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Literature summary for 4.1.99.17 extracted from

  • Kong, D.; Zhu, Y.; Wu, H.; Cheng, X.; Liang, H.; Ling, H.Q.
    AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana (2008), Cell Res., 18, 566-576.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression of AtTHIC can functionally complement the thiC knock-out mutant of Escherichia coli Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
Arabidopsis thaliana 9507
-
plastid
-
Arabidopsis thaliana 9536
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Arabidopsis thaliana the enzyme is involved in the biosynthesis of thiamine diphosphate 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O82392
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower strong expression Arabidopsis thaliana
-
leaf strong expression Arabidopsis thaliana
-
silique strong expression Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine
-
Arabidopsis thaliana 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
?
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in the biosynthesis of thiamine diphosphate Arabidopsis thaliana 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
?

Synonyms

Synonyms Comment Organism
AtTHIC
-
Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana downregulation of AtTHIC expression by T-DNA insertion at its promoter region results in a drastic reduction of thiamine content in plants and the knock-down mutant thic1 shows albino (white leaves) and lethal phenotypes under the normal culture conditions down

General Information

General Information Comment Organism
malfunction downregulation of AtTHIC expression by T-DNA insertion at its promoter region results in a drastic reduction of thiamine content in plants and the knock-down mutant thic1 shows albino (white leaves) and lethal phenotypes under the normal culture conditions Arabidopsis thaliana
physiological function the enzyme is involved in the biosynthesis of thiamine diphosphate Arabidopsis thaliana