cyclobutadipyrimidine in DNA
2 pyrimidine residues in DNA
-
DNA repair activity
-
?
cyclobutadipyrimidine in DNA
?
-
the enzyme binds to DNA containing pyrimidine dimers with high affinity and then breaks the cyclobutane ring joining the two pyrimidines of the dimer in a light-dependent reaction, 300-500 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
light-dependent(300-600 nm) monomerization of cyclobutyl pyrimidine dimers, formed between adjacent pyrimidines on the same DNA strand, upon exposure to UV irradiation, 220-320 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
the enzyme converts the energy of light of near UV to visible wavelengths into chemical energy to break the cyclobutane ring of pyrimidine dimers in DNA and thus prevents the lethal and mutagenic effects of far UV, 200-300 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
light-dependent(300-600 nm) monomerization of cyclobutyl pyrimidine dimers, formed between adjacent pyrimidines on the same DNA strand, upon exposure to UV irradiation, 220-320 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
the enzyme converts the energy of light of near UV to visible wavelengths into chemical energy to break the cyclobutane ring of pyrimidine dimers in DNA and thus prevents the lethal and mutagenic effects of far UV, 200-300 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
light-dependent(300-600 nm) monomerization of cyclobutyl pyrimidine dimers, formed between adjacent pyrimidines on the same DNA strand, upon exposure to UV irradiation, 220-320 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
the enzyme converts the energy of light of near UV to visible wavelengths into chemical energy to break the cyclobutane ring of pyrimidine dimers in DNA and thus prevents the lethal and mutagenic effects of far UV, 200-300 nm
-
-
?
cyclobutadipyrimidine in DNA
?
-
light-dependent(300-600 nm) monomerization of cyclobutyl pyrimidine dimers, formed between adjacent pyrimidines on the same DNA strand, upon exposure to UV irradiation, 220-320 nm
-
-
?
cyclobutadipyrimidine in DNA
pyrimidine residues in DNA
-
DNA repair enzyme can absorb blue/ultraviolet A light as energy and split a pyrimidine dimer induced by ultraviolet radiation. PHR1 gene encodes a functional photolyase. The PHR1 transcripts are specifically enhanced by near-ultraviolet radiation (300-400 nm) and by sunlight
-
-
?
cyclobutadipyrimidine in DNA
pyrimidine residues in DNA
the enzyme is one of the main factors determining UVB sensitivity in Oryza sativa. Cultivar Sasanishiki is resistant to the damaging effects of UVB while cultivar Norin 1 is less resistant. Amino acid position 126 is Arg in cultivar Norin 1 and Gln in cultivar Sasanishiki. The single amino acid alteration from Gln to Arg leads to a deficit of CPD photolyase activity
-
-
?
additional information
?
-
light-dependent repair of UV-induced damage products in DNA by direct reversal of base damage rather than via excision repair pathways
-
?
additional information
?
-
-
light-dependent repair of UV-induced damage products in DNA by direct reversal of base damage rather than via excision repair pathways
-
?
additional information
?
-
-
pre-inoculation UV-C (254 nm) treatment of normally susceptible Arabidopsis thaliana accessions induces prolonged, dose-dependent resistance to virulent isolates of the phytopathogenic oomycete Hyaloperonospora parasitica with cyclobutane pyrimidine dimers and (6-4) photoproducts playing a key role in this response
-
-
?
additional information
?
-
-
CryA can repair DNA upon exposure to UVA light similar to other photolyase proteins, CryA represses sexual development under UVA350-370 nm light and exhibits a regulatory function during light-dependent development and DNA repair activity, in the wild type strain mechanisms such as excision repair mask the DNA photolyase activity of CryA
-
-
?
additional information
?
-
the enzyme has blue light photoreceptor activity and CPD photolyase activity. Signaling might be mediated by the PHR besides its effects on the C-terminal extension, conformational changes in cryptochromes upon illumination, overview
-
-
?
additional information
?
-
-
the enzyme has blue light photoreceptor activity and CPD photolyase activity. Signaling might be mediated by the PHR besides its effects on the C-terminal extension, conformational changes in cryptochromes upon illumination, overview
-
-
?
additional information
?
-
-
PHR1 and PHR2 are able to bind the CLOCK protein, a transcription activator controlling the molecular circadian clock. But only for PHR2, the physical interaction with CLOCK represses CLOCK/BMAL1-driven transcription, binding of photolyase per se is not sufficient to inhibit the CLOCK/BMAL1 heterodimer
-
-
?
additional information
?
-
-
CPD photolyase, which rapidly repairs CPDs, is essential for plant survival under sunlight containing UVB
-
-
?
additional information
?
-
-
major pathway to remove UV-induced DNA lesions from the genome
-
?
additional information
?
-
-
photoreduction by intraprotein electron transfer is not part of the photolyase photocycle under physiological conditions
-
-
?
additional information
?
-
-
absolute dependence of catalysis by photolyase on light
-
-
?
additional information
?
-
enzyme promotes virus survival in the environment
-
?
additional information
?
-
-
enzyme promotes virus survival in the environment
-
?
additional information
?
-
PhrB does not function as a photolyase
-
-
?
additional information
?
-
-
PhrB does not function as a photolyase
-
-
?
additional information
?
-
PhrB does not function as a photolyase
-
-
?
additional information
?
-
the native rice CPD photolyase is phosphorylated, whereas the Escherichia coli-expressed rice CPD photolyase is not
-
-
?
additional information
?
-
-
expression in transgenic mice leads to superior survival, reduced acute UV effects like erythema, hyperplasia or apoptosis when treated with photoreactivating light
-
?
additional information
?
-
-
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
-
-
?
additional information
?
-
-
photolyase repairs nucleosome-free DNA rapidly, while repair of nucleosomes is inhibited severely
-
?
additional information
?
-
-
predominant role of photolyase is CDP repair of an origin or replication
-
?
additional information
?
-
-
photolyase repairs nucleosome-free DNA rapidly, while repair of nucleosomes is inhibited severely
-
?
additional information
?
-
-
absolute dependence of catalysis by photolyase on light
-
-
?
