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4.1.99.17: phosphomethylpyrimidine synthase

This is an abbreviated version!
For detailed information about phosphomethylpyrimidine synthase, go to the full flat file.

Word Map on EC 4.1.99.17

Reaction

5-amino-1-(5-phospho-D-ribosyl)imidazole
+
S-adenosyl-L-methionine
=
4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
+
5'-deoxyadenosine
+
L-methionine
+
formate
+
CO

Synonyms

2-methyl-4-amino-5-hydroxymethylpyrimidine phosphate synthase, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase, AtTHIC, HMP phosphate synthase, HMP-P synthase, LeThiC, Thi5p, thiC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.17 phosphomethylpyrimidine synthase

Systematic Name

Systematic Name on EC 4.1.99.17 - phosphomethylpyrimidine synthase

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SYSTEMATIC NAME
IUBMB Comments
5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)
Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.