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4.1.99.17: phosphomethylpyrimidine synthase

This is an abbreviated version!
For detailed information about phosphomethylpyrimidine synthase, go to the full flat file.

Word Map on EC 4.1.99.17

Reaction

5-amino-1-(5-phospho-D-ribosyl)imidazole
+
S-adenosyl-L-methionine
=
4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
 +
5'-deoxyadenosine
 +
L-methionine
 +
formate
 +
CO

Synonyms

2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.17 phosphomethylpyrimidine synthase

Reference

topprint

Reference on EC 4.1.99.17 - phosphomethylpyrimidine synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chatterjee, A.; Hazra, A.B.; Abdelwahed, S.; Hilmey, D.G.; Begley, T.P.
A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase
Angew. Chem. Int. Ed. Engl.
49
8653-8656
2010
Bacteria
Manually annotated by BRENDA team
Martinez-Gomez, N.C.; Downs, D.M.
ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis
Biochemistry
47
9054-9056
2008
Salmonella enterica subsp. enterica serovar Typhimurium (Q9L9I7)
Manually annotated by BRENDA team
Martinez-Gomez, N.C.; Poyner, R.R.; Mansoorabadi, S.O.; Reed, G.H.; Downs, D.M.
Reaction of AdoMet with ThiC generates a backbone free radical
Biochemistry
48
217-219
2009
Salmonella enterica subsp. enterica serovar Typhimurium (Q9L9I7)
Manually annotated by BRENDA team
Kong, D.; Zhu, Y.; Wu, H.; Cheng, X.; Liang, H.; Ling, H.Q.
AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana
Cell Res.
18
566-576
2008
Arabidopsis thaliana (O82392), Arabidopsis thaliana
Manually annotated by BRENDA team
Dougherty, M.J.; Downs, D.M.
A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica
Microbiology
152
2345-2353
2006
Salmonella enterica subsp. enterica serovar Typhimurium (Q9L9I7)
Manually annotated by BRENDA team
Chatterjee, A.; Li, Y.; Zhang, Y.; Grove, T.L.; Lee, M.; Krebs, C.; Booker, S.J.; Begley, T.P.; Ealick, S.E.
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat. Chem. Biol.
4
758-765
2008
Caulobacter vibrioides (Q9A6Q5)
Manually annotated by BRENDA team
Lawhorn, B.G.; Mehl, R.A.; Begley, T.P.
Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction
Org. Biomol. Chem.
2
2538-2546
2004
Escherichia coli
Manually annotated by BRENDA team
Zhao, W.; Cheng, X.; Huang, Z.; Fan, H.; Wu, H., Ling, H.Q.
Tomato LeTHIC is an Fe-requiring HMP-P synthase involved in thiamine synthesis and regulated by multiple factors
Plant Cell Physiol.
52
967-982
2011
Solanum lycopersicum (B9TU32), Solanum lycopersicum
Manually annotated by BRENDA team
Raschke, M.; Bürkle, L.; Müller, N.; Nunes-Nesi, A.; Fernie, A.R.; Arigoni, D.; Amrhein, N.; Fitzpatrick, T.B.
Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC
Proc. Natl. Acad. Sci. USA
104
19637-19642
2007
Arabidopsis thaliana (O82392), Arabidopsis thaliana ecotype Col-0 (O82392)
Manually annotated by BRENDA team
Palmer, L.D.; Dougherty, M.J.; Downs, D.M.
Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica
J. Bacteriol.
194
6088-6095
2012
Salmonella enterica, Salmonella enterica DM851
Manually annotated by BRENDA team
Zhang, Q.; Liu, W.
Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes
J. Biol. Chem.
286
30245-30252
2011
Caulobacter vibrioides (Q9A6Q5), Salmonella enterica (Q9L9I7)
Manually annotated by BRENDA team
Palmer, L.D.; Downs, D.M.
The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites
J. Biol. Chem.
288
30693-30699
2013
Salmonella enterica
Manually annotated by BRENDA team
Coquille, S.; Roux, C.; Mehta, A.; Begley, T.P.; Fitzpatrick, T.B.; Thore, S.
High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana
J. Struct. Biol.
184
438-444
2013
Arabidopsis thaliana (O82392), Arabidopsis thaliana
Manually annotated by BRENDA team
Palmer, L.D.; Paxhia, M.D.; Downs, D.M.
Induction of the sugar-phosphate stress response allows Saccharomyces cerevisiae 2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase to function in Salmonella enterica
J. Bacteriol.
197
3554-3562
2015
Saccharomyces cerevisiae (P43534), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 / S288c (P43534)
Manually annotated by BRENDA team
Hwang, S.; Cordova, B.; Abdo, M.; Pfeiffer, F.; Maupin-Furlow, J.-A.
ThiN as a versatile domain of transcriptional repressors and catalytic enzymes of thiamine biosynthesis
J. Bacteriol.
199
pii: e00810-16
2017
Haloferax volcanii (D4GV87), Haloferax volcanii ATCC 29605 (D4GV87)
Manually annotated by BRENDA team
Ernst, D.C.; Borchert, A.J.; Downs, D.M.
Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways
PLoS ONE
13
e0197703
2018
Salmonella enterica subsp. enterica (Q9L9I7)
Manually annotated by BRENDA team