4.1.99.17: phosphomethylpyrimidine synthase

This is an abbreviated version!
For detailed information about phosphomethylpyrimidine synthase, go to the full flat file.

Reaction

Synonyms

2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.99 Other carbon-carbon lyases

                4.1.99.17 phosphomethylpyrimidine synthase

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Results	in table
2	Activating Compound
23880	AA Sequence
10	Cloned(Commentary)
12	Cofactor
2	Crystallization (Commentary)
12	Expression
35	General Information
8	Inhibitors
3	Ki Value [mM]
1	KM Value [mM]
8	Localization
13	Metals/Ions
5	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
21	Organism
1	Oxidation Stability
5	Pathway
8	PDB ID
2	pH Optimum
32	Protein Variants
4	Purification (Commentary)
5	Reaction
21	Reference
6	Source Tissue
35	Substrates and Products (Substrate)
6	Subunits
39	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Reaction

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Reaction on EC 4.1.99.17 - phosphomethylpyrimidine synthase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

5 entries

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

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5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

mechanistic analysis

Bacteria

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713759

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

radical reaction mechanism, overview

Caulobacter vibrioides

Q9A6Q5

727883

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

radical reaction mechanism, overview

Salmonella enterica

Q9L9I7

727883

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO

the enzyme uses a [4Fe-4S]
cluster to reductively cleave AdoMet to methionine and a 5'-deoxyadenosyl radical that initiates catalysis

Salmonella enterica

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727960