Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.99.17 extracted from

  • Zhao, W.; Cheng, X.; Huang, Z.; Fan, H.; Wu, H., Ling, H.Q.
    Tomato LeTHIC is an Fe-requiring HMP-P synthase involved in thiamine synthesis and regulated by multiple factors (2011), Plant Cell Physiol., 52, 967-982.
    View publication on PubMed
Search for more literature for 4.1.99.17

Cloned(Commentary)

Cloned (Comment) Organism
LeThiC under the control of the cauliflower mosaic virus 35S promoter is introduced into the tl mutant by Agrobacterium tumefaciens-mediated transformation. Expression of the wild-type LeThiC gene in the tl mutant is able to complement the mutant to wild type Solanum lycopersicum

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Solanum lycopersicum 9507
-

Metals/Ions

Metals/Ions Comment Organism Structure
iron-sulfur centre
-
 Solanum lycopersicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Solanum lycopersicum the enzyme is involved in thiamin biosynthesis 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum lycopersicum B9TU32
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Solanum lycopersicum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
-
 Solanum lycopersicum 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in thiamin biosynthesis Solanum lycopersicum 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Synonyms

Synonyms Comment Organism
LeThiC
-
 Solanum lycopersicum

Expression

Organism Comment Expression
Solanum lycopersicum expression of LeThiC is tightly regulated at the transcriptional and posttranscriptional level by multiple factors, such as light, Fe2+ status and thiamine diphosphate-riboswitch. A feedback regulation mechanism is involved in synthesis of the pyrimidine moiety for controlling thiamine synthesis in tomato additional information
Solanum lycopersicum the abundance of LeTHIC expression is dependent on light up
Solanum lycopersicum the expression intensity of LeThic at both the transcriptional (S form mRNA) and protein levels is increased under Fe2+ deficiency (1 or 0 mM Fe2+) compared with Fe2+ sufficiency (10 and 100 mM Fe2+), whereas no effects on LeThiC expression are observed under deficiency of Zn2+ or Mn2+ up

General Information

General Information Comment Organism
physiological function the enzyme is involved in thiamine biosynthesis Solanum lycopersicum