4.1.99.17: phosphomethylpyrimidine synthase

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For detailed information about phosphomethylpyrimidine synthase, go to the full flat file.

Reaction

Synonyms

2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.99 Other carbon-carbon lyases

                4.1.99.17 phosphomethylpyrimidine synthase

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Results	in table
2	Activating Compound
23880	AA Sequence
10	Cloned(Commentary)
12	Cofactor
2	Crystallization (Commentary)
12	Expression
35	General Information
8	Inhibitors
3	Ki Value [mM]
1	KM Value [mM]
8	Localization
13	Metals/Ions
5	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
21	Organism
1	Oxidation Stability
5	Pathway
8	PDB ID
2	pH Optimum
32	Protein Variants
4	Purification (Commentary)
5	Reaction
21	Reference
6	Source Tissue
35	Substrates and Products (Substrate)
6	Subunits
39	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.1.99.17 - phosphomethylpyrimidine synthase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

purified recombinant His-tagged DELTAN71-AtTHIC mutant, by a proteolysis assay (especially alpha-chymotrypsin) coupled with the sitting drop vapor diffusion technique at 18°C, using 0.01 M cobalt (II) chloride hexahydrate, 0.1 M sodium acetate trihydrate, pH 4.6, 1 M 1,6-hexanediol, X-ray diffraction structure determination and analysis at 1.6 A resolution

Arabidopsis thaliana

O82392

728216

selenomethionine HMP-P synthase/HMP crystals are grown using the sitting drop vapor diffusion method at 25°C. The crystals are monoclinic, space group P2(1), with unit cell dimension a = 63.3 A, b = 103.4 A, c = 95.4 A and beta = 91.6°

Caulobacter vibrioides

Q9A6Q5

716307